Nurofen Express - instructions for use, dose, side effects, contraindications

Composition:100 g of gel contains active substance: ibuprofen 5 g and Excipients: giethyl cellulose 1.8 g, sodium hydroxide QS (0.93 - 1 g), benzene alcohol 1 g, isopropanol 5 g, purified water 86.2 g.

Description:Transparent or slightly opalescent colorless homogeneous gel with a characteristic smell of isopropyl alcohol.

Pharmacotherapeutic group:Non-steroidal anti-inflammatory drug (NSAID).

ATX: & nbsp

M.01.A.E.01 Ibuprofen

Pharmacodynamics:

The drug belongs to non-steroidal anti-inflammatory drugs (NSAIDs). Has a double action: analgesic and anti-inflammatory. Ibuprofen, being a derivative of propionic acid, indiscriminately blocks COX-1 and COX-2, which inhibits the synthesis of prostaglandins - mediators of pain, inflammation and hyperthermia. When applied to the skin, the gel has an additional cooling effect due to rapid evaporation of the benzyl alcohol contained in the alcohol composition.

Pharmacokinetics:

After application on the skin ibuprofen is found in the epidermis and dermis after 24 hours. In deeper tissues, about 5% of ibuprofen is absorbed. Multiple application of the drug is sufficient to achieve a therapeutic concentration of ibuprofen in the underlying tissues, clinically significant systemic absorption hardly occurs.

Indications:As a local anesthetic and anti-inflammatory drug in such conditions as muscle pains, back pain, arthritis, ligament injuries, sprains, sports injuries and neuralgia.

Contraindications:

- Hypersensitivity to ibuprofen or other components of the drug, acetylsalicylic acid or other NSAIDs.

- Bronchial asthma, hives, rhinitis, triggered by the use of acetylsalicylic acid (salicylates) or other NSAIDs.

- Violations of the integrity of the skin at the site of application (including infected abrasions and wounds, dandruff, eczema).

- Children up to 14 years.

- Pregnancy III trimester.

Carefully:Before using the drug, you should consult with your doctor if you have concomitant liver or kidney disease, the gastrointestinal tract; with bronchial asthma, hives, rhinitis, polyps of the nasal mucosa; pregnant (I-II trimesters of pregnancy) and breast-feeding women.

Pregnancy and lactation:

The drug is contraindicated in the III trimester of pregnancy.

If possible, avoid using the drug in the I-II trimesters of pregnancy (ibuprofen may cause a delay in the timing of delivery and an increase in their duration).

There is evidence that ibuprofen in small quantities can penetrate into breast milk without any negative consequences for the health of the infant.

Dosing and Administration:

For external use only.

Nurofen® Express gel is prescribed for adults and children over 14 years of age. When using the tube for the first time: After opening the lid, check that the safety foil on the tube neck is not damaged. Open the foil by pressing it against the outside of the cover.

Squeeze 4 to 10 cm of the drug (equivalent to approximately 50 to 125 mg of ibuprofen) from the tube and gently rub the gel into the skin until it is completely absorbed.

Immediately after using the product, you should wash your hands.

Re-use the drug should not be earlier than 4 hours later. Do not do it

Apply the gel more than four times within 24 hours.

If the symptoms persist or worsen during the 2 weeks of the drug use, discontinue treatment and consult a doctor. Do not exceed the indicated dose.

Side effects:

Hypersensitivity reactions:

- nonspecific allergic reactions and anaphylactic reactions,

- reactions from the respiratory tract: bronchial asthma (including its aggravation), bronchospasm, shortness of breath, Quincke's edema,

- skin reactions at the site of application of the gel: urticaria, rash, skin flushing, sensation of burning or tingling, less often - exfoliative and bullous dermatoses (including toxic epidermal necrolysis and erythema multiforme).

Disorders from the gastrointestinal tract:

- abdominal pain, indigestion.

With prolonged use, it is possible to develop systemic side effects of NSAIDs.

If side effects occur, discontinue use and consult a doctor.

Overdose:

No cases of a gel overdose Nurofen® Express have been identified. If the drug is accidentally ingested, the following symptoms may occur: headache, vomiting, drowsiness, lowering blood pressure. In this situation, gastric lavage is recommended (only within an hour after taking), reception of activated charcoal, alkaline (drinking, forced diuresis, symptomatic therapy.

Interaction:

Drug Interactions ibuprofen gel with other drugs is not described.

It should be borne in mind that even with topical application of ibuprofen it is not possible to completely exclude its systemic effect and, theoretically, with simultaneous application ibuprofen Gel with other NSAIDs may increase side effects.

Special instructions:

Avoid contact with eyes, lips and other mucous membranes, inflamed or damaged skin.

Do not use in conjunction with an olyusluzionnoy (hermetic) medical dressing.

Avoid excessive exposure to sunlight on the area of application.

Patients with impaired renal function, with bronchial asthma before using the drug should consult with a doctor.

Effect on the ability to drive transp. cf. and fur:Patients who report dizziness, drowsiness, blockage, or visual impairment should avoid driving vehicles or controlling mechanisms when taking medications containing ibuprofen.

Form release / dosage:

Gel for external use 5%.

Packaging:For 30 g, 50 g, 60 g, 100 g, 120 g, 150 g, 180 g or 200 g of gel in an aluminum tube, covered from the inside with an epoxy-phenolic lacquer layer, with a polyethylene lid. One tube is placed in a cardboard box along with instructions for use.

Storage conditions:

At a temperature of no higher than 25 ° C.

Keep the drug out of the reach of children.

Shelf life:

3 years.

Do not use the drug with expired shelf life.

Terms of leave from pharmacies:Without recipe

Registration number:P N 015794/01

Date of registration:29.06.2009

The owner of the registration certificate:Rekitt Benckiser Helsar International Ltd.Rekitt Benckiser Helsar International Ltd. United Kingdom

Manufacturer: & nbsp

FARMASIERRA MANUFACTURING, S.L. Spain

Representation: & nbspREKITT BENKIZER HELSKER LTD. REKITT BENKIZER HELSKER LTD. United Kingdom

Information update date: & nbsp05.02.2014

Illustrated instructions

Instructions

Nurofen® Express (Nurofen® Express)