Calcium gluconate - instructions for use, dose, side effects, contraindications

The preparation of calcium replenishes the deficiency of calcium ions necessary for the process of nerve impulse transmission, reduction of skeletal and smooth muscles, myocardial activity, bone formation, and clotting of blood.

Pharmacokinetics:

After parenteral administration, the drug with blood flow is evenly distributed in all tissues and organs. In blood plasma, about 45% of calcium ions are in complex with proteins. Passes through the placental barrier, enters the breast milk. It is excreted from the body mainly by the kidneys.

Indications:

Diseases accompanied by hypocalcemia, increased permeability of cell membranes (including blood vessels), impaired conduction of nerve impulses in muscle tissue.

Hypoparathyroidism (latent tetany, osteoporosis), a violation of vitamin exchange D: rickets (spasmophilia, osteomalacia), hyperphosphatemia in patients with chronic renal insufficiency.

The increased need for calcium (pregnancy, lactation, the period of intensive growth of the organism), the lack of calcium in the diet, the violation of its exchange (post-menopausal). Increased excretion of calcium (prolonged bed rest, chronic diarrhea, secondary hypocalcaemia amid prolonged use of diuretics and anti-epileptic drugs, glucocorticoids).

Bleeding of various etiologies; allergic diseases (serum sickness, urticaria, febrile syndrome, itching,itching dermatosis, reactions to the administration of medicines and the intake of food products, angioedema, edema); bronchial asthma, dystrophic alimentary swelling, pulmonary tuberculosis, rickets, osteomalacia, lead colic; eclampsia.

Hyperkaliemic form of paroxysmal myoplegia.

Contraindications:

Hypersensitivity, hypercalcemia (concentration of Ca²⁺ should not exceed 12 mg% or 6 mEq / L), expressions of hypercalciuria, nephrourolythiasis (calcium), sarcoidosis, simultaneous reception of cardiac glycosides (risk of arrhythmias).

Carefully:

Dehydration, electrolyte disorders (risk of hypercalcemia), diarrhea, malabsorption syndrome, calcium nephrourolythiasis (in the anamnesis), minor hypercalciuria, moderate chronic renal failure, chronic circulatory failure, widespread atherosclerosis, hypercoagulation, childhood (for intramuscular injection, the risk of necrosis) .

Dosing and Administration:

Intramuscularly, intravenously slowly (for 2-3 min) or drip adult - 5-10 ml of 10% solution daily, every other day or 2 days (depending on the nature of the disease and the patient's condition).Children - intravenously slowly (within 2-3 minutes) or drip, depending on the age, from 1 to 5 ml of 10% solution every 2-3 days. The solution before the introduction is warmed to body temperature. The syringe for the administration of calcium gluconate should not contain ethanol residues (in order to avoid the precipitation of calcium gluconate). Children intramuscularly administer the drug is not recommended because of the possible development of necrosis.

Side effects:

With intramuscular and intravenous administration - nausea, vomiting, diarrhea, bradycardia can be observed. With intravenous administration, burning in the oral cavity, a sensation of fever, with a rapid intravenous injection - a decrease in blood pressure, arrhythmia, fainting, cardiac arrest can be observed. With intramuscular injection, necrosis can be formed at the site of administration.

Overdose:

Symptoms: hypercalcemia.

Treatment: parenterally 5-10 IU / kg / day. calcitonin (diluting it in 500 ml of 0.9% sodium chloride solution). Duration of administration is 6 hours.

Interaction:

It is pharmaceutically incompatible with ethanol, carbonates, salicylates, sulfates (it forms insoluble or hardly soluble calcium salts).

Forms insoluble complexes with antibiotics of the tetracycline series (reduces the antibacterial effect).

Reduces the effect of blockers of "slow" calcium channels (intravenous calcium gluconate before or after verapamil reduces its hypotensive effect).

With simultaneous application with quinidine, it is possible to slow intraventricular conduction and increase the toxicity of quinidine.

During the treatment with cardiac glycosides, parenteral calcium gluconate is not recommended (cardiotoxic effect of cardiac glycosides may be increased).

When combined with thiazide diuretics can increase hypercalcemia, reduce the effect of calcitonin in hypercalcemia, reduces the bioavailability of phenytoin.

Special instructions:

Patients with minor hypercalciuria, reduced glomerular filtration or with nephrourolythiasis in anamnesis should be administered with caution and under the control of calcium in the urine.

Drinking plenty is recommended to reduce the risk of nephrourolythiasis.

Form release / dosage:Solution for intravenous and intramuscular injection 100 mg / ml.

Packaging:

Solution for intravenous and intramuscular injection 100 mg / ml in ampoules of 5 or 10 ml. 5 ampoules per contour cell pack of polyvinyl chloride film. 1 or 2 contoured cell packs with scarifier ampoule ceramic or knife for opening ampoules and instructions for use in a pack of cardboard. When using ampoules with a fracture ring or break point, the knife or scarifier is not inserted.

Storage conditions:

Store in a dark place at a temperature of 20 to 35 ° C. Keep out of the reach of children.

Shelf life:

2 years. Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:PL-000410

Date of registration:28.02.2011

The owner of the registration certificate:BINNOFARM, CJSC BINNOFARM, CJSC Russia

Manufacturer: & nbsp

BINNOFARM, CJSC Russia

Information update date: & nbsp10.09.2015

Illustrated instructions

Instructions

Calcium gluconate (Calcium gluconate)