Analgin - instructions for use, dose, side effects, contraindications

It has analgesic, antipyretic and weak anti-inflammatory action, the mechanism of which is associated with oppression of the synthesis of prostaglandins. It is a derivative of pyrazolone.

Pharmacokinetics:

With intravenous administration: the onset of action - through 5-10 min, the maximum effect - through 5-30 min, duration of action - up to 2 hours. Metabolized in the liver, a small concentration of unchanged metamizole sodium is detected in the plasma, excreted by the kidneys. In therapeutic doses penetrates into the mother's milk.

Indications:

Pain syndrome (mild to moderate): incl. neuralgia, myalgia, arthralgia, biliary colic, intestinal colic, renal colic, trauma, burns, decompression sickness, shingles, orchitis, radiculitis, myositis, postoperative pain syndrome, headache, toothache, algodismenorea. Feverish syndrome (infectious and inflammatory diseases, insect bites - mosquitoes, bees, gadflies, etc., posttransfusion complications).

The drug is intended for symptomatic therapy, reducing pain and inflammation at the time of use, the progression of the disease is not affected.

Contraindications:

Hypersensitivity to pyrazolone derivatives (phenylbutazone, tribuzon), the propensity to bronchospasm.

Pronounced violations of the liver and / or kidney function, deficiency of glucose-6-phosphate dehydrogenase, blood diseases, oppression of hematopoiesis (agranulocytosis, cytostatic or infectious neutropenia), as well as anemia and leukopenia.Bronchoconstriction, rhinitis, urticaria caused by the use of acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (including in the anamnesis), active liver disease, condition after aortocoronary shunting; confirmed hyperkalemia, erosive and ulcerative changes in the mucous membrane of the stomach and duodenum, active gastrointestinal bleeding, inflammatory bowel diseases.

Infant age up to 3 months.

Carefully:

Coronary heart disease, chronic heart failure, cerebrovascular disease, dyslipidemia / hyperlipidemia, diabetes mellitus, peripheral arterial disease, smoking, creatinine clearance less than 60 ml / min, anamnestic data on the development of gastrointestinal ulcer, infection of N. pylori, old age, long-term use of non-steroidal anti-inflammatory drugs, severe somatic diseases, simultaneous administration of oral glucocorticosteroids (incl. prednisolone), anticoagulants (incl. warfarin), antiaggregants (incl. acetylsalicylic acid, clopidogrel), selective serotonin reuptake inhibitors (incl. citalopram, fluoxetine, paroxetine, sertraline).

Particular caution is required when appointing patients with systolic blood pressure below 100 mm Hg. Art. or with circulatory instability (for example, with myocardial infarction, multiple trauma, starting shock), with anamnestic indications of kidney disease (pyelonephritis, glomerulonephritis) and with prolonged alcoholic history.

Pregnancy and lactation:Do not use during pregnancy (especially in the first 3 months and the last 6 weeks) and during lactation.

Dosing and Administration:

The drug is administered IV (for severe pain) or IM for 1-2 ml 250 mg / ml or 500 mg / ml solution 2-3 times a day, but not more than 2 g per day.

Children are administered at the rate of 0.1-0.2 ml of a 500 mg / ml solution or 0.2-0.4 ml of a 250 mg / ml solution for every 10 kg of the child's body weight 2-3 times a day.

For children up to 1 year, the drug is administered only in the / m course no more than 3 days.

Side effects:

In therapeutic doses, the drug is well tolerated. When the drug is used in some patients, there may be adverse reactions: allergic reactions (skin rash,angioedema; rarely anaphylactic shock, Stevens-Johnson and Lyell syndromes, bronchospasm); with prolonged use may occur agranulocytosis, leukopenia, thrombocytopenia, arterial hypotension, interstitial nephritis.Violation of kidney function, oliguria, anuria, proteinuria, staining of urine in red.

With propensity to bronchospasm may provoke an attack.

With the / m introduction, infiltrates are possible at the injection site.

Overdose:

Symptoms: nausea, vomiting, gastralgia, oliguria, hypothermia, lowering of arterial pressure, tachycardia, dyspnea, tinnitus, drowsiness, delirium, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, acute renal and / or hepatic insufficiency, convulsions, respiratory muscle paralysis.

Treatment: induction of vomiting, over-the-horizon gastric lavage, saline laxatives, Activated carbon; carrying out forced diuresis, hemodialysis, with the development of convulsive syndrome - intravenous diazepam and high-speed barbiturates.

Interaction:

Because of the high likelihood of pharmaceutical incompatibility, you should not mix it with other drugs in the same syringe.Enhances the effects of ethanol; simultaneous use with chlorpromazine or other phenothiazine derivatives can lead to the development of severe hyperthermia. Radiocontrast agents, colloidal blood substitutes and penicillin should not be used during treatment with metamizole sodium. With the simultaneous administration of cyclosporine, the concentration of the latter in the blood decreases. Metamizol sodium, displacing from the connection with the protein oral hypoglycemic drugs, indirect anticoagulants, glucocorticosteroids and indomethacin, increases their activity. Phenylbutazone, barbiturates and other hepatoinductors with simultaneous administration decrease the effectiveness of metamizole sodium. Simultaneous appointment with other non-narcotic analgesics, tricyclic antidepressants, contraceptive hormonal agents and allopurinol may lead to increased toxicity. Sedatives and tranquilizers increase the analgesic effect of metamizole sodium. Thiamazole and sarcolysin increase the risk of developing leukopenia. The effect is enhanced codeine, histamine H2-blockers and propranolol (slows inactivation).Myelotoxic drugs increase the manifestation of hematotoxicity of metamizole sodium.

Special instructions:

When treating children under 5 years and patients receiving cytotoxic drugs, taking analgin should only be done under the supervision of a doctor. Patients with atopic bronchial asthma and pollinosis have an increased risk of developing hypersensitivity reactions. At long (more than a week) application control of a picture of peripheric blood and a functional status of a liver is necessary. Against the background of taking analgin, the development of agranulocytosis is possible, in connection with which, when an unmotivated rise in temperature, chills, sore throats, difficulty swallowing, stomatitis, and with the development of vaginitis or proctitis, immediate withdrawal of the drug is necessary. Intolerance is very rare, but the threat of developing shock after intravenous administration of the drug is relatively higher than after taking the drug inside. It is not permissible to use to relieve acute pain in the abdomen (until finding out the cause).

With the / m introduction it is necessary to use a long needle.

Form release / dosage:

A solution for intravenous and / or intravenous injection of 250 mg / ml or 500 mg / ml (ampoules) - 1 or 2 ml.

Packaging:

For 10 ampoules together with a knife ampoule or scarifier and instructions for use in a pack of cardboard.

5 ampoules per contour cell pack. 2 contour squares with a knife ampoule or scarifier and instructions for use in a pack of cardboard. When you pack the ampoules with a point or ring of a fracture, the ampoule knife or scarifier does not insert.

Storage conditions:

In dry, dark place, with temperature not higher than 25 ° С. Store in inaccessible to children.

Shelf life:

3 years. Do not use after expiration date indicated on the package.

Terms of leave from pharmacies:On prescription

Registration number:P N001414 / 01

Date of registration:14.05.2009 / 18.09.2014

Expiration Date:Unlimited

The owner of the registration certificate:Armavir Biofactory, FKPArmavir Biofactory, FKP Russia

Manufacturer: & nbsp

ARMAVIRSK BIOLOGICAL FACTORY, FSUE Russia

Information update date: & nbsp27.08.2017

Illustrated instructions

Instructions

Analgin (Analgin)