Coronary heart disease, chronic heart failure, cerebrovascular disease, dyslipidemia / hyperlipidemia, diabetes mellitus, peripheral arterial disease, smoking, creatinine clearance less than 60 ml / min, anamnestic data on the development of gastrointestinal ulcer, infection of N. pylori, elderly age, long-term use of non-steroidal anti-inflammatory drugs, severe somatic diseases, simultaneous administration of oral glucocorticosteroids (incl. prednisolone), anticoagulants (incl. warfarin), antiaggregants (incl. acetylsalicylic acid, clopidogrel), selective serotonin reuptake inhibitors (incl. citalopram, fluoxetine, paroxetine, sertraline).
Particular caution is required when appointing patients with systolic blood pressure below 100 mm Hg. Art. or with circulatory instability (for example, with myocardial infarction, multiple trauma, starting shock), with anamnestic indications of kidney disease (pyelonephritis, glomerulonephritis) and with prolonged alcoholic history.