The risk of side effects can be minimized if you take the drug with a short course, at the lowest effective dose needed to eliminate the symptoms.
Side effects are predominantly dose-dependent. The following adverse reactions were noted with a short-term intake of ibuprofen in doses not exceeding 1200 mg / day. In the treatment of chronic conditions and with prolonged use, other side reactions may occur.
To indicate the frequency of side effects, the following classification is used: Often (≥ 1/10), often (≥ 1/100 and <1/10), infrequently (≥ 1/1000 and <1/100), rarely (≥ 1/10000 and <1/1000), rarely (< 1/10000), frequency unknown (can not be estimated from available data).
From the side of the blood and lymphatic system: rarely: hematopoietic disorders (anemia, leukopenia, aplastic anemia, hemolytic anemia, thrombocytopenia, pancytopenia, agranutocytosis). The first symptoms of such disorders are fever, sore throat, superficial ulcers in the mouth, flu-like symptoms, severe weakness, nosebleeds and subcutaneous hemorrhages, bleeding and bruising of unknown etiology.
From the immune system: infrequently: hypersensitivity reactions - nonspecific allergic reactions and anaphylactic reactions,response from the respiratory tract (asthma, including its exacerbation, bronchoconstriction, dyspnea, dyspnea), skin reactions (pruritus, urticaria, purpura, angioedema, exfoliative and bullous dermatoses, including toxic epidermal necrolysis, Stevens-Johnson syndrome , erythema multiforme), allergic rhinitis, eosinophilia; rarely: Severe hypersensitivity reactions, including swelling of the face, tongue and throat, shortness of breath, tachycardia, hypotension (anaphylaxis, angioedema or severe anaphylactic shock).
From the gastrointestinal tract: infrequently: abdominal pain, nausea, dyspepsia; rarely: diarrhea, constipation, flatulence, vomiting; rarely: peptic ulcer, perforation or gastrointestinal bleeding, melena, bloody vomiting, ulcerative stomatitis, gastritis; frequency unknown: exacerbation of ulcerative colitis and Crohn's disease.
From the urinary and liver systems: rarely: acute renal failure, especially with prolonged use, in combination with increased levels of urea in plasma and the appearance of edemas, papillary necrosis, liver dysfunction, hepatitis.
From the nervous system: infrequently: headache; rarely: aseptic meningitis (in patients with autoimmune diseases).
From the cardiovascular system: frequency is unknown: cardiac insufficiency, peripheral edema, with prolonged use increased risk of thrombotic complications (eg, myocardial infarction, stroke), increased blood pressure.
From the respiratory system and mediastinal organs: frequency is unknown: A bronchial asthma, a bronchospasm, a dyspnea or short wind.
Other: rarely: edema, including peripheral.
Laboratory indicators: hematocrit or hemoglobin (may decrease), bleeding time (may increase), plasma glucose concentration (may decrease), creatinine clearance (may decrease), plasma creatinine concentration (may increase), activity of "hepatic" transaminases (may increase).
If these or other side effects occur, discontinue use and consult a doctor.