Analgin - instructions for use, dose, side effects, contraindications

White or white tablets with slightly yellowish hue of color, flat-faced, chamfered, with risk on one side and labeling "R" or without it - on the other.

Pharmacotherapeutic group:Analgesic non-narcotic remedy

ATX: & nbsp

Metamizol sodium

Pharmacodynamics:

Metamizole sodium - an analgesic non-narcotic agent, a derivative of pyrazolone, non-detensively blocks cyclooxygenase and reduces the formation of prostaglandins from arachidonic acid.

It prevents painful extra- and proprioceptive pulses along the Gaull and Burdach beams, raises the threshold of excitability of thalamic centers of pain sensitivity, increases heat transfer.

A distinctive feature is the insignificant severity of the anti-inflammatory effect, which causes a weak effect on water-salt metabolism (sodium and water retention) and the mucous membrane of the gastro-intestinal tract. Has analgesic, antipyretic and some spasmolytic (with respect to the smooth muscles of the urinary and biliary tract) action. The action develops in 20-40 minutes after taking the drug and reaches a maximum after 2 hours.

Pharmacokinetics:

The maximum concentration in the plasma is achieved after 1-1,5 h after ingestion. In the intestinal wall it hydrolyzes with the formation of an active metabolite. Unaltered metamizol sodium in the blood is absent. The association of the active metabolite with proteins is 50-60%. Excretion of metabolites passes through the kidneys. In addition, metabolites are excreted in breast milk.

Indications:

Feverish syndrome with infectious and inflammatory diseases, insect bites, posttransfusion complications.

Pain syndrome (mild to moderate): incl.neuralgia, myalgia, biliary colic, renal colic, postoperative pain syndrome, headache, toothache, algodismenorea.

Contraindications:

Hypersensitivity to the components of the drug, oppression of hematopoiesis (agranulocytosis, cytostatic or infectious neutropenia), hepatic and / or renal failure, hereditary hemolytic anemia associated with deficiency of glucose-6-phosphate dehydrogenase, sugarase / isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption, bronchial asthma induced by the use of acetylsalicylic acid, salicylates or other non-steroidal anti-inflammatory drugs, anemia, leukopenia, pregnancy, n Age of lactation, age to 8 years.

Carefully:

Diseases of the kidneys (pyelonephritis, glomerulonephritis, including in the anamnesis), alcoholism, a predisposition to the development of arterial hypotension.

Pregnancy and lactation:Contraindicated.

Dosing and Administration:

Inside. The maximum single dose is 1 g, the daily dose is 3 g. For children from 8 years to 14 years, the recommended dose is 250 mg, for children from 15 years and adults - 250-500 mg, the frequency of application is 2-3 times a day.Duration of admission without consulting a doctor is no more than 5 days.

Side effects:

From the urinary system: a violation of kidney function, oliguria, anuria, proteinuria, interstitial nephritis, urine staining in red.

Allergic reactions: urticaria (including conjunctiva and mucous membranes of the nasopharynx), angioedema, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), bronchospastic syndrome, anaphylactic shock.

On the part of the organs of hematopoiesis: agranulocytosis, leukopenia, thrombocytopenia.

Other: lowering blood pressure.

Overdose:

Symptoms: nausea, vomiting, epigastric pain, oliguria, hypothermia, lowering of arterial pressure, tachycardia, dyspnea, tinnitus, drowsiness, delirium, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, acute renal and / or hepatic insufficiency, convulsions, respiratory paralysis musculature.

Treatment: gastric lavage, saline laxatives, Activated carbon; carrying out forced diuresis, hemodialysis, with the development of convulsive syndrome - intravenous diazepam and high-speed barbiturates.

Interaction:

Radiopaque drugs, colloidal blood substitutes and penicillin should not be used during treatment with metamizole sodium. With the simultaneous use of cyclosporine, the concentration of the latter in the blood decreases.

Metamizole sodium, displacing from the connection with plasma proteins, oral hypoglycemic drugs, indirect anticoagulants, glucocorticosteroids and indomethacin, increases their activity.

Phenylbutazone, barbiturates and other inducers of microsomal liver enzymes with simultaneous use reduce the effectiveness of metamizole sodium.

Simultaneous use with other non-narcotic analgesics, tricyclic antidepressants, contraceptive hormonal drugs and allopurinol may lead to increased toxicity.

Metamizole sodium enhances the effects of ethanol; simultaneous application with chlorpromazine or phenothiazine may lead to the development of severe hyperthermia.

Sedative and anxiolytic drugs (tranquilizers) increase the analgesic effect of metamizole sodium

Thiamazole and cytostatics increase the risk of developing leukopenia.

The effect is enhanced codeine, H2-histamine receptor blockers and propranolol (slows inactivation).

Myelotoxic drugs increase the manifestation of hematotoxicity of the drug.

Special instructions:

In the treatment of patients receiving cytotoxic drugs, metamizole sodium should be administered only under supervision doctor.

Patients with atopic bronchial asthma and pollinosis have an increased risk of developing allergic reactions.

Against the background of taking metamizole sodium, the development of agranulocytosis is possible, therefore, if an unmotivated rise in temperature, chills, sore throats, difficulty swallowing, stomatitis, and the development of the phenomena of vaginitis or proctitis, immediate withdrawal of the drug is necessary. With prolonged use, it is necessary to monitor the picture of peripheral blood.

It is inadmissible to use to relieve acute pain in the abdomen (until the cause is clarified).

Effect on the ability to drive transp. cf. and fur:There is no information.

Form release / dosage:

Tablets 500 mg.

Packaging:

For 10 tablets in a contour non-cellular package of packaging paper.

For 10 tablets in a contour mesh box made of polyvinylchloride film and aluminum foil or paper packaging.

For 1, 2 contour mesh packages with instructions for use are placed in a cardboard pack.

For 20 contour non-jawed or contour mesh packages with an equal number of instructions for use are placed in a cardboard pack.

Contour non-cellular or contour mesh packages with an equal number of instructions for use are placed in a shipping container.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:5 years. Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LS-000487

Date of registration:31.05.2010 / 07.05.2015

Expiration Date:Unlimited

The owner of the registration certificate:UPDATE OF PFC, CJSC UPDATE OF PFC, CJSC Russia

Manufacturer: & nbsp

UPDATE, PFC CJSC Russia

Representation: & nbspUPDATE OF PFC, CJSCUPDATE OF PFC, CJSC

Information update date: & nbsp25.08.2017

Illustrated instructions

Instructions

Analgin (Analgin)