In each frequency group, undesirable drug reactions are listed in order of decreasing significance. Estimated incidence of adverse reactions is based on the following criteria: very frequent (≥ 1/10), frequent (≥ 1/100 to <1/10), infrequent (from ≥ 1/1000 to <1/100), rare from ≥ 1/10 000 to <1/1000), very rare (<1/10 000), the frequency is unknown (according to available data, it was not possible to establish the frequency of occurrence).
When using ibuprofen for 2-3 days, side effects are very rare.In the case of prolonged use, the following side effects may occur:
From the gastrointestinal tract:
Infrequent: NSAIDs-gastropathy (abdominal pain, nausea, heartburn, loss of appetite),
rare: vomiting, diarrhea, flatulence, constipation,
very rare: ulceration of the mucosa (on the part of the gastrointestinal tract), which in some cases is complicated by perforation and bleeding); irritation or dryness of the oral mucosa, pain in the mouth, ulceration of the gingival mucosa, aphthous stomatitis, pancreatitis.
From the respiratory system, chest and mediastinum:
Very rare: shortness of breath, bronchospasm.
From the sense organs:
Very rare: hearing impairment: hearing loss, "ringing or tinnitus"; visual impairment: toxic damage to the optic nerve, blurred vision or double vision, scotoma, dryness and irritation of the eyes, edema of the conjunctiva and eyelids (allergic genesis).
From the central and peripheral nervous system:
Infrequent: headache, dizziness,
very rare: insomnia, anxiety, nervousness and irritability, psychomotor agitation, drowsiness, depression, confusion, hallucinations, rarely aseptic meningitis (more often in patients with autoimmune diseases).
From the cardiovascular system:
Very rare: heart failure, tachycardia, increased blood pressure.
From the liver and bile ducts:
Very rarely: hepatitis.
From the side of the kidneys and urinary tract:
Rare: acute renal failure, allergic nephritis, nephrotic syndrome (edema), polyuria, cystitis.
From the skin and subcutaneous tissues:
Infrequent: skin rash (usually erythematous or urticaria), itchy skin,
very rare: angioedema, anaphylactoid reactions, anaphylactic shock, bronchoconstriction or dyspnea, fever, erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), eosinophilia, allergic rhinitis.
From the side of the blood and lymphatic system:
Rare: anemia (including haemolytic, aplastic), thrombocytopenia and trombotsitoienicheskaya purpura, agranulocytosis, leukopenia.
Laboratory and instrumental data:
- Bleeding time (may increase),
- concentration of glucose in the serum (may decrease),
- clearance of creatinine (may decrease),
-hematocrit or hemoglobin (may decrease),
- serum creatinine concentration (may increase),
- activity of "liver transaminases" (may increase).
If side effects occur, stop taking the medication and consult a doctor.