Analgin - instructions for use, dose, side effects, contraindications

An analgesic non-narcotic agent, a derivative of pyrazolone, nonselectively blocks cyclooxygenase and reduces the formation of prostaglandins from arachidonic acid.

Prevents painful extra- and proprioretseptivepulses along the Gaull and Burdach bundles, raises the threshold of excitability of thalamic centers of pain sensitivity, increases heat transfer.

A distinctive feature is the insignificant severity of the anti-inflammatory effect, which causes a weak effect on water-salt metabolism (ion retention Na+ and water) and the mucous membrane of the gastrointestinal tract. Has analgesic, antipyretic and some spasmolytic (with respect to the smooth muscles of the urinary and bile ducts) action. The effect develops 20-40 minutes after ingestion and reaches a maximum after 2 hours.

Pharmacokinetics:

Good and quickly absorbed in the gastrointestinal tract. In the intestinal wall it hydrolyzes with the formation of an active metabolite - unchanged metamizol sodium in the blood is absent. The association of the active metabolite with proteins plasma - 50-60%

Metabolized in the liver, excreted by the kidneys. In therapeutic concentrations penetrates in mother's milk.

Indications:

Feverish syndrome (infectious and inflammatory diseases, insect bites - mosquitoes, bees, gadflies and other post-transfusion complications).

Pain syndrome (mild to moderate), incl. neuralgia, myalgia, arthralgia, biliary colic, intestinal colic, renal colic, trauma, burns, decompression sickness, shingles, orchitis, radiculitis, myositis, postoperative pain syndrome, headache, toothache, algodismenorea.

Contraindications:

Hypersensitivity to the components of the drug; oppression of hematopoiesis (agranulocytosis, cytostatic or infectious neutropenia), hepatic and / or renal failure, hereditary hemolytic anemia associated with deficiency of glucose-6-phosphate dehydrogenase; complete and incomplete combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (including in history); anemia, leukopenia, pregnancy, lactation, children under 8 years old.

Carefully:

Kidney disease (pyelonephritis, glomerulonephritis - including in the anamnesis), alcoholism.

Pregnancy and lactation:

Application during pregnancy and during lactation is contraindicated.

Dosing and Administration:

Inside after eating.Adults on 250-500 mg 2-3 times a day. The highest single dose for adults - 1 g, daily - 3 g.

Single doses for children 8-14 years - 250-300 mg 14-17 years - 250-500 mg, the frequency of reception - 2-3 times a day.

Side effects:

From the urinary system: renal dysfunction, oliguria, anuria, proteinuria, interstitial nephritis, urine staining in red.

Allergic reactions: urticaria (including on the conjunctiva and mucous membranes of the nasopharynx), angioedema, in rare cases - malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), bronchospastic syndrome, anaphylactic shock.

On the part of the organs of hematopoiesis: agranulocytosis, leukopenia, thrombocytopenia,

Other: lowering of blood pressure.

Overdose:

Symptoms: nausea, vomiting, gastralgia, oliguria, hypothermia, lowering of blood pressure, tachycardia, dyspnea, tinnitus, drowsiness; delirium, impaired consciousness, acute agranulocytosis; hemorrhagic syndrome, acute renal and / or hepatic insufficiency, convulsions, paralysis of the respiratory musculature.

Treatment: gastric lavage, saline laxatives, Activated carbon; conducting forced diuresis, hemodialysis, with the development of convulsive syndrome - intravenous diazepam and high-speed barbiturates.

Interaction:

Enhances the effects of ethanol.

Radiopaque preparations, colloidal blood substitutes and penicillin should not be used during treatment with metamizole sodium.

With the simultaneous use of cyclosporine, the concentration of the latter in the blood decreases. Metamizol sodium, displacing from the connection with plasma proteins, oral hypoglycemic drugs, indirect anticoagulants, glucocorticosteroids, indomethacin, increases their activity.

Phenylbutazone, barbiturates and other inducers of microsomal liver enzymes at the same time reduce the effectiveness of metamizole sodium.

Simultaneous use with other non-narcotic analgesics, tricyclic antidepressants, contraceptive hormonal drugs and allopurinol may lead to increased toxicity.

Sedative and anxiolytic drugs (tranquilizers) increase the analgesic effect of metamizole sodium.

Thiamazole and cytostatics increase the risk of developing leukopenia.

The effect is enhanced codeine, H2-histamine receptor blockers and propranolol (slows inactivation).

Myelotoxic drugs increase the manifestation of hematotoxicity of the drug.

Special instructions:

When treating children and patients receiving cytotoxic drugs, taking metamizole sodium should be done only under the supervision of a doctor.

Against the background of taking metamizole sodium, the development of agranulocytosis is possible, in connection with which, when an unmotivated rise in temperature, chills, sore throats, difficulty swallowing, stomatitis, as well as in the development of phenomena of vaginitis or proctitis, immediate withdrawal of the drug is necessary. With prolonged use, it is necessary to monitor the picture of peripheral blood.

It is inadmissible to use to relieve acute pain in the abdomen (until the cause is clarified). It is possible to stain urine in red by excretion of the metabolite (it has no value).

Effect on the ability to drive transp. cf. and fur:During the period of taking the drug, one should not perform work requiring increased attention and speed of psychomotor reactions.

Form release / dosage:Tablets by 500 mg.

Packaging:

10 tablets per contour cell or cell-free packaging.

1000 contour mesh or 500 non-jammed packages with an equal number of instructions for use are placed in a cardboard box.

Storage conditions:In a dry, dark place at a temperature of no higher than 25 ° C.

Shelf life:5 years. After expiration date the drug should not be used.

Terms of leave from pharmacies:On prescription

Registration number:P N003134 / 01

Date of registration:15.07.2009 / 16.05.2012

Expiration Date:Unlimited

The owner of the registration certificate:IRBITSK HFZ, OJSC IRBITSK HFZ, OJSC Russia

Manufacturer: & nbsp

IRBITSK HFZ, OJSC Russia

Information update date: & nbsp24.08.2017

Illustrated instructions

Instructions

Analgin (Analgin)