Calcium gluconate - instructions for use, dose, side effects, contraindications

The preparation of calcium replenishes the deficiency of calcium ions necessary for the process of transmission of nerve impulses, reduction of skeletal and smooth muscles, myocardial activity, the formation of bone tissue, and the coagulation of blood.

Pharmacokinetics:

Approximately 1 / 5-1 / 3 part of the orally administered drug is absorbed into the small intestine; this process depends on the presence of the vitamin D, pH, features of the diet and the presence of factors that can bind calcium ions. The absorption of calcium ions increases with its deficiency and the use of a diet with a reduced content of calcium. About 20% is excreted by the kidneys, the rest (80%) is the intestine.

Indications:

Diseases accompanied by hypocalcemia, increased permeability of cell membranes (including blood vessels), impaired conduction of nerve impulses in muscle tissue.

Hypoparathyroidism (latent tetany, osteoporosis), metabolic disturbances of the vitamin D: rickets (spasmophilia, osteomalacia), hyperphosphataemia in patients with chronic renal insufficiency.

The increased need for calcium ions (pregnancy, lactation period, the period of increased body growth), insufficient calcium ions in the diet, a violation of its metabolism (in the postmenopausal period).

Enhanced excretion of calcium ions (prolonged bed rest, chronic diarrhea, secondary hypocalcemia, long-term use of diuretics and antiepileptic drugs, glucocorticosteroids).

Poisoning with magnesium salts, oxalic and hydrofluoric acids and their soluble salts (in the interaction with calcium gluconate insoluble and non-toxic calcium oxalate and calcium fluoride are formed).

Hyperkaliemic form of paroxysmal myoplegia.

Contraindications:

Hypersensitivity, hypercalcemia (concentration of calcium ions should not exceed 12 mg% = 6 mEq / L), expressed hypercalciuria, nephrourolythiasis (calcium), sarcoidosis, simultaneous reception of cardiac glycosides (risk of arrhythmias), children under 3 years.

Carefully:

Dehydration, electrolyte disorders (risk of hypercalcemia), diarrhea, malabsorption syndrome, calcium nephrourolythiasis (in the anamnesis), minor hypercalciuria, moderate chronic renal failure, chronic heart failure, prevalent atherosclerosis, hypercoagulation.

Dosing and Administration:

Inside, before meals or 1-1.5 hours after intake (squeezed milk).

Adults -1-3 g 2-3 times a day.

Children 3-4 years - 1 g; 5-6 years - 1-1.5 g; 7-9 years - 1.5-2 g; 10-14 years - 2-3 g; the frequency of reception is 2-3 times a day.

Side effects:Constipation, irritation of the mucous membrane of the gastrointestinal tract, hypercalcemia.

Overdose:

Symptoms: hypercalcemia.

Treatment: parenterally - 5-10 IU / kg / day of calcitonin (diluting it in 500 ml of 0.9% sodium chloride solution). Duration of administration 6 hours.

Interaction:

Forms insoluble complexes with antibiotics of the tetracycline series (reduces the antibacterial effect).

Reduces the effect of blockers of "slow" calcium channels.

With simultaneous application with quinidine, it is possible to slow intraventricular conduction and increase the toxicity of quinidine.

Slows the absorption of tetracyclines, digoxin, oral iron preparations (the interval between their methods should be at least 2 hours).

When combined with thiazide diuretics can increase hypercalcemia. Reduces the effect of calcitonin in hypercalcemia.

Reduces the bioavailability of phenytoin.

Special instructions:

In patients with minor hypercalciuria, a decrease in glomerular filtration or with nephrourolythiasis in history, treatment should be controlled by the concentration of calcium ions in the urine.

Drinking plenty is recommended to reduce the risk of nephrourolythiasis.

Form release / dosage:Tablets 500 mg.

Packaging:

10 tablets in a contour non-cellular package made of paper with polyethylene coating.

10 tablets in a contour mesh box made of polyvinylchloride film and aluminum foil or paper with polyethylene coating.

100 contour packs with the application of an equal number of instructions for use are placed in a group package-a box of cardboard.

10 tablets into a can of orange glass of the BTS type, sealed with a plastic pull-on lid with a sealing element or into a polymer-type cans of BP. Each bank with instructions for use is placed in a pack of cardboard.

Storage conditions:

In a dry place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

5 years.

Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LS-002729

Date of registration:01.06.2011

Expiration Date:Unlimited

The owner of the registration certificate:BIOSINTEZ, PAO BIOSINTEZ, PAO Russia

Manufacturer: & nbsp

BIOSINTEZ, PAO Russia

Information update date: & nbsp23.11.2017

Illustrated instructions

Instructions

Calcium gluconate (Calcium gluconate)