Calcium gluconate - instructions for use, dose, side effects, contraindications

The preparation of calcium replenishes the deficiency of calcium ions necessary for the realization of the process of transmission of nerve impulses, reduction of skeletal and smooth muscles, myocardial activity, the formation of bone tissue, and the coagulation of blood.

With intravenous injection stimulates the sympathetic department of the autonomic nervous system, increases adrenal secretion of adrenaline, has a moderate diuretic effect.

Pharmacokinetics:After parenteral administration calcium gluconate with blood flow evenly distributed in all tissues and organs. In the blood plasma calcium is in ionized form. Passes through the placental barrier, enters the breast milk. It is excreted from the body mainly by the kidneys.

Indications:

Diseases accompanied by hypocalcemia, increased permeability of cell membranes (including blood vessels), impaired conduction of nerve impulses in muscle tissue.

Hypoparathyroidism (latent tetany, osteoporosis), metabolic disturbances of the vitamin D: rickets (spasmophilia, osteomalacia), hyperphosphataemia in patients with chronic renal insufficiency.

Increased need for calcium (pregnancy, lactation period, period of increased body growth), insufficient food, violation, calcium metabolism (in the postmenopausal period).

Enhanced excretion of calcium (prolonged bed rest, chronic diarrhea,secondary hypocalcemia on the background of long-term use of diuretics and antiepileptic drugs, glucocorticosteroids).

Bleeding of various etiologies; allergic diseases (serum sickness, urticaria, febrile syndrome, itching, itching dermatoses, reactions to medication administration and food intake, angioedema); dystrophic alimentary swelling, pulmonary tuberculosis, lead colic; eclampsia.

Hyperkaliemic form of paroxysmal myoplegia.

Contraindications:

Hypersensitivity to the drug components, hypercalcemia (concentration calcium ions should not exceed 12 mg% or 6 mEq / L), expressed hypercalciuria, nefrourolitiaz (calcium), sarcoidosis, simultaneous reception of cardiac glycosides (risk of arrhythmias).

If you have any of these diseases, consult a doctor before taking the drug.

Carefully:

Dehydration, electrolyte disorders (risk of hypercalcemia), diarrhea, malabsorption syndrome, calcium nephrourolythiasis (in the anamnesis), hypercalciuria, moderate chronic renal failure,chronic heart failure, widespread atherosclerosis, hypercoagulability, for intramuscular injection - children's age (risk of necrosis).

If you have any of these diseases, consult a doctor before taking the drug.

Pregnancy and lactation:The application is allowed.

Dosing and Administration:

Adults: intramuscularly, intravenously (slowly for 2-3 minutes) or drip 5-10 ml of 10% solution daily, every other day or 2 days, depending on the nature of the disease and the patient's condition.

Children: intravenously (slowly for 2-3 minutes) or drip from 1 to 5 ml (depending on the age) 10% solution every 2-3 days.

The solution before the introduction is warmed to body temperature.

The syringe for administration should not contain ethanol residues (in order to avoid calcium gluconate precipitation).

Children intramuscularly administer the drug is not recommended because of the possible development of necrosis.

Side effects:

With intramuscular and intravenous administration, nausea, vomiting, diarrhea, bradycardia are possible.

With intravenous administration, burning in the oral cavity, a sensation of heat, with rapid intravenous administration - lowering of arterial pressure, arrhythmia, fainting, cardiac arrest are possible.With intramuscular injection, at the site of injection, necrosis can form.

If any of the side effects indicated in the manual are aggravated or you notice any other side effects not listed in the instructions, inform your doctor.

Overdose:

Symptoms: hypercalcemia.

Treatment: parenterally, 5-10 IU / kg body weight per day calcitonin (the drug is diluted in 500 ml of 0.9% sodium chloride solution, injected drip for 6 hours).

Interaction:

Pharmaceutically incompatible with carbonates, salicylates, sulfates, ethanol (forms insoluble or hardly soluble calcium salts).

Forms insoluble complexes with antibiotics of the tetracycline series (reduces the antibacterial effect).

Reduces the effect of blockers of "slow" calcium channels (intravenous calcium gluconate before or after verapamil reduces its hypotensive effect).

With simultaneous application with quinidine, it is possible to slow intraventricular conduction and increase the toxicity of quinidine.

During the treatment with cardiac glycosides, parenteral calcium gluconate is not recommended (cardiotoxic effect of cardiac glycosides may be increased).

When combined with thiazide diuretics can increase hypercalcemia.

Reduces the effect of calcitonin in hypercalcemia.

Reduces the bioavailability of phenytoin.

Special instructions:

Patients with minor hypercalciuria, reduced glomerular filtration or with nephrourolythiasis in history should be administered under the control of the concentration of calcium in the urine. Drinking plenty is recommended to reduce the risk of nephrourolythiasis.

Form release / dosage:

Solution for intravenous and intramuscular injection 100 mg / ml.

Packaging:

For 10 ml in ampoules of neutral glass. 10 ampoules in a cardboard bundle with corrugated ribbon or paper insert, or with 5 ampoules in a contour acrylic package of polyvinylchloride film and foil of aluminum lacquered or paper wrapped with polymer coating, or without paper and foil, 2 packs per carton pack, together with instructions for use and an ampoule knife or scarifier.

When you pack the ampoules with a dot or rupture ring, do not put the ampoule knife or scarifier.

Storage conditions:

In the dark place at a temperature of 8 to 30 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:LP-000168

Date of registration:13.01.2011

The owner of the registration certificate:TRIM, LLC TRIM, LLC Russia

Manufacturer: & nbsp

ARMAVIRSK BIOLOGICAL FACTORY, FSUE Russia

Information update date: & nbsp10.09.2015

Illustrated instructions

Instructions

Calcium gluconate (Calcium gluconate)