Analgin - instructions for use, dose, side effects, contraindications

Metamizole sodium - an analgesic non-narcotic agent, a derivative of pyrazolone, nonselectively blocks cyclooxygenase and reduces the formation of prostaglandins from arachidonic acid.

It prevents painful extra- and proprioceptive pulses along the Gaull and Burdach beams, raises the threshold of excitability of thalamic centers of pain sensitivity, increases heat transfer.

A distinctive feature is the insignificant severity of the anti-inflammatory effect, which causes a weak effect on water-salt metabolism (sodium and water retention) and the mucous membrane of the gastrointestinal tract. Has analgesic, antipyretic and some spasmolytic (with respect to the smooth muscles of the urinary and biliary ways) action. The effect develops 20-40 minutes after ingestion and reaches a maximum after 2 hours.

Pharmacokinetics:

The maximum concentration in the plasma is achieved after 1-1,5 h after ingestion. In the intestinal wall it hydrolyzes with the formation of an active metabolite. Unchanged metamizol sodium in the blood is absent. The association of the active metabolite with proteins is 50-60%. Excretion of metabolites passes through the kidneys. In addition, metabolites are excreted in breast milk.

Indications:

Feverish syndrome with infectious and inflammatory diseases, insect bites, posttransfusion complications.

Pain syndrome (mild to moderate): incl.neuralgia, myalgia, biliary colic, renal colic, postoperative pain syndrome, headache, toothache, algodismenorea.

Contraindications:

Hypersensitivity to the components of the drug, oppression of hematopoiesis (agranulocytosis, cytostatic or infectious neutropenia), hepatic and / or renal failure, hereditary hemolytic anemia associated with deficiency of glucose-6-phosphate dehydrogenase, leukopenia, pregnancy, lactation period, bronchial asthma induced by admission Acetylsalicylic acid, salicylates or other non-steroidal anti-inflammatory drugs, sugarase / isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption, anemia, age up to 8 years (for this dosage form).

Carefully:

Diseases of the kidneys (pyelonephritis, glomerulonephritis, including in the anamnesis), alcoholism, a predisposition to the development of arterial hypotension.

Pregnancy and lactation:

Dosing and Administration:

The maximum single dose is 1 g, the daily dose is 3 g. For children from 8 years to 14 years, the recommended dose is 250 mg, for children from 15 years and adults - 250-500 mg, the multiplicity Appointments -2-3 times a day. Duration admission without consultation with a doctor is not more than 5 days.

Side effects:

From the urinary system: a violation of kidney function, oliguria, anuria, proteinuria, interstitial nephritis, urine staining in red.

Allergic reactions: urticaria (including conjunctiva and mucous membranes of the nasopharynx) angioedema, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), bronchospastic syndrome, anaphylactic shock.

On the part of the organs of hematopoiesis: agranulocytosis, leukopenia, thrombocytopenia.

Other: lowering blood pressure.

Overdose:

Symptoms: nausea, vomiting, epigastric pain, oliguria, hypothermia, lowering of arterial pressure, tachycardia, dyspnea, tinnitus, drowsiness, delirium, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, acute renal and / or hepatic insufficiency, convulsions, paralysis respiratory musculature.

Treatment: gastric lavage, saline laxatives, activated; coal; carrying out forced diuresis, hemodialysis, with the development of convulsive syndrome - intravenous diazepam and high-speed barbiturates.

Interaction:

Radiopaque drugs, colloidal blood substitutes and penicillin should not be used during treatment with metamizole sodium. With the simultaneous use of cyclosporine, the concentration of the latter in the blood decreases.

Metamizole sodium, displacing from the connection with plasma proteins, oral hypoglycemic drugs, indirect anticoagulants, glucocorticosteroids and indomethacin, increases their activity.

Phenylbutazone, barbiturates and other inducers of microsomal liver enzymes with simultaneous use reduce the effectiveness of metamizole.

Simultaneous use with other non-narcotic analgesics, tricyclic antidepressants, contraceptive hormonal drugs and allopurinol may lead to increased toxicity.

Metamizole sodium enhances the effects of ethanol; simultaneous application with chlorpromazine or phenothiazine may lead to the development of severe hyperthermia.

Sedative and anxiolytic drugs (tranquilizers) increase the analgesic effect of metamizole sodium.

Thiamazole and cytostatics increase the risk of developing leukopenia.

The effect is enhanced codeine, H2-histamine receptor blockers and propranolol (slows inactivation).

Myelotoxic drugs increase the manifestation of hematotoxicity of the drug.

Special instructions:

In the treatment of patients receiving cytotoxic drugs, metamizole sodium should be administered only under medical supervision.

Patients with atopic bronchial asthma and pollinosis have an increased risk of developing allergic reactions.

Against the background of taking metamizole sodium, the development of agranulocytosis is possible, in connection with which, when an unmotivated rise in temperature, chills, sore throats, difficulty swallowing, stomatitis, as well as in the development of phenomena of vaginitis or proctitis, immediate withdrawal of the drug is necessary. With prolonged use, it is necessary to monitor the picture of peripheral blood. It is inadmissible to use to relieve acute pain in the abdomen (until the cause is clarified).

Form release / dosage:

Tablets 500 mg.

Packaging:

10 tablets per contour cell or cell-free packaging. One or two contour packs, together with the instruction for use, are placed in a pack of cardboard.

Contour non-jawed packages with equal instructions for use in group packaging are allowed.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:

5 years.

Do not use after expiry date.

Terms of leave from pharmacies:Without recipe

Registration number:P N001794 / 01

Date of registration:08.12.2008 / 11.09.2012

Expiration Date:Unlimited

The owner of the registration certificate:MOSCOW PHARMACEUTICAL FACTORY, CJSC MOSCOW PHARMACEUTICAL FACTORY, CJSC Russia

Manufacturer: & nbsp

MOSCOW PHARMACEUTICAL FACTORY, CJSC Russia

Representation: & nbspMOSCOW PHARMACEUTICAL FACTORY MOSCOW PHARMACEUTICAL FACTORY Russia

Information update date: & nbsp26.08.2017

Illustrated instructions

Instructions

Analgin (Analgin)