Analgin - instructions for use, dose, side effects, contraindications

Pharmacodynamics:Megamizol sodium is a derivative of pyrazolone. It has analgesic, antipyretic and weak anti-inflammatory action, the mechanism of which is associated with oppression of the synthesis of prostaglandins. By the mechanism of action is practically no different from other non-staging anti-inflammatorypreparations.

Pharmacokinetics:

After intravenous administration, the elimination half-life for metamizole is 14 minutes. Approximately 96% is excreted in the urine in the form of metabolites. The association of an active metabolite with blood plasma proteins is 50-60%. It is mainly excreted by the kidneys.

Indications:

Pain syndrome of different etiology (acute or chronic): incl. headache, migraine, toothache, neuralgia, myalgia, radicular syndrome, algodismenorea: with renal, hepatic and biliary colic (in combination with antispasmodics).

Analgin can be used to reduce pain after surgical and diagnostic interventions.

The raised temperature of a body at "catarrhal" and other infectious-inflammatory diseases. The expediency of using the drug is decided in each case, depending on the severity, nature and tolerability of the fever.

Contraindications:

- Hypersensitivity to pyrazolone derivatives (isopropylaminofenazole, propifenazole, phenazone or phenylbutazone);

- bronchial asthma; diseases accompanied by bronchospasm;

- expressed violations of hematopoiesis (agranulocytosis, cytoplastic and infectious neutropenia);

- marked violations of the liver or kidneys;

- hepatic porphyria;

- congenital deficiency of glucose-6-phosphate dehydrogenase;

- pregnancy (especially in the first trimester and in the last 6 weeks);

- Infant age (up to 3 months with a body weight of less than 5 kg).

Pregnancy and lactation:

During the first and last three months of pregnancy, you can not take Analgin. From the fourth to the sixth months of pregnancy, Analgin should be taken with strict medical indications. After taking Analgin, breast-feeding should be stopped for 48 hours.

Dosing and Administration:

Adults and adolescents 15 years and older: As a single dose, 1-2 ml of 50% (500 mg / 1 ml) or 2-4 ml of a 25% solution of Analgin is recommended (IM or IV), the daily dose can be up to 4-8 ml of 50% or 25 % of the injection solution (not more than 2 g), divided into 2 to 3 administration. The maximum single dose may be 1 g (2 ml of a 50% solution or 4 ml of a 25% solution).

Children and newborns: Analginum should not be taken to newborns before the age of 3 months or at a body weight of less than 5 kg.

Children Analgin is prescribed in a dose of 50-100 mg per 10 kg of body weight (0.1-0.2 ml of a 50% solution or 0.2-0.4 ml of a 25% solution).

A single dose can be prescribed up to 2-3 times a day.

Before administration, the solution is recommended to be heated to body temperature.

For children aged 3-12 months, the introduction is only intramuscular! (weight of the child from 5 to 9 kg).

With too rapid administration of the drug, a critical drop in blood pressure and shock can occur. Intravenous administration should be slow (the rate of administration is not more than 1 ml (500 mg metamizole per minute) in the supine position, while monitoring blood pressure, pulse and respiration rate.

Since there is a concern that the drop in arterial pressure of non-allergic genesis is dose-dependent, the amount of Analgin solution is more than 2 ml (1 g) should be administered with extreme caution.

Side effects:

Allergic reactions: urticaria, including on the conjunctiva and mucous membranes of the nasopharynx, Quincke's edema; in rare cases - malignant exudative erythema (Stevens-Johnson syndrome), anaphylactic shock, toxic epidermal necrolysis (Lyell's syndrome), bronchospastic syndrome;

On the part of the organs of hematopoiesis: leukopenia, rarely agranulocytosis and thrombocytopenia of immune genesis;

From the urinary system: renal dysfunction, oliguria, anuria, protenuria, very rarely the development of acute interstitial nephritis, staining the urine in red (due to the release of the metabolite - rubanzonovoy acid).

Other: possible lowering of blood pressure, violation of heart rate.

