Dolgit - instructions for use, doses, side effects, contraindications

Excipients: isopropapol, dimethylhydroxymethyldioxolane (Salketal), poloxamer a;b; c = 101; 56; 101 (Poloxamer 407, Pluronic F 127), medium chain triglycerides (Miglyol 812), purified water, lavender oil, orange flower oil (neroli oil).

Description:

Transparent, colorless gel with a characteristic odor.

Pharmacotherapeutic group:NSAIDs

ATX: & nbsp

M.01.A.E.01 Ibuprofen

Pharmacodynamics:The drug has a local anesthetic and anti-inflammatory effect. Suppresses the production of inflammatory mediators. It does not selectively block cyclooxygenase (COX-1 and COX-2) and has an inhibitory effect on the synthesis of prostaglandin, prostacyclin and thromboxane.

Analgesic effect is most pronounced for inflammatory pains: the drug weakens the pain syndrome with pain at rest and during movement; reduces morning stiffness and swelling of the joints; promotes an increase in the volume of movements.

In addition to the anti-inflammatory effect, ibuprofen reduces aggregation of platelets at the site of inflammation, as well as migration of leukocytes and release of lysosomal enzymes in the inflammation zone.

Pharmacokinetics:

When applying the gel to the skin ibuprofen penetrates deeper tissues (subcutaneous fat, muscles, joints, synovial fluid) and reaches therapeutic concentrations in them.The therapeutic effect in the area of application is achieved by direct distribution through the skin in the target tissue. In an insignificant amount is determined in blood plasma. With the recommended method of application, the concentration in the synovial fluid is about 2 μg / ml.

Indications:

- Inflammatory and degenerative diseases of the support of the no-impellent system: articular syndrome with exacerbation of gout, arthritis (rheumatoid, psoriatic, gouty), humerous periarthritis, ankylosing spondylitis (Bechterew's disease), deforming osteoarthritis, osteochondrosis with radicular syndrome, sciatica, tendonitis, tendovaginitis, bursitis , lumbago, sciatica.

- Muscle pain (myalgia) of rheumatic and non-rheumatic origin.

- Injuries (sports, industrial, household, etc.) without compromising the integrity of the skin (dislocations, sprains or ruptures of muscles and ligaments, bruises, posttraumatic swelling of soft tissues, etc.).

Contraindications:

Hypersensitivity to ibuprofen, components of the drug and other NSAIDs; A bronchial asthma, a urticaria, a rhinitis caused by reception of an acetylsalicylic acid; wetting dermatoses, eczema, violations of the integrity of the skin in the place of application of the gel,including infected wounds and abrasions; pregnancy (III trimester), children under 12 years.

Carefully:

Pregnancy (I-II term), the period of lactation.

Dosing and Administration:

OUTSIDE! A strip of gel 5-10 cm long is applied to the area of injury and carefully rubbed with light movements until completely absorbed 3-4 times a day. The duration of treatment depends on the severity of the disease and the nature of the damage, and is, on average, 2-3 weeks.

Side effects:

Usually the drug is well tolerated. In rare cases, temporary signs of local irritation of the skin in the form of redness, swelling, rashes, itching of the skin, a burning sensation and tingling may occur. In the case of hypersensitivity to NSAIDs, the phenomena of bronchospasm are possible. Prolonged use of the drug in particularly sensitive patients can lead to the development of systemic side effects, when the appearance of which should stop taking the drug and see a doctor.

Overdose:

Cases of drug overdose are not described.

If you randomly take the drug inside, you need to stimulate vomiting, flushing the stomach, take Activated carbon. Further treatment, if necessary, symptomatic.

Interaction:

Drug interaction with other drugs is not described.

However, it should be borne in mind that even with topical application ibuprofen has a systemic effect, and, theoretically, with the simultaneous use of the gel with other NSAIDs, side effects can be exacerbated.

Special instructions:

In severe cases, combined use of the gel is recommended externally with the administration of other NSAID dosage forms (parenterally, orally, rectally).

Avoid contact with eyes and mucous membranes.

Effect on the ability to drive transp. cf. and fur:

The use of the drug does not affect the activity requiring increased attention, coordination of movements, high speed of mental and physical reactions (for example, in transport drivers, persons working with complex mechanisms, etc.).

Form release / dosage:Gel for external use, 5%.

Packaging:

By 20 g, 50 g or 100 g of gel in an aluminum tube with an inner protective lacquer coating, sealed with a membrane and a screwed plastic cap.

One tube with the instruction for use is placed in a cardboard box.

Storage conditions:

Store in a dry place, at a temperature of 15-25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

He apply after expiry date.

Terms of leave from pharmacies:Without recipe

Registration number:П N015270 / 01

Date of registration:24.11.2008 / 05.02.2010

Expiration Date:Unlimited

The owner of the registration certificate:Dolorgit GmbH & Co. KGDolorgit GmbH & Co. KG Germany

Manufacturer: & nbsp

DOLORGIET, GmbH & Co. KG. KG Germany

Representation: & nbspDr. Thais Naturvaren Rus, Open CompanyDr. Thais Naturvaren Rus, Open Company

Information update date: & nbsp21.11.2016

Illustrated instructions

Instructions

Dolgit® (Dolgit®)