Calcium gluconate - instructions for use, dose, side effects, contraindications

The preparation of calcium replenishes the deficiency of calcium ions necessary for the process of nerve impulse transmission, reduction of skeletal and smooth muscles, myocardial activity, bone formation, and blood coagulation.

Pharmacokinetics:

Approximately 1 / 5-1 / 3 part of the orally administered drug is absorbed in the small intestine; this process depends on the presence of the vitamin D, pH, features of the diet and the presence of factors that can bind calcium ions. The absorption of calcium increases with its deficiency and the use of a diet with a reduced content of calcium. About 20% is excreted by the kidneys, the rest (80%) is removed from the intestinal contents (actively allocated by the wall of the terminal gastrointestinal tract (GIT)).

Indications:

Diseases accompanied by hypocalcemia, increased permeability of cell membranes (including blood vessels), impaired conduction of nerve impulses in muscle tissue.
Hypoparathyroidism (latent tetany, osteoporosis), metabolic disturbances of vitamin D: rickets (spasmophilia, osteomalacia), hyperphosphataemia in patients with chronic renal insufficiency.
Increased need for calcium ions (pregnancy, lactation period, period of increased growth of the body), insufficient calcium content in food, violation of its metabolism (in the postmenopausal period).
Increased excretion of calcium ions (prolonged bed rest, chronic diarrhea,secondary hypocalcemia on the background of long-term use of diuretics and antiepileptic medicines (LS), glucocorticoid agents).
Bleeding of various etiologies; allergic diseases (serum sickness, urticaria, febrile syndrome, itching, itching dermatoses, reactions to drug administration and food intake, angioedema); bronchial asthma, dystrophic alimentary swelling, pulmonary tuberculosis, lead colic; eclampsia.
Poisoning with magnesium salts, oxalic and fluoric acids and their soluble salts (in the interaction with calcium gluconate insoluble and non-toxic calcium oxalate and calcium fluoride are formed).
Parenchymal hepatitis, toxic liver damage, nephritis, hyperkalemic form of proximal myoplegia.

Contraindications:

Hypersensitivity,
hypercalcemia (concentration of calcium ions should not exceed 12 mg% or 6 mEq / l),
pronounced hypercalciuria,
nefrourolitiaz (calcium),
sarcoidosis,
simultaneous reception of cardiac glycosides (risk of arrhythmias),
children up to three years.

Carefully:

Dehydration,
electrolyte disorders (risk of hypercalcemia),
diarrhea,
malabsorption syndrome,
calcium nephrourolythiasis (in the anamnesis),
minor hypercalciuria,
moderate chronic renal failure,
chronic heart failure,
widespread atherosclerosis,
hypercoagulation.

Dosing and Administration:

Inside, before meals or 1-1,5 hours after taking (squeezed milk).

Adults - 1-3 g 2-3 times a day; children 3-4 years old - 1 g; 5-6 years - 1-1.5 g; 7-9 years - 1.5-2 g; 10-14 years - 2-3 g; the frequency of reception is 2-3 times a day.

Side effects:

From the digestive tract: constipation, irritation of the mucous membrane of the gastrointestinal tract.

Overdose:

Symptoms: hypercalcemia.

Treatment: parenterally - 5-10 IU / kg / day of calcitonin (diluting it in 500 ml of 0.9% sodium chloride solution). Duration of administration 6 hours.

Interaction:

With simultaneous application calcium gluconate pharmaceutically incompatible with carbonates, salicylates, sulfates (forms insoluble or hardly soluble calcium salts). When used simultaneously with tetracycline antibiotics calcium gluconate forms insoluble complexes (reduces antibacterial effect).

When used simultaneously with quinidine, it is possible deceleration intraventricular conduction and increased toxicity of quinidine.

With simultaneous application calcium gluconate slows down absorption of tetracyclines, digoxin, oral iron preparations (the interval between their administration should be at least 2 hours).

With simultaneous use with thiazide diuretics calcium gluconate can amplify hypercalcemia.

With simultaneous application calcium gluconate can reduce: the effect of calcitonin in hypercalcemia; bioavailability of phenytoin.

Special instructions:

Patients with minor hypercalciuria, reduced glomerular filtration, or with nephrourolythiasis in the history of the drug should be administered under the control of the concentration of calcium ions in the urine.

Drinking plenty is recommended to reduce the risk of nephrourolythiasis.

Form release / dosage:

Tablets of 0.5 g.

Packaging:

For 10 tablets in a planar cell package.

For 10 tablets in contour non-jammed packaging.

1, 2, 3, 5 or 10 contour packs, together with instructions for use, are placed in a pack of cardboard boxes.

500, 600, 800 or 1000 contour packs, together with an equal number of instructions for use, are placed in a group package.

Storage conditions:

In a dry place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:

5 years.

Do not use after the expiration date indicated on the label.

Terms of leave from pharmacies:Without recipe

Registration number:P N003414 / 01

Date of registration:26.06.2009 / 24.08.2016

Expiration Date:Unlimited

The owner of the registration certificate:MEDISORB, CJSC MEDISORB, CJSC Russia

Manufacturer: & nbsp

MEDISORB, CJSC Russia

Information update date: & nbsp23.11.2017

Illustrated instructions

Instructions

Calcium gluconate (Calcium gluconate)