Analgin - instructions for use, dose, side effects, contraindications

Metamizole sodium - an analgesic non-narcotic agent, a derivative of pyrazolone, nonselectively blocks cyclooxygenase and reduces the formation of prostaglandins from arachidonic acid.

Prevents painful extra- and proprioceptive pulses along the Gaull and Burdach beams, raises the threshold of excitability of thalamic pain centers sensitivity, increases heat transfer.

A distinctive feature is the slight severity of the anti-inflammatory effect, which causes a weak effect on water-salt metabolism (retention of sodium and water ions) and the mucous membrane of the gastrointestinal tract. Has analgesic, antipyretic and some spasmolytic (with respect to the smooth muscles of the urinary and biliary tract) action.

The effect develops 20-40 minutes after ingestion and reaches a maximum after 2 hours.

Pharmacokinetics:

Good and quickly absorbed in the gastrointestinal tract.

In the intestinal wall it hydrolyzes with the formation of an active metabolite - unchanged metamizol sodium in the blood is absent (only after intravenous administration of an insignificant of its concentration is detected in the plasma).

The association of the active metabolite with proteins is 50-60%.

Metabolized in the liver, excreted by the kidneys.

In therapeutic doses penetrates into breast milk.

Indications:

- Feverish syndrome (infectious and inflammatory diseases, insect bites - mosquitoes, bees, gadflies and others, post-transfusion complications);

- pain syndrome (mild to moderate) incl. neuralgia, myalgia, arthralgia, trauma, burns, decompression sickness, shingles, orchitis, radiculitis, myositis, post-operative pain syndrome, headache, toothache, algodismorrhoea.

- pain syndrome with bile, intestinal, renal colic - in combination with appointment antispasmodics.

Contraindications:

- Dhypersensitivity;

- oppression of hematopoiesis (agranulocytosis, cytostatic or infectious neutropenia);

- hepatic and / or renal insufficiency;

- hereditary hemolytic anemia associated with a deficiency of glucose-6-phosphate dehydrogenase;

- bronchial asthma, induced by the use of acetylsalicylic acid, salicylates or other non-steroidal anti-inflammatory drugs;

- anemia;

- leukopenia;

- age up to 8 years.

Carefully:

- Зkidney kidneys (pyelonephritis, glomerulonephritis - including in the anamnesis);

- prolonged abuse of ethanol;

- diabetes mellitus (due to the presence of sugar in the composition).

Pregnancy and lactation:Analginum is contraindicated in pregnancy (I and III trimesters) and during lactation. In the second trimester of pregnancy, taking the drug is only possible for lifeth indications.

Dosing and Administration:

Analgin should be administered orally, for children from age 14 and adults, 250 to 500 mg (1/2 to 1 tablet) 2-3 times per day, the maximum single dose is 1000 mg (2 tablets), daily - 3000 mg (6 tablets ).

Single dose for children 8-14 years - 250 mg, the frequency of appointment - 2-3 times a day. The drug should not be used (without consultation with a doctor) for more than 3 days if given in quality antipyretics and more than 5 days - when appointed as painkiller facilities.

Side effects:

From the urinary system: renal dysfunction, oliguria, anuria, proteinuria, interstitial nephritis, urine staining in red.

On the part of the organs of hematopoiesis: agranulocytosis, leukopenia, thrombocytopenia.

Allergic reactions: urticaria (including on the conjunctiva and mucous membranes of the nasopharynx), angioedema, in rare cases - malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), bronchospastic syndrome, anaphylactic shock.

Other: lowering of blood pressure.

Overdose:

Symptoms: nausea, vomiting, gastralgia, oliguria, hypothermia, lowering of arterial pressure, tachycardia, dyspnea, tinnitus, drowsiness, delirium, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, acute renal and / or hepatic failure, convulsions, paralysis of the respiratory musculature.

Treatment: gastric lavage, saline laxatives, Activated carbon; carrying out forced diuresis, hemodialysis, with the development of convulsive syndrome - intravenous diazepam and high-speed barbiturates.

Interaction:

Metamizol sodium strengthens effects of ethanol

Radiopaque drugs, colloidal blood substitutes and penicillin should not used during treatment with metamizole sodium.

With the simultaneous use of cyclosporine decreases concentration of the latter in the blood.

With simultaneous application metamizol sodium displaces out of association with the protein and increases the activity of oral hypoglycemic drugs, indirect anticoagulants, glucocorticosteroids; indomethacin.

With the simultaneous use of sedative and anxiolytic drugs (tranquilizers) reinforce analgesic effect of metamizole sodium.

With simultaneous application codeine, H2-histamine receptor blockers, propranolol reinforce effect (slow inactivation) metamizole sodium.

With simultaneous application phenylbutazone, barbiturates and other hepatoinducers reduce efficacy of metamizole sodium.

The simultaneous use of other non-narcotic analgesics, tricyclic antidepressants, contraceptive hormonal medications, allopurinol may lead to enhance the toxicity of metamizole sodium.

Simultaneous use of myelotoxic drugs strengthens manifestations of hematotoxicity of the drug.

With simultaneous application thiamazole and cytotoxic agents increase the risk of developing leukopenia.

Special instructions:

In the treatment of patients receiving cytotoxic drugs, metamizole sodium should be administered only under medical supervision.

Intolerance is very rare, but the threat of anaphylactic shock after intravenous administration of the drug is relatively higher than after administration preparation inside.Patients with atopic bronchial asthma and pollinosis have an increased risk of developing allergic reactions.

While taking metamizole sodium may develop agranulocytosis, in connection with which the detection unmotivated rise in temperature, fever, sore throat, difficulty swallowing, stomatitis, and the development of phenomena of vaginitis, or proctitis require immediate removal of the drug long-term use is necessary to control the picture of peripheral blood .

It is inadmissible to use to relieve acute pain in the abdomen (until the cause is clarified).

It is possible to stain urine in red by excretion of the metabolite (it has no value).

Form release / dosage:

Tablets of 500 mg.

Packaging:

For 10 pieces in a planar cell pack.

10 pieces in contour non-jam packed.

1, 2, 5 contour mesh or non-jammed packages together with the instruction for use are placed in a pack of cardboard.

It is allowed to place contour packs together with an equal number of instructions for use in group packaging.

Storage conditions:

In a dry place protected from light.

Keep out of the reach of children.

Shelf life:

5 years.Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:P N002062 / 01-2003

Date of registration:09.02.2009

Expiration Date:Unlimited

The owner of the registration certificate:MEDISORB, CJSC MEDISORB, CJSC Russia

Manufacturer: & nbsp

MEDISORB, CJSC Russia

Information update date: & nbsp24.08.2017

Illustrated instructions

Instructions

Analgin (Analgin)