Calcium gluconate - instructions for use, dose, side effects, contraindications

Excipients: cellulose microcrystalline - 72.0 mg, povidone (polyvinylpyrrolidone) - 18.0 mg, silicon dioxide colloid - 4.0 mg, magnesium stearate - 6.0 mg.

Description:Round flat tablets of white or almost white color with a risk on one side and chamfers from two sides, marble is allowed.

Pharmacotherapeutic group:Calcium-phosphorus exchange regulator

ATX: & nbsp

A.12.A.A.03 Calcium gluconate

A.12.A.A Calcium preparations

Pharmacodynamics:

The preparation of calcium replenishes the deficiency of calcium ions necessary for the process of nerve impulse transmission, reduction of skeletal and smooth muscles, myocardial activity, bone formation, and blood coagulation.

Pharmacokinetics:

Approximately 1 / 5-1 / 3 part of the orally administered drug is absorbed into the small intestine; this process depends on the presence of the vitamin D, pH, features of the diet and the presence of factors that can bind calcium ions. The absorption of calcium ions increases with its deficiency and the use of a diet with a reduced content of calcium ions. About 20% is excreted by the kidneys, the rest (80%) is the intestine.

Indications:

- Diseases accompanied by hypocalcemia, increased permeability of cell membranes (including blood vessels), impaired conduction of nerve impulses in muscle tissue.

- Hypoparathyroidism (latent tetany, osteoporosis), metabolic disturbances of the vitamin D: rickets (spasmophilia, osteomalacia), hyperphosphatemia in patients with chronic renal insufficiency.

- Increased need for calcium ions (pregnancy, the period of breastfeeding, the period of increased body growth), insufficient calcium ions in food, a violation of its metabolism (in the postmenopausal period).

- Increased excretion of calcium ions (prolonged bed rest, chronic diarrhea, secondary hypocalcemia, long-term use of diuretics and antiepileptic drugs, glucocorticosteroids).

- Poisoning with magnesium salts, oxalic and hydrofluoric acids and their soluble salts (in the interaction with calcium gluconate insoluble and non-toxic calcium oxalate and calcium fluoride are formed).

Hyperkaliemic form of paroxysmal myoplegia.

Contraindications:

Hypersensitivity to the drug components, hypercalcemia (calcium concentration should not exceed 12 mg% or 6 mEq / L), expressed hypercalciuria, nephrourolythiasis (calcium), severe renal failure, sarcoidosis, simultaneous reception of cardiac glycosides (risk of arrhythmias), children under 3 years old.

Carefully:

Dehydration, electrolyte disorders (risk of development hypercalcaemia), diarrhea, malabsorption syndrome, calcium nephrourolythiasis (in the anamnesis), minor hypercalciuria, moderate chronic renal failure, chronic heart failure, prevalent atherosclerosis, hypercoagulation.

Pregnancy and lactation:

The use of the drug is permissible taking into account the ratio of the benefits for the woman / risk to the fetus (child), which is determined by the doctor.When taking calcium supplements during the period of breastfeeding, it is possible that it penetrates into breast milk.

Dosing and Administration:

Inside, before meals or 1-1.5 hours after taking (squeezed milk).

Doses are determined by the attending physician individually depending on the clinical picture.

Hypoparathyroidism (latent tetany, osteoporosis): adults 1-3 g 2-3 times a day; children 3-4 years old - 1 g; 5-6 years - 1-1.5 g; 7-9 years - 1.5-2 g; 10-14 years - 2-3 g; the frequency of reception is 2-3 times a day.

Violation of the metabolism of the vitamin D: rickets (spazmofiliya, osteomalacia), hyperphosphatemia in patients with chronic renal failure ' adults 1-3 g 2-3 times a day; children 3-4 years old - 1 g; 5-6 years - 1-1.5 g; 7-9 years - 1.5-2 g; 10-14 years - 2-3 g; the frequency of admission is 2-3 times a day.

