Calcium gluconate-lekT - instructions for use, dose, side effects, contraindications

The preparation of calcium replenishes the calcium deficiency necessary for the process of transmission of nerve impulses, the reduction of skeletal and smooth muscles, myocardial activity, the formation of bone tissue, and the coagulation of blood.

Pharmacokinetics:

Approximately 1/5 - 1/3 part of the orally administered drug absorbed in the small intestine; this process depends on the presence of the vitamin D, pH, dietary characteristics and the presence of factors capable of binding calcium. The absorption of calcium increases with its deficiency and the use of a diet with a reduced content of calcium. About 20 % is excreted by the kidneys, the rest (80%) by the intestine.

Indications:

Diseases accompanied by hypocalcemia, increased permeability of cell membranes (including blood vessels), impaired conduction of nerve impulses in muscle tissue.

Hypoparathyroidism (latent tetany, osteoporosis), metabolic disturbances of the vitamin D: rickets (spasmophilia, osteomalacia), hyperphosphataemia in patients with chronic renal insufficiency.

The increased need for calcium (pregnancy, lactation, the period of intensive growth of the organism), the lack of calcium in the diet, the violation of its exchange (post-menopausal).

Enhanced excretion of calcium (prolonged bed rest, chronic diarrhea, secondary hypocalcemia, long-term use of diuretics and antiepileptic drugs, glucocorticosteroids).Poisoning with magnesium salts, oxalic and fluoric acids and their soluble salts (in the interaction with calcium gluconate insoluble and non-toxic calcium oxalate and calcium fluoride are formed).

Hyperkaliemic form of paroxysmal myoplegia.

Contraindications:Hypersensitivity, hypercalcemia (calcium concentration should not exceed 2.6 mmol / l), expressed hypercalciuria, nephrourolythiasis (calcium), sarcoidosis, simultaneous reception of cardiac glycosides (risk of arrhythmias), I trimester of pregnancy, children under 3 years.

Carefully:

Dehydration, electrolyte disorders (risk of hypercalcemia), diarrhea, malabsorption syndrome, calcium nephrourolythiasis (in the anamnesis), minor hypercalciuria, moderate chronic renal failure insufficiency (CRF), chronic heart failure (CHF), prevalent atherosclerosis, hypercoagulation.

Pregnancy and lactation:

During the first trimester of pregnancy, the use of the drug is not recommended, since the action of the drug may increase toxicosis.

The increase in the need for calcium begins with the second trimester of pregnancy,so prescribe the drug best after 14 weeks of pregnancy.

Application drug during breastfeeding is not contraindicated, but if necessary, consult your doctor!

Dosing and Administration:

Is taken orally before meals or 1-1,5 hours after eating (squeezed milk).

Adults - 1-3 g 2-3 times a day (the maximum daily dose - 9 g). Pregnant and lactating mothers - the maximum single dose - 0.5 g. A strict scheme of taking the drug is prescribed by the doctor especially individually. Children: 3-4 years - 1 g (maximum daily dose - 3.0 g); 5-6 years - 1-1,5 g (maximum daily dose - 4,5 g); 7-9 years - 1.5-2 g (the maximum daily dose - 6 g); 10-14 years - 2-3 g (the maximum daily dose - 9 g); the frequency of reception is 2-3 times a day.

When osteoporosis (hereditary disease), as well as with increased physical and emotional stress - 1 -3 g 2-3 times a day.

Prolonged bed rest - 0.5 g 2-3 times a day.

With intensive growth, ossification, increased bleeding, neuroses, allergic reactions, tuberculosis - 0.5 g 2-3 times a day.

The course of taking and the dose of the drug depends on the patient's condition and is recommended by the doctor in charge!

Side effects:

Constipation, irritation of the mucous membrane of the gastrointestinal tract, hypercalcemia, allergic reactions.

Overdose:

Symptoms: hypercalcemia often asymptomatic, its is detected by a blood test. The early symptoms of hypercalcemia are constipation, loss of appetite, nausea, vomiting and abdominal pain, and sometimes dehydration symptoms develop. Very severe hypercalcemia often causes symptoms of impaired brain function: confusion, emotional disorders, delirium, hallucinations, weakness and coma.

Treatment: The method of treatment depends on how high the concentration of calcium, and the reasons that caused it.

At low concentrations of calcium in the blood, it is sufficient to eliminate the underlying cause. People with normal kidney function are usually advised to drink more fluids.

At high concentrations of calcium (above 3.7 mmol / l), injected parenterally - 5-10 IU / kg / day. calcitonin (diluting it in 500 ml of 0.9% sodium chloride solution). Duration of administration is 6 hours.

The basis of treatment are diuretics, which increase the excretion of calcium by the kidneys. A highly effective and safe treatment is dialysis,but it is usually used for severe hypercalcemia, when other methods do not work.

Interaction:

Pharmaceutically incompatible with carbonates, salicylates, sulfates (forms insoluble or hardly soluble calcium salts).

Forms insoluble complexes with antibiotics of the tetracycline series (reduces the antibacterial effect).

Reduces the effect of blockers of "slow" calcium channels.

With simultaneous application with quinidine, it is possible to slow intraventricular conduction and increase the toxicity of quinidine. Slows the absorption of tetracyclines, digoxin, oral iron preparations (the interval between their methods should be at least 2 hours).

When combined with thiazide diuretics can increase hypercalcemia. Reduces the effect of calcitonin in hypercalcemia. Reduces the bioavailability of phenytoin.

Special instructions:

In patients with minor hypercalciuria, reduced glomerular filtration or with nephrourolythiasis in history, treatment should be controlled by the concentration of calcium in the urine.

Drinking plenty is recommended to reduce the risk of nephrourolythiasis.

Effect on the ability to drive transp. cf. and fur:

The use of the drug does not affect the ability to drive vehicles and engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Form release / dosage:Tablets 500 mg.

Packaging:

For 10 tablets in a contour mesh box made of polyvinylchloride film and aluminum foil printed lacquered.

For 10 tablets in a contour non-cellular package of paper with a polymer coating.

On 2 contour mesh and non-jawed packages together with the instruction for use are placed in a pack of cardboard.

Contoured packages with an equal number of instructions for use are placed in a box of corrugated cardboard.

Storage conditions:

In a dry place, at a temperature of 15 to 25 ° C.

Keep out of the reach of children.

Shelf life:

5 years.

Do not use after expiry date.

Terms of leave from pharmacies:Without recipe

Registration number:LP-001622

Date of registration:03.04.2012

Expiration Date:Unlimited

The owner of the registration certificate:Tyumen Chemical - Pharmaceutical Plant, OJSC Tyumen Chemical - Pharmaceutical Plant, OJSC Russia

Manufacturer: & nbsp

Tyumen Chemical - Pharmaceutical Plant, OJSC Russia

Information update date: & nbsp23.11.2017

Illustrated instructions

Instructions

Calcium gluconate-lekT (Calcium gluconate-LekT)