Analgin - instructions for use, dose, side effects, contraindications

Active substance: Analgin (metamizol sodium) - 500 mg, Excipients: potato starch - 31.4 mg, povidone (low molecular weight polyvinylpyrrolidone) 3.6 mg, sucrose (sugar refined) 5 mg, talc 5 mg, calcium stearate 5 mg.

Description:Tablets are white or white with a yellowish tint of color, flat-cylindrical with a facet and a risk on one side.

Pharmacotherapeutic group:Analgesic non-narcotic remedy.

ATX: & nbsp

Metamizol sodium

Pharmacodynamics:

An analgesic non-narcotic agent, a derivative of pyrazolone, nonselectively blocks cyclooxygenase and reduces the formation of prostaglandins from arachidonic acid.It prevents painful extra- and proprioceptive pulses along the Gaull and Burdach beams, raises the threshold of excitability of thalamic centers of pain sensitivity, increases heat transfer.

A distinctive feature is the slight severity of the anti-inflammatory effect, which causes a weak effect on water-salt metabolism (sodium and water retention) and the mucous membrane of the gastrointestinal tract. Has analgesic, antipyretic and some spasmolytic (with respect to the smooth muscles of the urinary and bile ducts) action.

The effect develops 20-40 minutes after ingestion and reaches a maximum after 2 hours.

Pharmacokinetics:

Good and quickly absorbed into the gastrointestinal tract. In the intestinal wall it hydrolyzes with the formation of an active metabolite. Unchanged metamizol sodium in the blood is absent (only after intravenous administration, its insignificant concentration is found in to plasma). The association of the active metabolite with plasma proteins is 50-60%. Metabolized in the liver, excreted by the kidneys. In therapeutic concentrations penetrates into breast milk.

Indications:

Feverish syndrome (infectious and inflammatory diseases, insect bites - mosquitoes, bees, gadflies, etc.);

Pain syndrome (mild to moderate): incl. neuralgia, myalgia, arthralgia, biliary colic, intestinal colic, renal colic, trauma, burns, postoperative pain syndrome, headache, toothache, algodismenorea.

Contraindications:

Hypersensitivity, oppression of hematopoiesis (agranulocytosis, cytostatic or infectious neutropenia), hepatic and / or renal failure, hereditary hemolytic anemia associated with deficiency of glucose-6-phosphate dehydrogenase, complete or incomplete combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (including anamnesis), leukopenia, pregnancy, lactation, children under 3 years old.

Carefully:should take the drug in diseases of the kidneys (pyelonephritis, glomerulonephritis, including in the history), alcoholism.

Pregnancy and lactation:Application during pregnancy and during lactation is contraindicated.

Dosing and Administration:Inside, after eating, adults and children over 14 years of age are prescribed 250-500 mg 2-3 times a day. The maximum single dose is 1000 mg, the daily dose is 3000 mg. Children are prescribed 5-10 mg / kg body weight 3-4 times a day for not more than 3 days (previously crushed tablet).

Do not use (without consulting a doctor) more than 3 days when prescribed as an antipyretic agent and more than 5 days - when prescribed as an anesthetic.

Side effects:

From the urinary system: renal dysfunction, oliguria, anuria, proteinuria, interstitial nephritis, urine staining in red.

Allergic reactions: urticaria (including conjunctiva and mucous membranes of the nasopharynx), angioedema, in rare cases - malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), bronchospastic syndrome, anaphylactic shock.

From the hematopoiesis: agranulocytosis, leukopenia, thrombocytopenia.

Other: lowering of blood pressure.

Overdose:

Symptoms: nausea, vomiting, gastralgia, oliguria, hypothermia, lowering blood pressure,tachycardia, dyspnea, tinnitus, drowsiness, delirium, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, acute renal and / or hepatic insufficiency, convulsions, paralysis of the respiratory musculature.

Treatment: gastric lavage, saline laxatives, Activated carbon, conducting forced diuresis, hemodialysis, with the development convulsive syndrome - intravenous diazepam and high-speed barbiturates.

Interaction:

Simultaneous use with other non-narcotic analgesics, tricyclic antidepressants, contraceptive hormonal drugs and allopurinol may lead to increased toxicity; sedative and anxiolytic drugs enhance the analgesic effect of metamizole sodium. Metamizol sodium enhances the effects of alcohol; simultaneous application with chlorpromazine or phenothiazine may lead to the development of severe hyperthermia. Radiopaque drugs, colloidal blood substitutes and penicillin should not be used during treatment with metamizole sodium.

With the simultaneous use of Analgin with cyclosporine, the concentration of the latter in the blood decreases. Metamizol sodium, displacing from the connection with plasma proteins, oral hypoglycemic drugs, indirect anticoagulants, corticosteroids and indomethacin, increases their activity. Phenylbutazone, barbiturates and other inducers of microsomal oxidation of the liver with simultaneous use reduce the effectiveness of metamizole sodium.

Thiamazole and cytostatics increase the risk of developing leukopenia.

The effect is enhanced codeine, H2-histamine receptor blockers and propranolol (slows inactivation).

Myelotoxic drugs increase manifestations hematotoxicity of the drug.

Special instructions:

When treating children under 5 years and patients receiving cytotoxic drugs, taking Analgin should be done only under the supervision of a doctor.

Patients with atopic bronchial asthma and pollinosis have an increased risk of developing allergic reactions. Against the background of taking Analgin, agranulocytosis may develop, so that if there is an unmotivated rise in temperature, chills, sore throats, difficulty swallowing, stomatitis,and also with the development of the phenomena of vaginitis or proctitis, immediate withdrawal of the drug is necessary. With prolonged use, it is necessary to monitor the picture of peripheral blood. It is inadmissible to use to relieve acute pain in the abdomen (until the cause is clarified).

It is possible that the urine is colored red by the release of a metabolite (it has no clinical significance).

Effect on the ability to drive transp. cf. and fur:

The adverse effect of the drug on the ability to drive and engage in other activities that require concentration and speed of psychomotor reactions were not reported.

Form release / dosage:Tablets of 500 mg.

Packaging:

10 tablets per contour cell packaging made of polyvinylchloride film and aluminum foil.

1-2 contour mesh packages together with instructions for use are placed in a pack of cardboard for consumer containers.

300 contour mesh packages with an equal number of instructions for use are placed in a group package.

Storage conditions:

In a dry, dark place at a temperature of 2 to 25 ° C.

Keep out of the reach of children.

Shelf life:

4 years.Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:P N001074 / 01

Date of registration:27.02.2012

The owner of the registration certificate:MOSHIMFARM PREPARATES them. N.А.Semashko, OJSC MOSHIMFARM PREPARATES them. N.А.Semashko, OJSC Russia

Manufacturer: & nbsp

MOSHIMFARM PREPARATES them. NA Semashko OJSC Russia

Representation: & nbspMOSHIMFARM PREPARATES them. NA Semashko OJSC MOSHIMFARM PREPARATES them. NA Semashko OJSC Russia

Information update date: & nbsp21.08.2016

Illustrated instructions

Instructions

Analgin (Analgin)