The frequency of side effects is classified according to the recommendations of the World Health Organization: very often - no less than 10%, often less than 1%, but less than 10%, infrequently - not less than 0.1%, but less than 1%, rarely - not less than 0.01%, but less than 0.1%, very rarely - less than 0.01%; The unknown frequency can not be estimated from the available data.
Infectious diseases: infrequently - candidiasis, including mucous membranes of the oral cavity and genitals, pneumonia, pharyngitis, gastroenteritis, respiratory diseases, rhinitis; an unknown frequency is pseudomembranous colitis.
From the side of the blood and lymphatic system: infrequently - leukopenia, neutropenia, eosinophilia; very rarely - thrombocytopenia, hemolytic anemia.
From the side of metabolism and nutrition: infrequently - anorexia.
Allergic reactions: infrequently angioedema, hypersensitivity reaction; an unknown frequency is an anaphylactic reaction.
From the nervous system: often - headache; infrequently - dizziness, dyspnoea, paresthesia, drowsiness, insomnia, nervousness; rarely - agitation; unknown frequency - hypesthesia, anxiety, aggression, fainting, convulsions, psychomotor hyperactivity, loss of smell, perversion of smell, loss of taste sensations, myasthenia gravis, delirium, hallucinations.
From the side of the organ of vision: infrequently - impaired vision.
From the side of the hearing organ and labyrinthine disorders: infrequently - hearing disorder, vertigo; unknown frequency - hearing impairment, including deafness and / or tinnitus.
From the cardiovascular system: infrequently - a feeling of palpitations, "tides" of blood to the face; unknown frequency - lowering blood pressure, increasing the interval QT on an electrocardiogram, arrhythmia such as "pirouette", ventricular tachycardia.
From the respiratory system: infrequently - shortness of breath, nosebleed.
From the side gastrointestinal tract: very often diarrhea; often - nausea, vomiting, abdominal pain; infrequent - meteorism, dyspepsia, constipation, gastritis, dysphagia, bloating, dryness of the oral mucosa, belching, ulcers of the oral mucosa, increased secretion of the salivary glands; very rarely - a discoloration of the tongue, pancreatitis.
From the liver and bile ducts: infrequently - hepatitis; rarely a violation of the liver, cholestatic jaundice; unknown frequency - hepatic insufficiency (in rare cases with a legal outcome mainly against a background of severe impairment of liver function); liver necrosis, fulminant hepatitis.
From the skin and subcutaneous tissues: infrequently - skin rash, itching, hives, dermatitis, dry skin, sweating; rarely - the reaction of photosensitization; unknown frequency - Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme.
From the musculoskeletal system: infrequently - osteoarthritis, myalgia, back pain, neck pain; unknown frequency - arthralgia.
From the side of the kidneys and urinary tract: infrequently - dysuria, pain in the kidney; unknown frequency - interstitial nephritis, acute renal failure.
From the genitals and breast: infrequently - metrorrhagia, dysfunction of testicles.
Other: infrequently - asthenia, malaise, fatigue, face swelling, chest pain, fever, peripheral edema.
Laboratory data: often a decrease in the number of lymphocytes,increasing the number of eosinophils, basophils increase amount, increasing the number of monocytes, increased neutrophil count, reduced bicarbonate concentration in the blood plasma; infrequently - increased activity aspartate aminotransferase, alanine aminotransferase, increasing the concentration of bilirubin in blood plasma, increasing concentrations of urea in the blood plasma, increased plasma concentrations of creatinine, the change of potassium content in the blood plasma, increased alkaline phosphatase activity in plasma, increasing chlorine content in the blood plasma, increased glucose concentration in blood, an increase in the number of platelets, increase of hematocrit, increase of bicarbonate concentration in blood plasma, change of sodium content in blood plasma.