Analgin - instructions for use, dose, side effects, contraindications

Composition:One suppository contains: active substance - metamizole sodium (analgin) - 0.1 g and 0.25 g (in terms of dry matter); bases for suppositories: fat solid (vitepsol (brands H 15, W 35), supposyr (brands NA 15, NAS 50)) - a sufficient amount to obtain a suppository with a mass of 1.25 g.

Description:Suppositories white, white with yellowish or white with a creamy shade of color, torpedo-shaped.

Pharmacotherapeutic group:Analgesic non-narcotic remedy

ATX: & nbsp

Metamizol sodium

Pharmacodynamics:

The pyrazolone derivative, according to the mechanism of actiondoes not differ significantly from non-steroidal anti-inflammatory drugs (nonselectively blocks cyclooxygenase and reduces the formation of prostaglandins from arachidonic acid).

It prevents painful extra- and proprioceptive pulses along the Gaull and Burdach beams, raises the threshold of excitability of thalamic centers of pain sensitivity, increases heat transfer.

The drug has analgesic, antipyretic and some spasmolytic effects (in relation to the smooth muscles of the urinary and biliary tract).

The action develops 20-40 minutes after application and reaches a maximum after 2 hours. A distinctive feature of metamizole sodium is a slight expression of anti-inflammatory effect, as well as the lack of influence on water-salt metabolism and gastric mucosa.

Pharmacokinetics:

Bioavailability is 54%. Metabolized in the liver, excreted by the kidneys.

Unchanged metamizol sodium in the blood is not determined. The association of metabolites with proteins - 50-60%

Indications:

Feverish syndrome in acute respiratory infections, childhood infectious and other infectious and inflammatory diseases.Pain syndrome (mild to moderate), including: headache, toothache, neuralgia, myalgia, arthralgia, biliary colic, renal colic, trauma, burns, postoperative pain syndrome, algodismenorea.

Contraindications:

Hypersensitivity. Bronchial asthma induced by the use of acetylsalicylic acid, salicylates or other non-steroidal anti-inflammatory drugs. Inhibition of hematopoiesis (agranulocytosis, cytostatic or infectious neutropenia).

Anemia, leukopenia, liver and / or renal failure, hereditary hemolytic anemia associated with a deficiency of glucose-6-phosphate dehydrogenase. Age to 3 years.

Carefully:

Diseases of the kidneys (pyelonephritis, glomerulonephritis - including in the anamnesis).

Pregnancy and lactation:

The drug is contraindicated in pregnancy and during breastfeeding.

Dosing and Administration:

Rectally. After cleansing enema or spontaneous emptying of the intestine, the suppositories are released from the contour pack (previously cut with scissors) and injected into the rectum.

The average daily dose is 10 mg / kg body weight in 2-3 doses.

Suppositories of 100 mg are recommended for use in children:

from 3 years to 7 years - 1-2 suppository 2 times a day.

Suppositories of 250 mg are recommended for use in children:

from 7 to 14 years - 1-2 suppository 2 times a day.

After the introduction of the suppository, the child should be lying in the lying position for 20-30 minutes. Duration of treatment is no more than 3 days. Further treatment with the drug on the recommendation of a doctor.

Side effects:

Allergic reactions: urticaria, angioedema, bronchospastic syndrome, anaphylactic shock. In rare cases - malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome).

From the urinary system: a violation of kidney function, oliguria, anuria, proteinuria, interstitial nephritis, urine staining in red.

On the part of the organs of hematopoiesis: agranulocytosis, leukopenia, thrombocytopenia.

Other: lowering blood pressure.

Overdose:

Symptoms: nausea, vomiting, pain in the stomach, oliguria, hypothermia, lowering blood pressure,tachycardia, dyspnea, tinnitus, drowsiness, delirium, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, acute renal and / or hepatic insufficiency, convulsions, paralysis of the respiratory musculature.

Treatment: saline laxatives, conducting forced diuresis, hemodialysis, with the development of convulsive syndrome - intravenous diazepam and high-speed barbiturates. There is no specific antidote.

Interaction:

Simultaneous use with chlorpromazine or other phenothiazine derivatives can lead to the development of severe hyperthermia.

Radiopaque drugs, colloidal blood substitutes and penicillin should not be used during treatment with metamizole.

With the simultaneous use of cyclosporine, the concentration of the latter in the blood decreases. Pharmaceutical activity of drugs that metamizol sodium displaces out of association with the protein (oral hypoglycemic drugs, indirect anticoagulants, glucocorticoids and indomethacin), is increasing.

Phenylbutazone, barbiturates and other inducers of microsomal oxidation in the liver with simultaneous use reduce the effectiveness of metamizole sodium.

Simultaneous use with other non-narcotic analgesics, tricyclic antidepressants, contraceptive hormonal drugs and allopurinol may lead to an increase in the toxicity of metamizole sodium.

Sedative and anxiolytic drugs enhance the analgesic effect of metamizole sodium.

Thiamazole and cytostatics increase the risk of developing leukopenia.

The effect is enhanced codeine, H2-histamine receptor blockers and propranolol (slows down inactivation)

Metamizole sodium enhances the effects of ethanol.

Drugs that have myelotoxicity, with simultaneous use, increase the hematotoxicity of the drug.

Special instructions:

Do not use concomitantly with Preparations containing metamizol sodium (Analgin) and non-steroidal anti-inflammatory drugs. When treating children 3, -5 years and children receiving cytotoxic drugs, metamizole sodium intake should be performed only under the supervision of a doctor.

Intolerance is very rare. In children with atopic bronchial asthma and pollinosis, there is an increased risk of allergic reactions.

Against the background of taking metamizole sodium, the development of agranulocytosis is possible, therefore, if an unmotivated rise in temperature, chills, sore throats, difficulty swallowing, stomatitis, erosive-ulcerative lesions of the oral cavity, vaginitis or proctitis is required, immediate withdrawal of the drug is necessary. With prolonged use, it is necessary to monitor the picture of peripheral blood.

It is inadmissible to use to relieve acute pain in the abdomen (until the cause is clarified).

It is possible to stain the urine in red.

Form release / dosage:

Suppositories rectal for children of 100 mg and 250 mg.

Packaging:

There are 5 suppositories in a contiguous cell package. Two contour mesh packs, along with instructions for medical use of the drug, are placed in a pack of cardboard.

Storage conditions:

Store in a dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:2 of the year. Do not use the drug after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:P N000443 / 01

Date of registration:05.03.2010

Expiration Date:Unlimited

The owner of the registration certificate:NIZHFARM, JSC NIZHFARM, JSC Russia

Manufacturer: & nbsp

NIZHFARM, JSC Russia

Representation: & nbspNizhpharm, JSCNizhpharm, JSCRussia

Information update date: & nbsp25.08.2017

Illustrated instructions

Instructions

Analgin (Analgin)