Analgin - instructions for use, dose, side effects, contraindications

An analgesic non-narcotic agent, a derivative of pyrazolone. Analgin unselectively blocks cycloxeginase and reduces the formation of prostaglandin from arachidonic acid.Prevents painful extra- and proprioceptive pulses along the Gaull and Burdach beams, raises the threshold of excitability of thalamic pain centers sensitivity, increases heat transfer. A distinctive feature is the slight severity of the anti-inflammatory effect, which causes a weak effect on water-salt metabolism (delay Na+ and water) and the mucous membrane of the gastrointestinal tract. Possesses anesthetizing, antipyretic and some spasmolytic action (for the smooth muscles of the urinary and biliary tracts).

Pharmacokinetics:

After intravenous administration, the elimination half-life is 14 minutes. Approximately 96% is excreted in the urine in the form of metabolites. The association of the active metabolite with proteins is 50-60%. Metabolised in the liver, excreted by the kidneys. In therapeutic doses penetrates into breast milk.

Indications:Pain syndrome of mild to moderate severity of various originpain, migraine, toothache, neuralgia, myalgia, dysmenorrhea.
Pain of visceral origin - in combination with antispasmodic agents for renal, intestinal and biliary colic.
To reduce pain after surgical and diagnostic interventions, injuries, burns, decompression sickness.

Feverish conditions with infectious and inflammatory diseases, insect bites, posttransfusion complications. The expediency of using the drug is decided in each case, depending on the severity, nature and tolerability of the fever.

Contraindications:

Hypersensitivity to pyrozolones, hematopoietic suppression (agranulocytosis, neutropenia), hepatic and / or renal insufficiency, hereditary hemolytic anemia associated with deficiency of glucose-6-phosphate dehydrogenase and other anemia, aspirin asthma, leukopenia, pregnancy (especially in the first trimester and in the last 6 weeks). lactation period, children in the first three months of life, with a body weight of less than 5 kg.

It is inadmissible to use to relieve acute pain in the abdomen (until the cause is clarified).

Carefully:

With caution: pregnancy (especially in the first trimester and in the last 6 weeks), kidney disease (pyelonephritis, glomerulonephritis - including in the anamnesis), prolonged abuse of ethanol, intravenous administration to patients with systolic blood pressure below 100 mmHg.or with instability of blood circulation (for example, against a background of myocardial infarction, multiple trauma, starting shock).

Pregnancy and lactation:Contraindicated

Dosing and Administration:

The drug is administered intramuscularly or intravenously (with severe pain) 1 to 2 ml of 500 mg / ml solution 2-3 times a day, but not more than 2 g per day. The maximum single dose is 1g. daily-2d.

Children are administered at the rate of 0.1-0.2 ml of 500 mg / ml solution for every 10 kg of the child's body weight 2-3 times a day. Children under 1 year with a body weight of more than 5 kg of the drug is administered only intramuscularly, the course is not more than 3 days.

The injected solution must have a body temperature. Doses of more than 1 g should be administered internally, it is necessary to have conditions for antishock therapy.

The most frequent cause of a sharp decrease in blood pressure is too high a rate of administration, and therefore intravenous administration should be slow (at a rate of not more than 1 ml / min), in the patient's lying position, under the control of blood pressure, heart rate and respiration.

With prolonged (more than a week) application of the drug, control of the picture of peripheral blood and the functional state of the liver is necessary.

Side effects:

In therapeutic doses, the drug is usually well tolerated.

Possible allergic reactions, agranulocytosis, leukopenia, thrombocytopenia, urticaria, Quincke's edema, rarely anaphylactic shock, transient renal dysfunction: oliguria, anuria, proteinuria, interstitial nephritis, urticaria, urticaria rash on conjunctiva and mucous membranes of the nasopharynx; in very rare cases - Stevens-Johnson syndrome, Lyell's syndrome, bronchospastic syndrome.

With intramuscular injection, infiltrates are possible at the site of administration.

