Analgin - instructions for use, dose, side effects, contraindications

An analgesic non-narcotic agent, a derivative of pyrazolone, nonselectively blocks cyclooxygenase and reduces the formation of prostaglandins from arachidonic acid.

Prevents painful extra- and proprioceptive impulses along the Golli and Burdach beams, raises the threshold of excitability of thalamic centers of pain sensitivity, increases heat transfer.

A distinctive feature is the slight severity of the anti-inflammatory effect, which causes a weak effect on water-salt metabolism (sodium and water retention) and the mucous membrane of the gastrointestinal tract. Has analgesic, antipyretic and some spasmolytic (with respect to the smooth muscles of the urinary and bile ducts) action.

The effect develops 20-40 minutes after ingestion and reaches a maximum after 2 hours.

Pharmacokinetics:

Good and quickly absorbed into the gastrointestinal tract. In the intestinal wall it hydrolyzes with the formation of an active metabolite. Unchanged metamizole sodium in the blood is absent. The association of the active metabolite with proteins - 50-60 %. Metabolized in the liver, excreted by the kidneys. In therapeutic concentrations penetrates into breast milk.

Indications:

Feverish syndrome (infectious and inflammatory diseases, insect bites - mosquitoes, bees, gadflies and other post-transfusion complications).

Pain syndrome (mild to moderate): including neuralgia, myalgia, arthralgia, biliary colic, intestinal colic, renal colic, trauma, burns, decompression sickness, shingles, orchitis, sciatica, myositis, postoperative pain syndrome, headache, toothache, algodismenorea.

Contraindications:

Hypersensitivity, oppression of hematopoiesis (agranulocytosis, cytostatic or infectious neutropenia), hepatic and / or renal failure, hereditary hemolytic anemia associated with deficiency of glucose-6-phosphate dehydrogenase, complete or incomplete combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (including history), anemia, leukopenia, pregnancy, lactation.

Carefully:

Infant age to 3 months, kidney disease (pyelonephritis, glomerulonephritis - including in history), alcoholism.

Pregnancy and lactation:Contraindicated.

Dosing and Administration:

Inside, 250-500 mg 2-3 times a day, the maximum single dose - 1 g, daily - 3 g.Single doses for children 8-14 years -250 mg, the frequency of reception 2-3 times a day.

Side effects:

From the urinary system: a violation of kidney function, oliguria, anuria, proteinuria, interstitial nephritis, urine staining in red.

Allergic reactions: urticaria (including conjunctiva and mucous membranes of the nasopharynx), angioedema, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), bronchospastic syndrome, anaphylactic shock.

On the part of the organs of hematopoiesis: agranulocytosis, leukopenia, thrombocytopenia.

Other: lowering of blood pressure

Overdose:

Symptoms: nausea, vomiting, gastralgia, oliguria, hypothermia, lowering of arterial pressure, tachycardia, dyspnea, tinnitus, drowsiness, delirium, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, acute renal and / or hepatic insufficiency, convulsions, respiratory muscle paralysis.

Treatment: gastric lavage, saline laxatives, Activated carbon; carrying out forced diuresis, hemodialysis,with the development of convulsive syndrome - intravenous diazepam and high-speed barbiturates.

Interaction:

Enhances the effects of ethanol.

Radiopaque drugs, colloidal blood substitutes and penicillin should not be used during treatment with metamizole sodium.

With the simultaneous use of cyclosporine, the concentration of the latter in the blood decreases.

Metamizole sodium, displacing from the connection with plasma proteins, oral hypoglycemic drugs, indirect anticoagulants, glucocorticosteroids and indomethacin, increases their activity.

Phenylbutazone, barbiturates and other inducers of microsomal liver enzymes with simultaneous use reduce the effectiveness of metamizole sodium. Simultaneous use with other non-narcotic analgesics, tricyclic antidepressants, contraceptive hormonal drugs and allopurinol may lead to increased toxicity. Sedative and anxiolytic drugs (tranquilizers) increase the analgesic effect of metamizole sodium.

Thiamazole and cytostatics increase the risk of developing leukopenia.

The effect is enhanced codeine, H2-histamine receptor blockers and propranolol (slows inactivation).

Myelotoxic drugs increase the manifestation of hematotoxicity of the drug.

Special instructions:

When treating children under 5 years and patients receiving cytotoxic drugs, metamizole sodium intake should be done only under the supervision of a doctor. Patients with atopic bronchial asthma and pollinosis have an increased risk of developing allergic reactions.

Against the background of taking metamizole sodium, agranulocytosis may develop, in connection with which, when an unmotivated rise in temperature, chills, sore throats, difficulty swallowing, stomatitis, as well as in the development of phenomena of vaginitis or proctitis you need immediate withdrawal of the drug. With prolonged use, it is necessary to monitor the picture of peripheral blood.

It is inadmissible to use to relieve acute pain in the abdomen (until the cause is clarified). It is possible to stain urine in red by excretion of the metabolite (it has no value).

Form release / dosage:

Tablets of 500 mg.

Packaging:

For 10 tablets in a contour mesh package made of a polyvinylchloride film and aluminum foil or 10 tablets incontour non-cellular package of paper packaging with polyethylene coating.

For 2 or 3 contour mesh packages together with the instruction for use are placed in a pack of cardboard for consumer containers.

It is allowed to use contoured cell packs with an equal number of instructions for use in a carton box box.

Contour non-cellular packages with an equal number of instructions for use are placed in a carton box box.

Storage conditions:

In a dry, protected from light place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

5 years. Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LS-002585

Date of registration:29.12.2011

Expiration Date:Unlimited

The owner of the registration certificate:MARBIOFARM, OJSC MARBIOFARM, OJSC Russia

Manufacturer: & nbsp

MARBIOFARM, OJSC Russia

Information update date: & nbsp25.08.2017

Illustrated instructions

Instructions

Analgin (Analgin)