The risk of side effects can be minimized if you take the drug with a short course, at the lowest effective dose needed to eliminate the symptoms.
Side effects are predominantly dose-dependent.
The following adverse reactions were noted with a short-term intake of ibuprofen in doses not exceeding 1200 mg / day. In the treatment of chronic conditions and with prolonged use, other side reactions may occur.
According to the WHO, adverse reactions are classified according to their frequency of development as follows: very frequent (≥1 / 10), often (from ≥1 / 100 to <1/10), infrequent (from ≥1 / 1000 to <1/100 ), rare (from ≥1 / 10,000 to <1/1000), very rare (<1/10 000); frequency is unknown - according to available data, it was not possible to establish the frequency of occurrence.
From the side of the blood and lymphatic system:
- very rare: disturbances of hematopoiesis (anemia, leukopenia, aplastic anemia, hemolytic anemia, thrombocytopenia, pancytopenia, agranulocytosis). The first symptoms of such disorders are fever, sore throat, superficial oral ulcers, flu-like symptoms, severe weakness, nosebleeds and bruising, bleeding, and bruising of unknown etiology.
From the immune system:
- infrequent hypersensitivity reactions - nonspecific allergic reactions and anaphylactic reactions,reactions from the respiratory tract (bronchial asthma, including its aggravation, bronchospasm, dyspnea, dyspnea), skin reactions (itching, urticaria, purpura, Quincke's edema, exfoliative and bullous dermatoses, including toxic epidermal necrolysis (Lyell's syndrome), Stevens-Johnson syndrome, erythema multiforme), eosinophilia.
- very rare: severe hypersensitivity reactions, including swelling of the face, tongue and larynx, dyspnea, tachycardia, hypotension (anaphylaxis, Quincke's edema or severe anaphylactic shock).
From the gastrointestinal tract:
- infrequent: abdominal pain, nausea, indigestion.
- rare: diarrhea, flatulence, constipation, vomiting.
- very rare: peptic ulcer, perforation or gastrointestinal bleeding, melena, bloody vomiting, ulcerative stomatitis, gastritis.
- frequency unknown: exacerbation of ulcerative colitis and Crohn's disease.
From the liver and bile ducts:
- very rare: violations of the liver.
From the side of the kidneys and urinary tract:
- very rare: acute renal failure (compensated and uncompensated), especially with prolonged use, in combination with an increase in the concentration of urea in the blood plasma and the appearance of edema, papillary necrosis.
From the nervous system:
- infrequent: headache.
- very rare: aseptic meningitis (in patients with autoimmune diseases).
From the cardiovascular system:
- frequency unknown: heart failure, peripheral edema, with prolonged use increased risk of thrombotic complications (eg, myocardial infarction, stroke), increased blood pressure.
From the respiratory system and mediastinal organs:
- frequency unknown: bronchial asthma, bronchospasm, dyspnea.
Other:
- very rare: edema, including peripheral.
Laboratory indicators:
- hematocrit or hemoglobin (may decrease);
- bleeding time (may increase);
- the concentration of glucose in the blood plasma (may decrease);
- clearance of creatinine (may decrease);
- plasma concentration of creatinine (may increase);
- activity of "liver" transaminases (may increase).
If these or other side effects occur, discontinue use and consult a doctor.