The risk of side effects can be minimized if you take the drug with a short course, at the lowest effective dose needed to eliminate the symptoms.
Side effects are predominantly dose-dependent. The following adverse reactions were noted with a short-term intake of ibuprofen in doses not exceeding 1200 mg / day (3 capsules). In the treatment of chronic conditions and with prolonged use, other side reactions may occur.
The incidence of adverse reactions was estimated on the basis of the following criteria: very frequent (> 1/10), frequent (> 1/100 to <1/1 infrequent (> 1/1000 to <1/100), rare (> 1/10 000 to <1/1000), very rare (<1/10 000).
Violations of the blood and lymphatic system
- Very rare: hematopoietic disorders (anemia, leukopenia, aplastic anemia, hemolytic anemia, thrombocytopenia, pancytopenia, agranulocytosis).The first symptoms of such disorders are fever, sore throat, superficial ulcers in the mouth, flu-like syndrome, severe weakness, nosebleeds and subcutaneous hemorrhages, bleeding and bruising of unknown etiology.
Immune system disorders
- Infrequent: hypersensitivity reactions - nonspecific allergic reactions and anaphylactic reactions, respiratory tract reactions (bronchial asthma, including its aggravation, bronchospasm, dyspnea, dyspnea), skin reactions (itching, urticaria, Quincke's edema, exfoliative and bullous dermatoses, toxic epidermal necrolysis, erythema multiforme), allergic rhinitis, eosinophilia.
- Very rare: aseptic meningitis (in patients with autoimmune disorders: systemic lupus erythematosus, mixed connective tissue disease), severe hypersensitivity reactions.
Disorders from the gastrointestinal tract
- Infrequent: abdominal pain, nausea, dyspepsia (including heartburn, decreased appetite), gastritis, bloating.
- Rare: diarrhea, flatulence, constipation and vomiting.
- Very rare: peptic ulcer, perforation or gastrointestinal bleeding, melena, bloody vomiting, in some cases fatal, especially in elderly patients, ulcerative stomatitis, exacerbation of colitis and Crohn's disease.
Disorders from the urinary system and liver
- Rare: papillonecrosis, nephritic syndrome, especially with prolonged use, in combination with an increase in the concentration of urea in the blood plasma and the appearance of edema, hematuria and proteinuria.
- Very rare: violations of the liver (especially with prolonged treatment), hepatitis and jaundice, nephrotic syndrome, acute renal failure (compensated and decompensated), interstitial nephritis, cystitis.
Disturbances from the nervous system
- Infrequent: dizziness, headache.
- Very rare: aseptic meningitis, stroke.
Disorders from the psyche
- Very rare: insomnia, anxiety, nervousness and irritability, psychomotor agitation, drowsiness, depression, confusion, hallucinations.
Impaired sensory organs
- Hearing impairment: hearing loss,ringing or noise in the ears; visual impairment: toxic damage to the optic nerve, blurred vision and, double vision, scotoma, dry eye irritation, edema of the conjunctiva and in (allergic genesis).
Disorders from the cardiovascular system
- Very rare: heart failure, increased arterial pressure, tachycardia.
Disturbances from the respiratory system and mediastinal organs
- Very rare: bronchial asthma, bronchospasm, shortness of breath and wheeze.
Disturbances from the skin and subcutaneous tissues
- Infrequent: various types of skin rashes.
- Very rare: severe forms of skin reactions, including Stevens-Johnson syndrome, erythema multiforme and toxic epidermal necrolysis (Lyell's syndrome).
Other
- Very rare: edema, including peripheral.
Laboratory indicators
- hematocrit or hemoglobin (may decrease)
- bleeding time (may increase)
- the concentration of glucose in the blood plasma (may decrease)
- clearance of creatinine (may decrease)
- plasma creatinine concentration (may increase)
- activity of "liver" transaminases (may increase)
If side effects occur, stop taking the medication and consult a doctor.