Overdose:

In case of overdose, consult a physician. The following symptoms may appear: nausea, vomiting, stomach pain, oliguria, hypothermia, lowering of arterial pressure, tachycardia, dyspnea, tinnitus, drowsiness, delirium, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, acute renal and / or hepatic insufficiency, convulsions, paralysis of the respiratory musculature.

Treatment: symptomatic. There is no specific antidote for metamizole. AT conditions of the medical institution - conducting forced diuresis, hemodialysis, with the development of convulsive syndrome - intravenous diazepam and high-speed barbiturates.

Interaction:

Simultaneous use of Analgin with other non-narcotic analgesics can lead to mutual enhancement of toxic effects.

Tricyclic antidepressants, contraceptives for oral administration and allopurinol disrupt metamizole metabolism in the liver and increase its toxicity. Barbiturates and phenylbutazone weaken the action of analgin.

Analgin increases the effects of alcohol-containing beverages.

Radiocontrast agents, colloidal blood substitutes and penicillin should not be used during metamizole treatment.

Metamizole, displacing from the bond with protein oral hypoglycemic drugs, indirect anticoagulants, glucocorticosteroids and indomethacin, increases their activity.

Simultaneous use of Analgin with cyclosporine reduces the level of the latter in the blood. Thiamazole and sarcolysin increase the risk of developing leukopenia.

The effect is enhanced codeine, propranolol (slows inactivation).

Sedatives and tranquilizers increase the analgesic effect of analgin. Because of the high likelihood of pharmaceutical incompatibility, metamizole should not be mixed with other drugs in the same syringe.

Special instructions:

Patients suffering from bronchial asthma and hay fever may develop sensitivity reactions.

With prolonged use (more than 7 days), you need to monitor the picture of peripheral blood. Against the background of taking metamizole sodium, the development of agranulocytosis is possible, therefore, if an unmotivated rise in temperature, chills, sore throats, difficulty swallowing, stomatitis, erosive-ulcerative lesions of the oral cavity, vaginitis or proctitis is required, immediate withdrawal of the drug is necessary.

Do not apply to relieve acute pain in the abdomen (until finding out the reasons).

In the treatment of patients receiving cytotoxic drugs, metamizole sodium intake should be performed only under the supervision of a physician.

Particular caution is required when appointing patients with systolic blood pressure below 100 mm Hg. or in case of circulatory instability (for example, in case of severe cardiovascular disorders beginning with myocardial infarction, multiple trauma starting with shock), with anamnestic indications of kidney diseases (pyelonephritis, glomerulonephritis) and long-term alcoholic history. With the / m introduction it is necessary to use a long needle.

Form release / dosage:

Solution for intravenous and intramuscular injection.

Packaging:

In ampoules of 1 or 2 ml.

For 10 ampoules together with a knife for opening ampoules and instructions for use are placed in a cardboard box. 10 ampoules in a blister pack; 1 or 2 packages together with a knife for opening ampoules and instruction on application put in a pack of cardboard.

In the case of using ampoules with a fracture ring or a notch and point fracture, the insertion of a knife for opening ampoules is not envisaged.

Storage conditions:

List B. In sheltered from light, at temperatures from +5 to +30 ° C, inaccessible to children.

Shelf life:3 years. Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LS-000904

Date of registration:18.08.2010 / 22.04.2015

Expiration Date:Unlimited

The owner of the registration certificate:BORISOVSKIY FACTORY OF MEDPREPARATES, OJSC BORISOVSKIY FACTORY OF MEDPREPARATES, OJSC Republic of Belarus

Manufacturer: & nbsp

BORISOVSKIY FACTORY OF MEDPREPARATES, OJSC Republic of Belarus

Representation: & nbspBORISOVSKIY FACTORY OF MEDPREPARATES, OJSCBORISOVSKIY FACTORY OF MEDPREPARATES, OJSC

Information update date: & nbsp25.08.2017

Illustrated instructions

Instructions

Analgin (Analgin)