Analgin - instructions for use, dose, side effects, contraindications

Analgin unselectively blocks cyclooxygenase and reduces the formation of prostaglandins from arachidonic acid, prevents painful extra- and proprioceptive impulses.Analgin has a weakly expressed anti-inflammatory effect, which causes a small effect on water-salt metabolism (sodium and water retention) and gastrointestinal mucosa. Has spasmolytic effect on the smooth muscles of the urinary and biliary tract.

The action develops 20-40 minutes after ingestion.

Pharmacokinetics:

Good and quickly absorbed in the digestive tract, which provides a rapid development of the clinical effect. When taken in therapeutic doses penetrates into the mother's milk. The maximum concentration in the plasma is achieved after 1-1,5 h after ingestion.

In the intestinal wall, it hydrolyses to form an active metabolite, 4-methyl-amino-antipyrine, which in turn is metabolized to 4-formyl-amino-antipyrine and other metabolites. The level of binding of the active metabolite with proteins is 50-60%. Excretion of metabolites passes through the kidneys. In addition, metabolites are excreted in breast milk.

Indications:

Feverish syndrome on the background of infectious and inflammatory diseases, headache of different genesis, pain syndrome of mild and moderate severity: neuralgia, myalgia, arthralgia, biliary colic, intestinal colic,renal colic, trauma, sciatica, myositis, postoperative pain syndrome, algodismenorea.

Contraindications:

Hypersensitivity, oppression of hematopoiesis (agranulocytosis, neutropenia), hepatic and / or renal failure, hereditary hemolytic anemia associated with deficiency of glucose-6-phosphate dehydrogenase and other types of anemia, intolerance to acetylsalicylic acid, asthma caused by acetylsalicylic acid, nasal polyps, anemia, leukopenia, pregnancy (especially in the first trimester and in the last 6 weeks), lactation period, children's age up to 8 years (for this dosage form).

Carefully:

With kidney diseases (pyelonephritis, glomerulonephritis - including in the anamnesis), with moderately severe violations of the liver and kidneys, bronchial asthma, predisposition to the development of arterial hypotension, long-term alcohol abuse.

Pregnancy and lactation:Contraindicated.

Dosing and Administration:

Inside, after eating, adults and children over 14 years are prescribed 250-500 mg 2-3 times a day, the maximum single dose is 1000 mg, daily - 3000 mg.

Children aged 8-14 years are prescribed 250 mg (1/2 tablet) 2-3 times a day.

Duration of admission without consulting a doctor is no more than 5 days.

Side effects:

From the urinary system: a violation of kidney function, oliguria, anuria, proteinuria, interstitial nephritis, urine staining in red.

Allergic reactions: urticaria (including conjunctiva and mucous membranes of the nasopharynx), angioedema, in rare cases - malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), bronchospastic syndrome, anaphylactic shock.

On the part of the organs of hematopoiesis: agranulocytosis, leukopenia, thrombocytopenia.

Other: lowering blood pressure.

Overdose:

Symptoms: nausea, vomiting, gastralgia, oliguria, hypothermia, lowering of arterial pressure, tachycardia, dyspnea, tinnitus, drowsiness, delirium, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, acute renal and / or hepatic insufficiency, convulsions, respiratory muscle paralysis.

Treatment: gastric lavage, saline laxatives, Activated carbon, carrying out forced diuresis, hemodialysis, with the development of convulsive syndrome - intravenous diazepam and high-speed barbiturates.

Interaction:

Simultaneous administration with other non-narcotic analgesics, tricyclic antidepressants, contraceptive hormonal drugs and allopurinol may lead to increased toxicity; sedative and anxiolytic drugs enhance the analgesic effect of metamizole sodium.

Metamizole sodium enhances the effects of alcohol; simultaneous application with chlorpromazine or phenothiazine may lead to the development of severe hyperthermia. Radiopaque drugs, colloidal blood substitutes and penicillin should not be used during treatment with metamizole sodium.

With the simultaneous administration of cyclosporine, the concentration of the latter in the blood decreases. Metamizol sodium, displacing out of association with protein oral hypoglycemic drugs, indirect anticoagulants, corticosteroids and indomethacin, increases their activity. Phenylbutazone, barbiturates and other inducers of microsomal liver oxidation, while concomitantly reducing the effectiveness of metamizole sodium.

Special instructions:

When treating patients receiving cytotoxic drugs, taking Analgin should be done only under the supervision of a doctor.

Patients with atopic bronchial asthma and pollinosis have an increased risk of developing allergic reactions. Against the background of taking Analgin, agranulocytosis may develop, so that if there is an unmotivated rise in temperature, chills, sore throats, difficulty swallowing, stomatitis, as well as the development of the phenomena of vaginitis or proctitis, immediate withdrawal of the drug is necessary. With prolonged use, it is necessary to monitor the picture of peripheral blood.

It is inadmissible to use to relieve acute pain in the abdomen (until the cause is clarified).

Form release / dosage:

Tablets of 500 mg.

Packaging:For 10 pieces in a contiguous cellless or in a contour mesh package. 2 contour mesh packs together with instructions for use are placed in a pack of cardboard. Contour packs with an equal number of instructions are placed in a group package.

Storage conditions:In a dry place, protected from light, out of reach of children, at a temperature not exceeding +25 ° С.

Shelf life:

5 years. Do not use after the date shown on the package.

Terms of leave from pharmacies:Without recipe

Registration number:P N000451 / 01

Date of registration:23.01.2008 / 10.11.2014

Expiration Date:Unlimited

The owner of the registration certificate:TATHIMFARMPREPARATY, JSC TATHIMFARMPREPARATY, JSC Russia

Manufacturer: & nbsp

TATHIMFARMPREPARATY, JSC Russia

Representation: & nbspTATHIMFARM PREPARATIONS OJSC TATHIMFARM PREPARATIONS OJSC Russia

Information update date: & nbsp25.08.2017

Illustrated instructions

Instructions

Analgin (Analgin)