When ingestion of ibuprofen preparations, the following cases of adverse reactions are described (they are rare):
Gastrointestinal tract (GIT)
NSAID gastropathy (abdominal pain, nausea, vomiting, heartburn, dyspepsia, decreased appetite, diarrhea, flatulence, constipation, rarely - ulceration of the mucous membrane of the digestive tract, which in some cases are complicated by perforation and hemorrhage sometimes with fatal outcome (especially in the elderly ), exacerbation of chronic colitis and Crohn's disease); irritation or dryness of the oral mucosa, pain in the mouth, ulceration of the gingival mucosa, aphthous stomatitis, pancreatitis. Bloating, gastritis, hematemesis, melena.
Hepatobiliary system
Very rarely: a violation of liver function, hepatitis, jaundice and other liver diseases.
Respiratory system
Shortness of breath, bronchospasm, exacerbation of asthma, wheezing, stridor.
Sense organs
Hearing impairment: hearing loss, vertigo, ringing or tinnitus;
visual impairment: toxic damage to the optic nerve, blurred vision or double vision, scotoma, dryness and irritation of the eyes, edema of the conjunctiva and eyelids (allergic genesis).
Central and peripheral nervous system
Sometimes headache, dizziness, insomnia, anxiety, nervousness and irritability, psychomotor agitation, drowsiness, depression, confusion, hallucinations; disturbance of cerebral circulation.
The cardiovascular system
Heart failure, stenocardia, tachycardia, increased blood pressure, swelling.
The use of such drugs may be associated with a slight increase in the risk of developed acute cardiovascular disorders (myocardial infarction or stroke). The risk increases with high doses and a long time of taking the drug. Do not exceed the recommended dose (no more than 3 tablets per day) or duration of application (no more than 10 days).
In the presence of cardiovascular disease, a previous stroke or having risk factors (for example, high blood pressure, diabetes, high cholesterol,smoking) should discuss the drug with the doctor.
urinary system
Acute renal failure, papillary necrosis, especially with prolonged
application, accompanied by an increase in the level of urea in the serum and edema, peripheral edema, allergic nephritis, nephrotic syndrome, interstitial nephritis, polyuria, cystitis, hematuria, proteinuria.
Allergic reactions
Hypersensitivity reactions: skin rash (usually erythematous or urticaria), face swelling, rash, maculopapular rash, itchy skin; extremely rare: angioedema (Quincke), anaphylactoid reactions, anaphylactic shock, bronchospasm or dyspnea, bullous dermatitis, erythema multiforme exudative, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), allergic rhinitis.
Organs of hematopoiesis
Anemia (including hemolytic, aplastic), leukopenia, thrombocytopenia and thrombocytopenic purpura, pancytopenia; agranulocytosis, eosinophilia.
The first symptoms: fever, sore throat, superficial ulceration of the oral mucosa, influenza-like symptoms, severe fatigue, bleeding and bruising of unknown origin;
The immune system
In patients with autoimmune diseases (systemic lupus erythematosus, mixed connective tissue diseases) during the treatment with ibuprofen, symptoms of aseptic meningitis such as cramps spasm, headache, nausea, vomiting, fever, loss of orientation may occur.
Other violations:
Absence of effect when taking the drug
Laboratory indicators:
- time of bleeding (may increase)
- the concentration of glucose in the serum (may decrease)
- clearance of creatinine (may decrease)
- Hematocrit or hemoglobin (may decrease)
- serum creatinine concentration (may increase)
- activity of "liver" transaminases (may increase)