Increased need for calcium (Pregnancy, lactation, the period of intensive growth of the organism), the lack of calcium in the diet, a violation of its exchange: adults - 1-3 g 2-3 times a day; children 3-4 years old - 1 g; 5-6 years - 1-1.5 g; 7-9 years - 1.5-2 g; 10-14 years - 2-3 g; the frequency of admission is 2-3 times a day.

Enhanced excretion of calcium (Prolonged bed rest, chronic diarrhea, secondary hypocalcaemia amid prolonged use of diuretics and anti-epileptic drugs, glucocorticoids): adults - 1-3 g 2-3 times a day; children 3-4 years old - 1 g; 5-6 years - 1-1.5 g; 7-9 years - 1.5-2 g; 10-14 years - 2-3 g; the frequency of admission is 2-3 times a day.

Poisoning with magnesium, oxalic and fluoric acids and their soluble salts: adults 1-3 g 2-3 times a day; children 3-4 years old - 1 g; 5-6 years - 1-1.5 g; 7-9 years - 1.5-2 g; 10-14 years - 2-3 g; the frequency of admission is 2-3 times a day.

Hyperkaliemic form of paroxysmal myoplegia: adults 1-3 g 2-3 times a day; children 3-4 years old - 1 g; 5-6 years - 1-1.5 g; 7-9 years - 1.5-2 g; 10-14 years - 2-3 g; the frequency of reception is 2-3 times a day.

Side effects:Constipation, irritation of the mucous membrane of the gastrointestinal tract, hypercalcemia.

Overdose:

Symptoms: hypercalcemia (drowsiness, weakness, anorexia, abdominal pain, vomiting, nausea, constipation, polydipsia, polyuria, fatigue, irritability, poor health, depression, dehydration, possible heart rhythm disturbance, myalgia, arthralgia, arterial hypertension).

Treatment: drug cancellation; in severe cases - parenterally calcitonin in a dose of 5-10 IU / kg body weight per day (when diluted in 500 ml sterile 0.9% saline solution of sodium chloride), intravenously drip for 6 hours. Intravenous-jet infusion is possible 2-4 times a day.

Interaction:

Pharmaceutically incompatible with carbonates, salicylates, sulfates (forms insoluble or hardly soluble calcium salts).

Forms insoluble complexes with antibiotics of the tetracycline series (reduces the antibacterial effect).

Reduces the effect of blockers of "slow" calcium channels.

With simultaneous application with quinidine, it is possible to slow intraventricular conduction and increase the toxicity of quinidine.

Slows the absorption of tetracyclines, digoxin, oral iron preparations (the interval between their methods should be at least 2 hours).

When combined with thiazide diuretics can increase hypercalcemia. Reduces the effect of calcitonin in hypercalcemia.

Reduces the bioavailability of phenytoin.

Special instructions:

In patients with minor hypercalciuria, a decrease in glomerular filtration or with nephrourolythiasis in history, treatment should be controlled by the concentration of calcium ions in the urine.

Drinking plenty is recommended to reduce the risk of nephrourolythiasis.

Effect on the ability to drive transp. cf. and fur:

The drug does not affect the driving of vehicles and the management of mechanisms.

Form release / dosage:

Tablets 500 mg.

Packaging:

For 10 tablets in a contour mesh box made of polyvinylchloride film and aluminum foil printed lacquered.By 10, 20, 30, 40, 50, 60, 70, 80, 90 or 100 tablets in cans of polymeric for medicines. One bank or 1,2, 3, 4, 5, 6, 7, 8, 9, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100 contour cell packs together with the instruction for use are placed in cardboard packaging (bundle).

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:

3 years. Do not use the drug after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LP-002285

Date of registration:28.10.2013

Expiration Date:28.10.2018

The owner of the registration certificate:ATOLL, LLC ATOLL, LLC Russia

Manufacturer: & nbsp

OZONE, LLC Russia

Information update date: & nbsp24.11.2017

Illustrated instructions

Instructions

Calcium gluconate (Calcium gluconate)