Analgin - instructions for use, dose, side effects, contraindications

Metamizole sodium is a derivative of pyrazolone. It has analgesic, antipyretic and weak anti-inflammatory action, the mechanism of which is associated with oppression of the synthesis of prostaglandins.Pharmacological action develops 20-40 minutes after taking the drug and reaches a maximum after 2 hours.

Pharmacokinetics:

Indications:Pain syndrome of different etiology (headache, migraine, toothache, neuralgia, myalgia, algodismenorea, postoperative pain); with renal and biliary colic (in combination with antispasmodics). Feverish conditions with infectious and inflammatory diseases.

Contraindications:

- Hypersensitivity to pyrazolone derivatives (butadione, tribuzone);

- bronchial asthma; diseases accompanied by bronchospasm;

- "aspirin asthma";

- oppression hemopoiesis (agranulocytosis, neutropenia, leukopenia);

- severe dysfunction of the liver or kidney; blood diseases;

- hereditary hemolytic anemia associated with a deficiency of glucose-6-phosphate dehydrogenase;

- pregnancy (especially in the first trimester and in the last 6 weeks), lactation.

Carefully:Infant age (up to 3 months).

Pregnancy and lactation:Contraindicated.

Dosing and Administration:

It is used in adults for 1 tablet 2-3 times a day after meals.The maximum single dose is 1 g (2 tablets), daily - 3 g (6 tablets). With prolonged (more than a week) application of the drug, control of the picture of peripheral blood and the functional state of the liver is necessary.

Children are prescribed 5-10 mg / kg body weight 3-4 times a day for not more than 3 days (previously crushed tablet).

Do not use (without consulting a doctor) more than 3 days when prescribed as an antipyretic agent and more than 5 days - when prescribed as an anesthetic.

Side effects:

When using tablets of analgin, there may be side effects:

- allergic reactions: skin rash, angioedema; rarely - anaphylactic shock, toxic epidermal necrolysis (Lyell's syndrome), in rare cases - Stevens-Johnson syndrome;

- with prolonged use may occur leukopenia, thrombocytopenia, agranulocytosis;

- with propensity to bronchospasm may provoke an attack;

- lowering of blood pressure.

There may be a violation of kidney function, oliguria, anuria, protenuria, interstitial nephritis, urine staining in red due to the release of a metabolite.

All side effects (including those not mentioned above) should be reported to the doctor in charge and stop taking the drug.

Overdose:

With prolonged use of the drug (more than 7 days) in large doses, the following symptoms of overdose may occur: nausea, vomiting, gastralgia, oliguria, hypothermia, lowering of arterial pressure, tachycardia, dyspnea, tinnitus, drowsiness, delirium, impaired consciousness, agranulocytosis, hemorrhagic syndrome, acute renal and / or hepatic insufficiency, convulsions, paralysis of the respiratory musculature.

Treatment: cause vomiting, make a lavage of the stomach, take saline laxatives, Activated carbon. In the conditions of a medical institution - conducting forced diuresis, hemodialysis, with the development of convulsive syndrome - intravenous diazepam and barbiturates.

Interaction:

Simultaneous use of Analgin with other non-narcotic analgesics can lead to mutual enhancement of toxic effects.

Tricyclic antidepressants, contraceptives for oral administration and allopurinol disrupt metamizole metabolism in the liver and increase its toxicity. Barbiturates and phenylbutazone weaken the action of analgin.

Analgin increases the effects of alcohol-containing beverages.

Radiocontrast agents, colloidal blood substitutes and penicillin should not be used during metamizole treatment.

Metamizole, displacing from the bond with protein oral hypoglycemic drugs, indirect anticoagulants, glucocorticosteroids and indomethacin, increases their activity.

Simultaneous use of Analgin with cyclosporine reduces the level of the latter in the blood. Thiamazole and sarcolysin increase the risk of developing leukopenia.

The effect is enhanced codeine, propranolol (slows inactivation).

Sedatives and tranquilizers increase the analgesic effect of analgin.

Special instructions:

Patients suffering from bronchial asthma and hay fever may develop sensitivity reactions.

With prolonged use (more than 7 days), you need to monitor the picture of peripheral blood.

Do not apply to relieve acute pain in the abdomen (until finding out the reasons).

When treating children under 5 years and patients receiving cytotoxic drugs, the use of metamizole sodium should only be done under the supervision of a doctor.

Special caution is required when prescribing to patients who abuse alcohol drinks.

Children up to 2 years are recommended to use children's dosage forms.

Children and adolescents under 18 years of age should be used only as directed by a doctor.

Form release / dosage:

Tablets of 0.5 g.

Packaging:

For 10 or 20 tablets in cans of glass glass of orange glass; 10 tablets in a contour cell or cell-free packaging.

Each bank or 1, 2 contour packs together with the instruction for use are placed in a pack of cardboard.

For 150 contiguous cell-free cells and 200 contour cell packs, together with instructions for use, are placed in a cardboard box (for inpatient).

Storage conditions:

In a dry place, protected from light, out of reach of children.

Shelf life:

5 years. Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:P N001780 / 02

Date of registration:20.11.2008

Expiration Date:Unlimited

The owner of the registration certificate:BIOCHEMIST, OJSC BIOCHEMIST, OJSC Russia

Manufacturer: & nbsp

BIOCHEMIST, OJSC Russia

Representation: & nbspBIOCHEMICAL JSC BIOCHEMICAL JSC Russia

Information update date: & nbsp26.08.2017

Illustrated instructions

Instructions

Analgin (Analgin)