Simultaneous use of Analgin with other non-narcotic analgesics may result to mutual enhancement of toxic effects.
Tricyclic antidepressants, oral contraceptives and allopuripol disrupt the metabolism of metamizole in the liver and increase its toxicity. Barbiturates and phenylbutazone weaken the action of analgin.
Analgin increases the effects of alcohol-containing beverages.
Radiocontrast agents, colloidal blood substitutes and penicillin should not be used during metamizole treatment.
Metamizole, displacing from the connection with protein oral hypoglycemic drugs, indirect anticoagulants, glucocorticosteroids and indomethadine, increases their activity.
Simultaneous use of Analgin with cyclosporine reduces the level of the latter in the blood. Thiamazole and sarcolysin increase the risk of developing leukopenia. When used simultaneously with drugs that have a myelotoxic effect, the manifestation of hematotoxicity of analgin increases.
The effect is enhanced codeine, propranolol (slows inactivation).
Sedatives and tranquilizers increase the analgesic effect of analgin.
Because of the high likelihood of pharmaceutical incompatibility, metamizole should not be mixed with other drugs in the same syringe.