Qualification incidence of side effects produced on the basis of the following criteria: very frequent (> 1/10 destinations), frequent (from 1/10 to 1/100 destinations), infrequent (from 1/100 to 1/1000 destinations), rare (from 1/1000 to 1/10 000 appointments), very rare (<1/10 000 appointments).
When ingestion of ibuprofen preparations, the following cases of side effects are described:
- Disorders from the gastrointestinal tract
NSAID-gastropathy (infrequent: abdominal pain, nausea, heartburn, dyspepsia, anorexia, rare diarrhea, bloating, constipation, vomiting, very rare: ulceration of the gastrointestinal mucosa, which in some cases are complicated by perforation and hemorrhage sometimes with fatal outcome ( especially in the elderly), exacerbation of chronic colitis and Crohn's disease), very rare: irritation or dryness of mucous membranes of the mouth, pain in the mouth, ulceration of the mucous membrane of the gums, aphthous stomatitis, pancreatitis, abdominal distention , gastritis, vomiting with blood, melena.
- Disturbances from the liver and bile ducts
Very rare: a violation of liver function, hepatitis, jaundice and other liver diseases.
- Disturbances from the respiratory system. organs of the chest and mediastinum
Very rare: shortness of breath, bronchospasm, exacerbation of bronchial asthma, wheezing, stridor.
- Hearing disorders and labyrinthine disorders
Very rare: hearing loss, vertigo, ringing or noise in the ears.
- Disturbances on the part of the organ of sight
Very rare: visual disturbances: toxic damage to the optic nerve, blurred vision or double vision, scotoma, dryness and irritation of the eyes, edema of the conjunctiva and eyelids (allergic genesis).
- Disturbances from the nervous system
Infrequent: headache, dizziness, impaired cerebral circulation.
- Disorders of the psyche
Very rare: insomnia, anxiety, nervousness and irritability, psychomotor agitation, drowsiness, depression, confusion, hallucinations.
- Heart Disease
Very rare: heart failure, angina, tachycardia. Vascular disorders
Very rare: increased blood pressure, swelling.
- Disorders from the kidneys and urinary tract
Very rare: acute renal failure, papillary necrosis of the kidneys, especially with prolonged use,accompanied by increased urea concentration in the serum and edema, peripheral edema, allergic nephritis, nephrotic syndrome, interstitial nephritis, polyuria, cystitis, hematuria, proteinuria.
- Immune system disorders
Infrequent: hypersensitivity reactions: skin rash (usually erythematous or urticaria), face swelling, rash, maculopapular rash, itchy skin;
very rare: angioedema (Quincke), anaphylactoid reactions, anaphylactic shock, bronchospasm or dyspnea, bullous dermatitis, erythema multiforme exudative, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), allergic rhinitis.
Very rare: in patients with autoimmune diseases (systemic lupus erythematosus, mixed connective tissue disease) during treatment with ibuprofen may cause symptoms of aseptic meningitis, such as spasm of the neck muscles, headache, nausea, vomiting, fever, loss of orientation.
- Violations of the blood and lymphatic system
Very rare: anemia (including hemolytic, aplastic), leukopenia, thrombocytopenia and thrombocytopenic purpura,pancytopenia, agranulocytosis, eosinophilia.
- Other violations:
Absence of effect when taking the drug
- Laboratory and instrumental data:
- bleeding time (may increase)
- serum glucose concentration (may decrease)
- clearance of creatinine (may decrease)
- hematocrit or hemoglobin (may decrease)
- serum creatinine concentration (may increase)
- activity of "liver" transaminases (may increase)