Nurofen® Rapid Forte (Nurofen® Rapid Forte)

The risk of side effects can be minimized if you take the drug with a short course, at the lowest effective dose needed to eliminate the symptoms.

In elderly people, there is an increased incidence of adverse reactions when NSAIDs are used, especially gastrointestinal bleeding and perforations, in some cases fatal.

Side effects are predominantly dose-dependent. In particular, the risk of developing gastrointestinal bleeding depends on the range of doses and duration of treatment.

The following adverse reactions were noted with a short-term intake of ibuprofen in doses not exceeding 1200 mg / day (3 tablets). In the treatment of chronic conditions and with prolonged use, other side reactions may occur.

The incidence of adverse reactions was assessed on the basis of the following criteria: very frequent (> 1/10), frequent (> 1/100 to <1/10), infrequent (> 1/1000 to <1/100), rare from> 1/10 000 to <1/1000), very rare (<1/10 000), the frequency is unknown (there is no data on frequency estimation).

Violations of the blood and lymphatic system

Very rare: hematopoietic disorders (anemia, leukopenia, aplastic anemia, hemolytic anemia, thrombocytopenia, pancytopenia, agranulocytosis). The first symptoms of such disorders are fever, sore throat, superficial oral ulcers, flu-like symptoms, severe weakness, nosebleeds and bruising, bleeding, and bruising of unknown etiology.

Immune system disorders

Infrequent: hypersensitivity reactions - nonspecific allergic reactions and anaphylactic reactions, respiratory tract reactions (bronchial asthma, including its aggravation, bronchospasm, dyspnea, dyspnea), skin reactions (itching, urticaria, purpura, Quincke's edema, exfoliative and bullous dermatoses , including toxic epidermal necrolysis (Lyell's syndrome), Stevens-Johnson syndrome, erythema multiforme), allergic rhinitis, eosinophilia.

Very rare: severe hypersensitivity reactions, including swelling of the face, tongue and larynx, dyspnea, tachycardia, arterial hypotension (anaphylaxis, Quincke's edema or severe anaphylactic shock).

Disorders from the gastrointestinal tract

Infrequent: abdominal pain, nausea, dyspepsia (including heartburn, bloating).

Rare: diarrhea, flatulence, constipation, vomiting.

Very rare: peptic ulcer, perforation or gastrointestinal bleeding, melena, bloody vomiting, in some cases fatal, especially in elderly patients, ulcerative stomatitis, gastritis.

The frequency is unknown: exacerbation of colitis and Crohn's disease.

Disturbances from the liver and bile ducts

Very rare: violations of the liver, increased activity of "liver" transaminases, hepatitis and jaundice.

Disorders from the kidneys and urinary tract

Very rare: acute renal failure (compensated and decompensated) especially with prolonged use, in combination with an increase in the concentration of urea in the blood plasma and the appearance of edema, hematuria and proteinuria, nephritic syndrome, nephrotic syndrome, papillary necrosis, interstitial nephritis, cystitis.

Disturbances from the nervous system

Infrequent: headache.

Very rare: aseptic meningitis.

Disorders from the cardiovascular system

The frequency is unknown: heart failure, peripheral edema, with prolonged use increased risk of thrombotic complications (eg, myocardial infarction), increased blood pressure.

Disturbances from the respiratory system and mediastinal organs

The frequency is unknown: bronchial asthma, bronchospasm, dyspnea.

Laboratory indicators

- hematocrit or hemoglobin (may decrease);

- bleeding time (may increase);

- the concentration of glucose in the blood plasma (may decrease);

- clearance of creatinine (may decrease);

- plasma concentration of creatinine (may increase);