From the urinary system: staining the urine in red.

Overdose:

Symptoms: nausea, vomiting, gastralgia, oliguria, hypothermia, lowering blood pressure, tachycardia, dyspnea, tinnitus, drowsiness, delirium, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, acute renal and / or hepatic insufficiency, seizures, respiratory muscle paralysis .

Treatment: gastric lavage, saline laxatives, Activated carbon; carrying out forced diuresis, hemodialysis, with the development of convulsive syndrome - intravenous diazepam and high-speed barbiturates.

Interaction:

Because of the high likelihood of developing pharmaceutical incompatibility, you should not mix it with other drugs in the same syringe.

Enhances the effects of ethanol.

Radiopaque drugs, colloidal blood substitutes and penicillin should not be used during treatment with metamizole.

With the simultaneous administration of cyclosporine, the concentration of the latter in the blood decreases.

Metamizole, displacing from the bond with protein oral hypoglycemic drugs, indirect anticoagulants, glucocortosteroids and indomethacin, increases their activity. Phenylbutazone, barbiturates and other hepatoinductors with simultaneous administration decrease the effectiveness of metamizole.

Simultaneous appointment with other non-narcotic analgesics, tricyclic antidepressants, contraceptive hormonal drugs and allopurinol may lead to increased toxicity.

Sedative and anxiolytic drugs (tranquilizers) increase the analgesic effect of metamizole.

Thiamazole and cytostatics increase the risk of developing leukopenia.

The effect is enhanced codeine, H2-histamine receptor blockers and propranolol (slows inactivation).

Myelotoxic drugs increase the manifestation of hematotoxicity of the drug. Simultaneous use of analgin with other non-narcotic analgesics can lead to mutual enhancement of toxic effects. Tricyclic antidepressants and oral contraceptives disrupt the metabolism of analgin in the liver and increase its toxicity. Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the action of analgin. Simultaneous use of analgin with cyclosporine reduces the level of the latter in the blood. Sedatives and tranquilizers increase the analgesic effect of analgin.

The effect is enhanced by simultaneous application with codeine, histamine H2 blockers and propranolone.

Because of the high likelihood of pharmaceutical incompatibility, you should not mix it with other drugs in the same syringe.

Special instructions:

When treating children under 5 years and patients receiving cytotoxic drugs, metamizole sodium intake should be done only under medical supervision.

Intolerance is very rare,however, the threat of developing anaphylactic shock after intravenous administration of the drug is relatively higher than after taking the drug inside. Patients with atopic bronchial asthma and pollinosis have an increased risk of developing allergic reactions.

Against the background of taking metamizole sodium, the development of agranulocytosis is possible, therefore, if an unmotivated rise in temperature, chills, sore throats, difficulty swallowing, stomatitis, and the development of the phenomena of vaginitis or proctitis, immediate withdrawal of the drug is necessary. With prolonged use, it is necessary to monitor the picture of peripheral blood.

It is inadmissible to use to relieve acute pain in the abdomen (until the cause is clarified).

For intramuscular injection, a long needle should be used.

It is possible to stain urine in red by excretion of the metabolite (it has no value).

Form release / dosage:Solution for intravenous and intramuscular injection 500 mg / ml.

Packaging:

2 ml of the drug in dark ampoules glass with a break point.

10 ampoules are placed in the contour cell pack of film polyvinyl chloride. 1 contour cell packing together with instructure of the application place in a pack of cardboard.

Storage conditions:

List B. In a place protected from light and inaccessible to children at a temperature of no higher than 25 ° C.

Shelf life:

3 years. Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LS-002527

Date of registration:22.01.2014

The owner of the registration certificate:ALVILS, LTD. ALVILS, LTD. Russia

Manufacturer: & nbsp

ALVILS, LTD. Russia

Representation: & nbspAlvils, OOOAlvils, OOO

Information update date: & nbsp27.08.2016

Illustrated instructions

Instructions

Analgin (Analgin)