When used within 2-3 days, side effects are rare. In the case of prolonged use, the risk of side effects increases:
From the digestive system: NSAIDs-gastropathy (nausea, vomiting, abdominal pain, heartburn, decreased appetite, diarrhea, flatulence, pain and discomfort in the epigastric region), ulceration of the gastrointestinal mucosa (in some cases complicated by perforation and bleeding); irritation, dryness of the oral mucosa or pain in the mouth, ulceration of the gingival mucosa, aphthous stomatitis, pancreatitis, constipation, hepatitis.
From the respiratory system: shortness of breath, bronchospasm.
From the sense organs: hearing loss, ringing or noise in the ears, reversible toxic optic neuritis, blurred vision or diplopia, dryness and irritation of the eyes, conjunctival edema and eyelids (allergic genesis), scotoma.
From the nervous system: headache, dizziness, insomnia, anxiety, nervousness and irritability, psychomotor agitation, drowsiness, depressions, confusion, hallucinations, rarely - aseptic meningitis (more often in patients with autoimmune diseases).
From the cardiovascular system: development or aggravation of heart failure, tachycardia, increased blood pressure.
From the urinary system: acute renal failure, allergic nephritis, nephrotic syndrome (edema), polyuria, cystitis.
Allergic reactions: skin rash (usually erythematous urticaria), itchy skin, angioedema, anaphylactoid reactions, anaphylactic shock, bronchospasm, fever. multiforme exudative erythema (including Stevens-Johnson syndrome). toxic epidermal necrolysis (Lyell's syndrome), eosinophilia, allergic rhinitis.
From the hematopoiesis: anemia (including haemolytic, aplastic), thrombocytopenia and thrombocytopenic purpura, agranulocytosis, leukopenia.
Other: increased sweating.