Calcium gluconate Extragrant - instructions for use, dose, side effects, contraindications

The source of calcium ions, refers to the means regulating metabolic processes. Replenishes the deficiency of calcium, necessary for the process of transmission of nerve impulses, reduction of skeletal and smooth muscles, contractility of the myocardium, formation of bone tissue, clotting of blood.

In addition, it has anti-allergic and anti-inflammatory effects.

Pharmacokinetics:

After oral administration, about 30% of ionized calcium is absorbed in the gastrointestinal tract; this process depends on the presence of the vitamin D, pH, dietary characteristics and the presence of factors that are able to bind calcium. The absorption of calcium increases with its deficiency and the use of a diet with a reduced content of calcium. After oral administration, the maximum concentration in the blood plasma is reached after 1.2-1.3 hours. It penetrates through the placental barrier, is excreted in breast milk.

About 20% is excreted by the kidneys, the remaining amount (80%) is removed from the intestinal contents (actively allocated by the wall of the terminal section of the gastrointestinal tract).

Indications:

Diseases accompanied by hypocalcemia, increased permeability of cell membranes (incl.vessels), a violation of the conduction of nerve impulses in the muscle tissue.
Hypoparathyroidism (latent tetany, osteoporosis), metabolic disturbances of vitamin D: rickets (spasmophilia, osteomalacia), hyperphosphataemia in patients with chronic renal insufficiency.
The increased need for calcine (pregnancy, lactation, a period of increased body growth), insufficient calcium in food, a violation of its metabolism (in the postmenopausal period).
Enhanced excretion of calcium (prolonged bed rest, chronic diarrhea, secondary hypocalcemia, long-term use of diuretics and antiepileptic drugs, glucocorticosteroids).
Bleeding, which does not require parenteral administration of drugs (as part of complex therapy); allergic diseases (serum sickness, urticaria, febrile syndrome, itching, itching dermatoses, reactions to the administration of medicines and food intake, bronchial asthma) as part of complex therapy; dystrophic alimentary swelling, pulmonary tuberculosis, lead colic; prevention of eclampsia.
Poisoning with magnesium salts, oxalic and fluoric acids and their soluble salts (in the interaction with calcium gluconate insoluble and non-toxic calcium oxalate and calcium fluoride are formed).
Parenchymal hepatitis, toxic liver damage, nephritis, hyperkalemic form of proximal myoplegia.

Contraindications:

Increased individual sensitivity to one of the components of the drug, hypercalcemia (calcium concentration should not exceed 12 mg% = 6 mEq / L), expressed hypercalciuria, nephrourolythiasis (calcium), sarcoidosis, simultaneous reception of cardiac glycosides (risk of arrhythmias), children under 3 years.

Carefully:

Dehydration, electrolyte disorders (risk of hypercalcemia), diarrhea, malabsorption syndrome, calcium nephrourolythiasis (in the anamnesis), minor hypercalciuria, moderate CRF, CHF, prevalent atherosclerosis, hypercoagulation.

Dosing and Administration:

Inside, before meals or 1-1.5 hours after eating. Before swallowing, the tablets are chewed, washed down with a small amount of water or milk. ATadult - 1-3 g 2-3 times a day.

Children 3-4 years - 1 g; 5-6 years - 1-1.5 g; 7-9 years - 1.5-2 g; 10-14 years - 2-3 g; the frequency of reception is 2-3 times a day.

Side effects:

With prolonged use of calcium gluconate, constipation, irritation of the mucous membrane of the gastrointestinal tract, and sometimes the formation of calcified stones in the intestine.

Overdose:

Excessive long-term use of calcium preparations can lead to hypercalcemia with the deposition of calcium salts in organs and vessels.

Symptoms of overdose: drowsiness, weakness, anorexia, nausea, vomiting, constipation, polyuria, dehydration, cardiac rhythm disturbances are possible.

Treatment: Antidote is used calcitonin iv in the calculation of 5-10 IU / kg (diluting it in 500 ml of 0.9% sodium chloride solution). Duration of administration 6 hours.

Interaction:

Forms insoluble or hardly soluble calcium salts with carbonates, salicylates, sulfates.

Reduces the antibacterial effect of tetracycline antibiotics, forming insoluble complexes with them.

With simultaneous application with quinidine, it is possible to slow intraventricular conduction and increase the toxicity of quinidine.

Slows down the absorption of tetracyclines, digoxin.oral iron preparations (the interval between their methods should be at least 2 hours).

When combined with thiazide diuretics can increase hypercalcemia, reduce the effect of calcitonin in hypercalcemia. reduces the bioavailability of phenytoin.

Special instructions:

Patients with minor hypercalciuria, reduced glomerular filtration or with nephrourolythiasis in history should be administered under the control of the concentration of calcium in the urine.

Drinking plenty is recommended to reduce the risk of nephrourolythiasis.

Form release / dosage:Chewable tablets (orange, mint, apple) 500 mg.

Packaging:

For 4, 6 or 10 tablets in a planar cell packaging made of polyvinylchloride film and aluminum foil printed lacquered.

By 1, 2, 3, 4, 5 contour packs with instructions for use in a pack of cardboard.

Storage conditions:

In a dry, protected from light place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-000287/10

Date of registration:25.01.2010 / 11.05.2012

Expiration Date:Unlimited

The owner of the registration certificate:OBOLENSKOE PHARMACEUTICAL ENTERPRISE, CJSC OBOLENSKOE PHARMACEUTICAL ENTERPRISE, CJSC Russia

Manufacturer: & nbsp

OBOLENSKOE PHARMACEUTICAL ENTERPRISE, CJSC Russia

Information update date: & nbsp23.11.2017

Illustrated instructions

Instructions

Calcium gluconate Extrabate (Calcium gluconate Extratab)