Analgin-Ultra - instructions for use, dose, side effects, contraindications

Excipients: potato starch, microcrystalline cellulose, silicon dioxide colloid (aerosil), hypromellose (hydroxypropylmethylcellulose), crospovidone, magnesium stearate, talc; shell: Opadrai II (polyvinyl alcohol, macrogol, talc, titanium dioxide, pigments (aluminum oxides).

Description:

The tablets covered with a film membrane of pink color, biconvex, oblong with rounded ends, with a risk.

Pharmacotherapeutic group:Analgesic non-narcotic remedy

ATX: & nbsp

Metamizol sodium

Pharmacodynamics:

Analgin Ultra refers to non-narcotic agents, derivatives of pyrazolone. It has analgesic, antipyretic and weak anti-inflammatory action.

Pharmacodynamics

Analgin unselectively blocks cyclooxygenase and reduces the formation of prostaglandins from arachidonic acid, prevents painful extra- and proprioceptive impulses. Analgin-Ultra has a weakly expressed anti-inflammatory effect, which causes a small effect on water-salt metabolism (sodium and water retention) and gastrointestinal mucosa. Has spasmolytic effect on the smooth muscles of the urinary and biliary tract.

The action develops 20-40 minutes after ingestion.

Pharmacokinetics:

Good and quickly absorbed from the digestive tract, which provides a rapid development of the clinical effect. When taken in therapeutic doses penetrates into the mother's milk. The maximum concentration in the plasma is achieved after 1-1,5 h after ingestion. In the intestinal wall, it hydrolyses to form an active metabolite, 4-methyl-amino-antipyrine, which in turn is metabolized to 4-formyl-amino-antipyrine and other metabolites.The level of binding of the active metabolite with proteins is 50-60%. Excretion of metabolites passes through the kidneys. In addition, metabolites are excreted in breast milk.

Indications:

Pain syndrome of mild and moderate severity: headache of various etiologies, neuralgia, myalgia, arthralgia, trauma, radiculitis, myositis, algodismenorea. Analgin Ultra is used for pain of visceral origin (with renal, hepatic, intestinal colic) in combination with antispasmodics.

To reduce pain after surgical and diagnostic interventions. Feverish syndrome on the background of infectious and inflammatory diseases.

Contraindications:

Hypersensitivity to pyrazolone derivatives, hematopoietic suppression (agranulocytosis, neutropenia), hepatic and / or renal insufficiency, hereditary hemolytic anemia associated with glucose-6-phosphate dehydrogenase deficiency and other anemia, asthma induced by acetylsalicylic acid, salicylates and other non-steroidal anti-inflammatory drugs , leukopenia, pregnancy (especially in the first trimester and in the last 6 weeks), lactation period, children under 15 years.

Carefully:

With kidney diseases (pyelonephritis, glomerulonephritis - including in the anamnesis), with moderately severe violations of the liver and kidneys, bronchial asthma, predisposition to the development of arterial hypotension, long-term alcohol abuse.

Pregnancy and lactation:

Dosing and Administration:

Inside, after eating, adults are prescribed 500 mg 2-3 times a day, the maximum single dose is 1000 mg, daily - 3000 mg. Duration of admission without consulting a doctor is no more than 5 days as an anesthetic and no more than 3 days as an antipyretic.

Side effects:

From the urinary system: a violation of kidney function, oliguria, anuria, proteinuria, interstitial nephritis, urine staining in red.

Allergic reactions: urticaria (including conjunctiva and mucous membranes of the nasopharynx), angioedema, in rare cases - malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), bronchospastic syndrome, anaphylactic shock.

On the part of the organs of hematopoiesis: agranulocytosis, leukopenia, thrombocytopenia.

Other: lowering blood pressure.

Overdose:

Symptoms: nausea, vomiting, gastralgia, oliguria, hypothermia, lowering of arterial pressure, tachycardia, dyspnea, tinnitus, drowsiness, delirium, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, acute renal and / or hepatic insufficiency, convulsions, respiratory muscle paralysis.

Treatment: gastric lavage, saline laxatives, Activated carbon, carrying out forced diuresis, hemodialysis, with the development of convulsive syndrome - intravenous diazepam and high-speed barbiturates.

Interaction:

Simultaneous administration with other non-narcotic analgesics, tricyclic antidepressants, contraceptive hormonal drugs and allopurinol may lead to increased toxicity; sedative and anxiolytic drugs enhance the analgesic effect of metamizole sodium. Metamizol sodium enhances the effects of alcohol; simultaneous application with chlorpromazine or phenothiazine may lead to the development of severe hyperthermia.Radiopaque drugs, colloidal blood substitutes and penicillin should not be used during treatment with metamizole sodium.

With the simultaneous administration of cyclosporine, the concentration of the latter in the blood decreases. Metamizol sodium, displacing out of association with protein oral hypoglycemic drugs, indirect anticoagulants, corticosteroids and indomethacin, increases their activity. Phenylbutazone, barbiturates and other inducers of microsomal liver oxidation, while concomitantly reducing the effectiveness of metamizole sodium. The effect is enhanced codeine, histamine H2-blockers and propanolol.

Special instructions:

When treating patients receiving cytotoxic drugs, taking Analgin-ULTRA should be done only under the supervision of a doctor.

Patients with atopic bronchial asthma and pollinosis have an increased risk of developing allergic reactions. Against the background of taking Analgin-ULTRA, the development of agranulocytosis is possible, therefore, if an unmotivated rise in temperature, chills, sore throats, difficulty swallowing, stomatitis, as well as the development of the phenomena of vaginitis or proctitis, immediate withdrawal of the drug is necessary.With prolonged use, it is necessary to monitor the picture of peripheral blood.

It is inadmissible to use to relieve acute pain in the abdomen (until the cause is clarified).

Form release / dosage:

Tablets, film-coated 500 mg.

Packaging:

5, 10, 12, 15, 20 or 30 tablets in a contour acrylic package of polyvinylchloride film EP-73 in accordance with GOST 25250-88 or imported, approved for use M3 RF, and aluminum foil printed according to TU 48-21-270 -94 or in accordance with GOST 745- 2003 or imported, approved for use M3 RF.

For 1, 2, 5, 10 or 14 contour squares, together with the instructions for use, are placed in a pack of cardboard in accordance with GOST 7933-89.

Storage conditions:

In a dry, protected from light at a temperature of no higher than 25 ° C.

In a place inaccessible to children.

Shelf life:

5 years. Do not use after the date shown on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-002208/07

Date of registration:15.08.2007 / 16.10.2015

Expiration Date:Unlimited

The owner of the registration certificate:OBOLENSKOE PHARMACEUTICAL ENTERPRISE, CJSC OBOLENSKOE PHARMACEUTICAL ENTERPRISE, CJSC Russia

Manufacturer: & nbsp

OBOLENSKOE PHARMACEUTICAL ENTERPRISE, CJSC Russia

Representation: & nbspOBOLENSKOE PHARMACEUTICAL ENTERPRISE, CJSCOBOLENSKOE PHARMACEUTICAL ENTERPRISE, CJSCRussia

Information update date: & nbsp27.08.2017

Illustrated instructions

Instructions

Analgin-Ultra (Analgin-Ultra)