According to the World Health Organization (WHO), unwanted effects are classified according to their frequency of development as follows: very often (> 1/10), often (> 1/100, <1/10), infrequently (> 1/1000, < 1/10000, rarely (> 1/10000, <1/1000), very rarely (<1/10000), the frequency is unknown (the frequency can not be determined based on the available data).
From the cardiovascular system:
rarely: tachycardia, heart failure, myocardial infarction, arterial hypertension.
From the side of the blood and lymphatic system:
rarely: violation of hematopoiesis (anemia, leukopenia, thrombocytopenia, pancytopenia, agranulocytosis).
From the nervous system:
infrequently: headache, dizziness, insomnia, agitation, irritability or fatigue.
From the side of the organ of vision: infrequently: impaired vision.
From the organ of hearing: rarely: noise in ears.
From the gastrointestinal tract:
often: heartburn, abdominal pain, nausea, vomiting, flatulence, diarrhea, constipation, minor gastrointestinal bleeding, which in exceptional cases can lead to the development of anemia;
infrequently: peptic ulcer with possible complications (bleeding, perforation), ulcerative stomatitis, exacerbation of colitis and Crohn's disease, gastritis;
rarely: esophagitis, pancreatitis, the development of intestinal membrane strictures.
From the liver and bile ducts:
rarely: impaired liver function, hepatotoxicity, especially with long-term treatment, liver failure, acute hepatitis.
From the side of the kidneys and urinary tract:
rarely: the development of edema, especially in patients with hypertension or renal insufficiency, nephrotic syndrome,interstitial nephritis, which can be accompanied by acute renal failure, damage to the renal tissue (papillary necrosis), and an increase in the level of uric acid in the blood.
From the skin and subcutaneous tissues:
rarely: Bullous eruptions, such as Stevens-Johnson syndrome and toxic epidermal necrolysis (Lyell's syndrome), alopecia.
Infectious and parasitic diseases:
rarely: aggravation of inflammation due to infection (for example, the development of necrotizing fasciitis); symptomatic of aseptic meningitis with stiff neck, headache, nausea, vomiting, fever or confusion, especially in patients with autoimmune diseases (SLE, mixed connective tissue diseases).
From the immune system:
infrequently: hypersensitivity reactions accompanied by urticaria and itching, as well as asthmatic attacks (possibly with a drop in blood pressure);
rarely: severe general hypersensitivity reactions, manifested in the form of facial swelling, swelling of the tongue, internal swelling of the larynx, accompanied by difficulty breathing, dyspnea,tachycardia, a drop in blood pressure until the development of a shock that poses a threat to life.
Disorders of the psyche:
rarely: psychotic reactions, depression.
If side effects occur, stop taking the medication and consult a doctor.