Calcium gluconate - instructions for use, dose, side effects, contraindications

Calcium supplement, a calcium and phosphorus metabolism regulator, replenishes the deficiency of calcium ions (Ca 2+) necessary for the process of nerve impulse transmission, reduction of skeletal and smooth muscles, myocardial activity, bone formation, and blood clotting.

Pharmacokinetics:

Approximately 20% -30% of the orally administered drug is absorbed in the small intestine; this process depends on the presence of the vitamin D, pH, features of the diet and the presence of factors that can bind Ca 2+. Absorption of Ca 2+ increases with its deficiency and use of diet, poor Ca 2+. About 20% is excreted by the kidneys, the remaining amount (80%) is removed from the intestinal contents (actively allocated by the wall of the terminal section of the gastrointestinal tract).

Indications:

Diseases accompanied by hypocalcemia, increased permeability of cell membranes (including blood vessels), impaired conduction of nerve impulses in muscle tissue.

Hypofunction of the parathyroid glands (latent tetany, osteoporosis), metabolic disturbances of the vitamin D: rickets (spasmophilia, osteomalacia), hyperphosphatemia in patients with chronic renal insufficiency.

Increased demand for Ca2 + (pregnancy, lactation period, period of increased body growth), insufficient Ca2 + content in food, impaired metabolism (in the postmenopausal period).

Enhanced excretion of Ca2 + (prolonged bed rest, chronic diarrhea, secondary hypocalcemia, long-term use of diuretics and antiepileptic drugs, glucocorticosteroids).

Bleeding of various etiologies; allergic diseases (serum sickness, urticaria, febrile syndrome, itching, itching dermatoses, reactions to medication administration and food intake, Quincke's edema); bronchial asthma, dystrophic alimentary swelling, pulmonary tuberculosis, lead colic; eclampsia.

Salt poisoning Mg2+, oxalic and fluoric acids and their soluble salts (in the interaction with calcium gluconate insoluble and non-toxic calcium oxalate and calcium fluoride are formed).

Parenchymal hepatitis, toxic liver damage, nephritis, hyperkalemic form of paroxysmal myoplegia.

Contraindications:

Hypersensitivity, hypercalcemia (concentration of Ca2 + should not exceed 12 mg% or 6 mEq / L), hypercalciuria, nephrolithiasis (calcium), sarcoidosis, intoxication with cardiac glycosides (risk of arrhythmias).

Carefully:

Dehydration, electrolyte disorders (risk of hypercalcemia), diarrhea, malabsorption syndrome, minor hypercalciuria, mild chronic renal failure, chronic heart failure, prevalent atherosclerosis, hypercoagulation.

Dosing and Administration:

Inside, before meals or after 1-1.5 hours after intake (squeezed milk), adults - 1-3 g 2-3 times a day.

Children under 1 year - 0.5 g; 2-4 years - 1 g; 5-6 years - 1-1.5 g; 7-9 years - 1.5-2 g; 10-14 years - 2-3 g; the frequency of reception is 2-3 times a day.

Side effects:

Constipation, irritation of the mucous membrane of the gastrointestinal tract, nausea, vomiting, diarrhea, pain in the upper abdomen.

Overdose:

Symptoms: the development of hypercalcemia.

Treatment: calcitonin, intravenously from the calculation 5-10 ME / kg / day (the drug is diluted in 500 ml of 0.9% sodium chloride solution, injected drip for 6 hours).

Interaction:

Pharmaceutically incompatible with ethanol, carbonates, salicylates, sulfates (forms insoluble or sparingly soluble salts of Ca2 +).

Forms insoluble complexes with antibiotics of the tetracycline series (reduces the antibacterial effect).

With simultaneous application with quinidine, it is possible to slow intraventricular conduction and increase the toxicity of quinidine.

Slows the absorption of tetracyclines, digoxin, oral iron preparations (the interval between their methods should be at least 2 hours). When combined with thiazide diuretics can enhance hypercalcemia, reduce the effect of calcitonin in hypercalcemia, reduces the bioavailability of phenitonin.

Special instructions:

Patients with minor hypercalciuria, decreased glomerular filtration, or with nephrolithiasis in an anamnesis should be administered with caution and under the control of Ca 2+ concentration in the urine.

Drinking plenty is recommended to reduce the risk of developing nephrolithiasis.

Form release / dosage:Tablets 0.5 g.

Packaging:

For 10 tablets in a contour cell or cellulose package. 2 contour non-jaw or cell packs with instructions for use are placed in a pack of cardboard. By 700 contour non-jawed or 1000 contour mesh packages with an equal number of instructions for use are placed in a pack of cardboard.

Storage conditions:Store in a dry place, at a temperature of 15 to 25 ° C. Keep out of the reach of children.

Shelf life:

5 years. Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-002034/08

Date of registration:21.03.2008 / 10.08.2017

Expiration Date:Unlimited

The owner of the registration certificate:AVEKSIMA, JSC AVEKSIMA, JSC Russia

Manufacturer: & nbsp

IRBITSK HFZ, OJSC Russia

Information update date: & nbsp23.11.2017

Illustrated instructions

Instructions

Calcium gluconate (Calcium gluconate)