Analgin - instructions for use, dose, side effects, contraindications

A distinctive feature is the slight severity of the anti-inflammatory effect, which causes a weak effect on water-salt metabolism (delay Na⁺ and water) and the mucous membrane of the gastrointestinal tract. Has analgesic, antipyretic and some spasmolytic (with respect to the smooth muscles of the urinary and biliary tract) action.

The effect develops 20-40 minutes after ingestion and reaches a maximum after 2 hours.

Pharmacokinetics:

Good and quickly absorbed into the gastrointestinal tract.

In the intestinal wall it hydrolyzes with the formation of an active metabolite - unchanged metamizole in the blood is absent (only after intravenous administration its insignificant concentrations are detected in the plasma).

The association of the active metabolite with proteins is 50-60%.

Metabolized in the liver, excreted by the kidneys.

In therapeutic doses penetrates into the mother's milk.

Indications:

Feverish syndrome (infectious and inflammatory diseases, insect bites - mosquitoes, bees, gadflies, etc., posttransfusion complications).

Pain syndrome (mild to moderate): incl. neuralgia, myalgia, arthralgia, intestinal colic, renal colic, trauma, burns, decompression sickness, shingles, orchitis of sciatica, myositis, postoperative pain syndrome, headache, toothache, algodismenorea, etc.

Contraindications:

Hypersensitivity, oppression of hematopoiesis (agranulocytosis, cytostatic or infectious neutropenia), hepatic and / or renal failure, hereditary hemolytic anemia associated with deficiency of glucose-6-phosphate dehydrogenase, asthma induced by acetylsalicylic acid, salicylates and other non-steroidal anti-inflammatory drugs, anemia, leukopenia , pregnancy (especially in the first trimester and in the last 6 weeks), lactation period.

Carefully:

Kidney disease (pyelonephritis, glomerulonephritis - including in the anamnesis), prolonged abuse of ethanol.

Children up to 8 years.

Pregnancy and lactation:Contraindicated.

Dosing and Administration:Inside after eating 250-500 mg 2-3 times a day, the maximum single dose - 1 g, daily - 3 g. Single doses for children 8-14 years - 250-300 mg, the frequency of appointment - 2-3 times a day .

Side effects:

From the urinary system: renal dysfunction, oliguria, anuria, proteinuria, interstitial nephritis, urine staining in red.

Allergic reactions: urticaria (including conjunctiva and mucous membranes of the nasopharynx), angio-neurotic edema,in rare cases - malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell syndrome), bronchospastic syndrome, anaphylactic shock.

On the part of the organs of hematopoiesis: agranulocytosis, leukopenia, thrombocytopenia.

Other: lowering of blood pressure.

Overdose:

Symptoms: nausea, vomiting, gastralgia, oliguria, hypothermia, lowering of arterial pressure, tachycardia, dyspnea, tinnitus, drowsiness, delirium, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, acute renal and / or hepatic insufficiency, convulsions, respiratory muscle paralysis.

Treatment: gastric lavage, saline laxatives, Activated carbon, carrying out forced diuresis, hemodialysis, with the development of convulsive syndrome - iv injection of diazepam and high-speed barbiturates.

Interaction:

Enhances the effects of ethanol; simultaneous use with chlorpromazine or other derivatives of phenothiazine may lead to the development of severe hyperthermia.

Radiopaque drugs, colloidal blood substitutes and penicillin should not be used during treatmentmetamizole.

With the simultaneous administration of cyclosporine, the concentration of the latter in the blood decreases. Metamizole, displacing from the connection with protein oral hypoglycemic drugs, indirect anticoagulants, glucocorticosteroids and indomethacin, increases their activity. Phenylbutazone, barbiturates and other hepatoinducers with simultaneous administration decrease the effectiveness of metamizole.

Simultaneous appointment with other non-narcotic analgesics, tricyclic antidepressants, contraceptive hormonal medications and allopurinol may lead to increased toxicity.

Sedative and anxiolytic drugs (tranquilizers) increase the analgesic effect of metamizole.

Thiamazole and cytostatics increase the risk of developing leukopenia.

The effect is enhanced codeine, H₂-gistaminoblockers and propranolol (slows inactivation). Myelotoxic drugs - increased hematotoxicity.

Special instructions:

When treating children and patients receiving cytotoxic drugs, metamizole sodium intake should only be performed under the supervision of a doctor.

Intolerance is very rare, but the threat of anaphylactic shock after IV injection is relatively higher than after taking the drug inside. Patients with atopic bronchial asthma and pollinosis have an increased risk of developing allergic reactions.

Against the background of taking metamizole sodium, the development of agranulocytosis is possible, in connection with which, when an unmotivated rise in temperature, chills, sore throats, shortness of breath, stomatitis, and the development of vaginitis or proctitis, immediate withdrawal of the drug is necessary. With prolonged use, it is necessary to monitor the picture of peripheral blood.

It is inadmissible to use to relieve acute pain in the abdomen (until the cause is clarified).

It is possible to stain urine in red by excretion of the metabolite (it has no value).

Form release / dosage:

Tablets 0.5 g.

Packaging:10 tablets per contour cell pack. For 1, 2 contour squares, together with instructions for use, are placed in a pack of cardboard. 10 tablets per contour bezcell packaging. Contour non-jammed packages with an equal number of instructions for use are placed in a grouppacking.

Storage conditions:

In the dark place at a temperature of no higher than 30 ° C.

Keep out of the reach of children.

Shelf life:

5 years. Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:P N000351 / 01

Date of registration:26.02.2008 / 05.04.2017

Expiration Date:Unlimited

The owner of the registration certificate:ORGANICS, JSC ORGANICS, JSC Russia

Manufacturer: & nbsp

ORGANICS, JSC Russia

Information update date: & nbsp25.08.2017

Illustrated instructions

Instructions

Analgin (Analgin)