Calcium gluconate stabilized - instructions for use, dose, side effects, contraindications

Pharmacodynamics:Calcium ions are involved in the transmission of nerve impulses, the contraction of smooth and skeletal muscles, the functioning of the myocardium, the coagulation of blood; they are necessary for the formation of bone tissue, the functioning of other systems and organs.The concentration of calcium ions in the blood decreases with many pathological processes, and pronounced hypocalcemia contributes to the onset of tetany. Calcium gluconate, except for the elimination of hypocalcemia, reduces the permeability of blood vessels, has anti-allergic, anti-inflammatory, hemostatic effect. In contrast, calcium chloride has a weaker local irritant effect, so it can be used for intramuscular and subcutaneous injection.

Pharmacokinetics:After parenteral administration, the drug with blood flow is evenly distributed in all tissues and organs. In the blood plasma calcium is in ionized form. Passes through the placental barrier, enters the breast milk. It is excreted from the body mainly by the kidneys.

Indications:

Calcium gluconate is used with insufficient parathyroid function, increased excretion of calcium from the body, as an auxiliary for allergic diseases and allergic complications of drug therapy, to reduce the permeability of blood vessels in pathological processes of various genesis; with parenchymal hepatitis, toxic lesions of the liver, nephritis, eclampsia, hyperkalemia,hyperkalemic form of paroxysmal myoplegia, with skin diseases, as a hemostatic agent, and also as an antidote for poisoning with magnesium salts, oxalic acid or its soluble salts, soluble salts of fluoric acid.

Contraindications:

Tendency to thrombosis, hypercalcemia, severe atherosclerosis, increased blood coagulability.

Pregnancy and lactation:

The use of the drug in pregnant women and during breastfeeding is not contraindicated in therapeutic doses.

Dosing and Administration:

Intravenous and intramuscularly, adults receive 5-10 ml of 10% solution once, depending on the nature of the disease and the patient's condition - every day, every other day, or 2 days later.

Children intramuscularly administer the drug is not recommended because of the possible development of necrosis. Children intravenously, depending on the age, a 10-% solution of calcium gluconate administered in such doses: up to 6 months - 0.1 - 1 ml, at 7 - 12 months - 1 - 1.5 ml, in 1 - 3 years - 1 , 5-2 ml, in 1 - 3 years - 1,5-2 ml, in 4 - 6 years -2-2,5 ml, at 7 - 14 years 3-5 ml.

Side effects:

Sometimes there may be nausea, vomiting, diarrhea, bradycardia, a feeling of heat in the mouth, and then throughout the body, which quickly pass by themselves.

Overdose:

In case of an overdose, hypercalcemia may develop.In this case, the antidote is used calcitonin, which is administered intravenously at the rate of 5-10 ME per 1 kg of body weight per day (the drug is diluted in 500 ml of isotonic sodium chloride solution, administered dropwise for 6 hours in 2 to 4 doses).

Interaction:

Before filling with the calcium solution of the gluconate of the syringe, the syringe should not contain the remains of ethyl alcohol (precipitation of gluconate). It is not recommended to appoint calcium together with other drugs. Intravenous administration of calcium gluconate before and after taking verapamil reduces its hypotensive effect, but does not affect its antiarrhythmic effect. With simultaneous application with quinidine, it is possible to slow intraventricular conduction and increase the toxicity of quinidine. During the treatment with cardiac glycosides, the parenteral administration of calcium gluconate is not recommended in connection with the intensification of cardiotoxic action. With the simultaneous oral administration of calcium gluconate and tetracyclines, the effect of the latter may decrease due to a decrease in their absorption.

Special instructions:

The preparation is heated to the body temperature before administration. Adults and children are injected slowly, for 2-3 minutes.

With intravenous administration, a feeling of heat can be felt throughout the body, which quickly passes.

Form release / dosage:Solution for injection 100 mg / ml.

Packaging:

5 ml or 10 ml in ampoules with a ring or break point.

For 5 or 10 ampoules, together with instructions for medical use, put in a pack with a corrugated cardboard insert.

5 ampoules are put in a blister made of polymer material. For I or 2 blisters with ampoules, along with the instructions for medical use, they are placed in a pack of cardboard.

Storage conditions:

Store in a place protected from light and out of reach of children, at a temperature of 15 ° C to 25 ° C.

Shelf life:3 years.

Terms of leave from pharmacies:On prescription

Registration number:LSR-002447/08

Date of registration:03.04.2008 / 08.04.2015

Expiration Date:Unlimited

The owner of the registration certificate:FARMAK, PAO FARMAK, PAO Ukraine

Manufacturer: & nbsp

FARMAK, PAO Ukraine

Information update date: & nbsp23.11.2017

Illustrated instructions

Instructions

Calcium gluconate, stabilized (Calcium gluconate stabilisate)