Calcium gluconate - instructions for use, dose, side effects, contraindications

Pharmacodynamics:The preparation of calcium replenishes the calcium deficiency necessary for the process of transmission of nerve impulses, the reduction of skeletal and smooth muscles, myocardial activity, the formation of bone tissue, and the coagulation of blood.

Pharmacokinetics:

Approximately 1/5 - 1/3 part of the orally administered drug is absorbed in the small intestine; this process depends on the presence of the vitamin D, pH, features of the diet and the presence of factors that can bind calcium ions.

The absorption of calcium ions increases with its deficiency and the use of a diet with a reduced content of calcium.

About 20% is excreted by the kidneys, the rest (80%) is removed from the the contents of the intestine (actively allocated by the wall of the terminal section of the gastrointestinal tract).

Indications:

Hypofunction of the parathyroid glands (latent tetany, osteoporosis), metabolic disturbances of the vitamin D: rickets (spasmophilia, osteomalacia), hyperphosphatemia in patients with chronic renal insufficiency.

Conditions accompanied by an increased need for calcium (pregnancy, unbalanced and malnutrition).

Enhanced elimination of calcium ions (chronic diarrhea, secondary hypocalcemia on the background of long-term use of diuretics and antiepileptic drugs, glucocorticosteroid drugs).

Chronic intoxication with magnesium salts, oxalic and fluoric acids and their soluble salts (in interaction with calciumgluconate forms insoluble salts and non-toxic calcium oxalate and calcium fluoride).

Parenchymal hepatitis, toxic liver damage, nephritis, hyperkalemic form of paroxysmal myoplegia.

Contraindications:

Hypersensitivity to the components of the drug, hypercalcemia (calcium concentration should not exceed 12 mg% or 6 mEq / L), hypercalciuria, nephrolithiasis (calcium), sarcoidosis, cardiac glycoside intoxication (risk of arrhythmias), severe kidney failure, children under 5 years .

Carefully:

Dehydration, electrolyte disorders (risk of hypercalcemia), diarrhea, malabsorption syndrome, minor hypercalciuria, mild chronic renal failure, chronic heart failure, prevalent atherosclerosis, hypercoagulability, chronic gastrointestinal tract diseases, calcium nephrourolythiasis in anamnesis.

Pregnancy and lactation:

Use during pregnancy and breastfeeding as directed by a doctor.

Dosing and Administration:

Inside, before taking or 1-1.5 hours after eating (squeezed milk). Adults 2-6 tablets (1 -3 g) 2-3 times a day.

Children from 5 to 6 years - 2-3 tablets (1-1.5 g), from 7 to 9 years - 3-4 tablets (1.5-2 g), from 10 to 14 years - for 4- 6 tablets (2-3 g). Take 2-3 times a day.

Side effects:

Allergic reactions, constipation, irritation of the mucous membrane of the gastrointestinal tract, nausea, vomiting, diarrhea, pain in the upper abdomen.

Overdose:

Symptoms: hypercalcemia.

Treatment: to eliminate it, 5-10 IU / kg / day of calcitonin is administered (diluting it in 0.5 L of 0.9% sodium chloride solution). Duration of administration is 6 hours.

Interaction:

With simultaneous application with quinidine, it is possible to slow intraventricular conduction and increase the toxicity of quinidine.

Slows down the absorption of tetracyclines, digoxin, oral iron preparations (the interval between their administrations should be at least 2 h), when combined with thiazide diuretics can enhance hypercalcemia, reduce the effect of calcitonin in hypercalcemia, and reduce the bioavailability of phenytoin.

Pharmaceutically incompatible with ethanol, carbonates, salicylates. sulfates (forms insoluble or hardly soluble calcium salts).

Special instructions:

Patients with minor hypercalciuria,with minor impairment of kidney function or with a history of urolithiasis, the drug should be administered with caution and regularly monitor the level of excretion of calcium in the urine.

Patients with a tendency to form concrements in the urine are encouraged to increase the amount of fluid consumed.

Form release / dosage:

Tablets 500 mg.

Packaging:

For 10 tablets in a contour mesh box made of polyvinylchloride film and aluminum foil printed lacquered.

For 10 tablets in a contour non-jawed packaging made of material combined on paper and cardboard basis with polyethylene coating, or combined material "Buflen".

By 1, 2, 4, 6, 10 contour mesh or contour non-jawed packages together with the instruction for use are placed in a pack of consumer paperboard or a hermetically sealed plastic bag made of light-proof polyethylene film or a bag of material combined on paper and cardboard basis with polyethylene coating, or the material of the combined "Bufleen".

By 5, 10, 20, 50, 100, 200, 400, 500, 600 contour mesh or contour non-jawed packages together with an equal number of instructions forapplication in hermetically sealed plastic bag made of light-proof polyethylene film.

It is allowed to put the full text of the instructions for use on the contour non-jawed packaging, bundle, bag.

Polyethylene bags are placed in a cardboard box.

Storage conditions:

In dry, dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years. Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-006251/10

Date of registration:01.07.2010

Expiration Date:Unlimited

The owner of the registration certificate:LYUMI, LLC LYUMI, LLC Russia

Manufacturer: & nbsp

LYUMI, LLC Russia

Information update date: & nbsp23.11.2017

Illustrated instructions

Instructions

Calcium gluconate (Calcium gluconate)