Analgin - instructions for use, dose, side effects, contraindications

Analgin has an analgesic, antipyretic and weak anti-inflammatory effect, the mechanism of which is associated with the inhibition of the synthesis of prostaglandins. It is a derivative of pyrazolone.

Pharmacokinetics:

When ingested quickly and fully absorbed. In the intestinal wall it hydrolyzes with the formation of an active metabolite - low-grade metamizole in the blood is absent. The level of binding of the active metabolite with proteins is 50-60%. Destroyed in the liver. Excretion passes through the kidneys.

The action develops in 20-40 minutes and reaches a maximum after 2 hours.

Indications:

Weak and moderately severe pain syndrome (headache, migraine, toothache, neuralgia, myalgia, dysmenorrhea, postoperative pain, in combination with spasmolytic drugs in renal and biliary colic). Feverish conditions with infectious and inflammatory diseases. Use as an antipyretic agent is advisable after the diagnosis of the disease.

Contraindications:

Hypersensitivity to pyrazolone derivatives (phenylbutazone, tribuzon), the propensity to bronchospasm. Pronounced violations of the liver or kidney function, hereditary hemolytic anemia associated with a deficiency of glucose-6-phosphate dehydrogenase, a blood disease. Bronchoconstriction, rhinitis, urticaria, provoked by the use of acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (NSAIDs) (incl.in the anamnesis), the condition after CABG; confirmed hyperkalemia, erosive and ulcerative changes in gastric mucosa and 12 duodenal ulcer, active gastrointestinal bleeding, inflammatory bowel disease, oppression blood (agranulocytosis, cytostatic or infectious neutropenia, anemia), pregnancy, lactation, children under 8 years old.

Carefully:

Coronary heart disease, chronic heart failure, cerebrovascular disease, dyslipidemia / hyperlipidemia, diabetes mellitus, peripheral arterial disease, smoking, CC less than 60 ml / min, anamnestic data on the development of ulcerative lesions of the gastrointestinal tract, the presence of infection N. pylori, old age, long-term use of NSAIDs, frequent alcohol use, severe somatic diseases, simultaneous administration of oral glucocorticosteroids (incl. prednisolone), anticoagulants (incl. warfarin), antiplatelet agents (including acetylsalicylic acid, clopidogrel), selective serotonin reuptake inhibitors (incl. citalopram, fluoxetine, paroxetine, sertraline).

Pregnancy and lactation:Contraindicated.

Dosing and Administration:

Inside after eating 250-500 mg 2-3 times a day.

The maximum single dose is 1 g (2 tablets), daily - 3 g (6 tablets).

Single dose for children 8-14 years - 250 mg, the frequency of appointment - 2-3 times a day.

Side effects:

From the urinary system: renal dysfunction, oliguria, anuria, proteinuria, interstitial nephritis, staining of urine in red (due to release of metabolite - rubanzonovoy acid). -

Allergic reactions: urticaria (including on conjunctiva and mucous membranes of the nasopharynx), Quincke's edema; in rare cases - malignant exudative erythema (Stevens-Johnson syndrome), anaphylactic shock, toxic epidermal necrolysis (Lyell's syndrome), bronchospastic syndrome (not only with a tendency to bronchospasm).

On the part of the organs of hematopoiesis: leukopenia, rarely agranulocytosis and thrombocytopenia of immune genesis.

Other: it is possible to lower blood pressure.

Overdose:

Symptoms: nausea, vomiting, stomach pain, oliguria, hypothermia, lowering of arterial pressure, tachycardia, dyspnea, tinnitus, drowsiness, delirium, impaired consciousness,acute agranulocytosis, hemorrhagic syndrome, acute renal and / or hepatic insufficiency, convulsions, paralysis of the respiratory musculature.

Treatment: gastric lavage, saline laxatives, Activated carbon; carrying out forced diuresis, hemodialysis, with the development of convulsive syndrome - intravenous diazepam and high-speed barbiturates.

Interaction:

Simultaneous use of analgin with other non-narcotic analgesics can lead to mutual enhancement of toxic effects.

Tricyclic antidepressants, oral contraceptives and allopurinol disrupt the metabolism of metamizole sodium in the liver and increase its toxicity. Barbiturates and phenylbutazone weaken the action of analgin.

Analgin increases the effects of ethanol.

Radiopaque drugs, colloidal blood substitutes and penicillin should not be used during treatment with metamizole sodium.

Metamizole sodium, displacing from the bond with protein oral hypoglycemic drugs, indirect anticoagulants, glucocorticosteroids and indomethacin, increases their activity.Simultaneous use of analgin with cyclosporine reduces the level of the latter in the blood. Thiamazole and cytostatics increase the risk of developing leukopenia.

The effect is enhanced codeine, H2-histamine receptor blockers and propranolol (slows inactivation).

Sedatives and tranquilizers increase the analgesic effect of analgin. Myelotoxic drugs increase the manifestation of hematotoxicity of the drug.

Because of the high likelihood of pharmaceutical incompatibility, metamizole should not be mixed with other drugs in the same syringe.

Special instructions:

In the treatment of patients receiving cytotoxic drugs, the use of metamizole sodium should only be performed under the supervision of a physician.

Patients with atopic bronchial asthma and pollinosis have an increased risk of developing allergic reactions.

While taking metamizole sodium agranulocytosis may develop, due to which the detection unmotivated rise in temperature, fever, sore throat, difficulty swallowing, stomatitis, erosive-ulcerous lesions of the oral cavity, vaginitis, or proctitis, require immediate removal of the drug.

With prolonged use, it is necessary to monitor the picture of peripheral blood. It is unacceptable to use to relieve acute pain in the abdomen (until finding out the reasons). To reduce the risk of developing adverse events from the gastrointestinal tract, a minimally effective dose should be used with the minimum possible short course. Children and adolescents under 18 years of age should be used only as directed by a doctor.

Form release / dosage:

Tablets 500 mg.

Packaging:

For 10 tablets in a contiguous, non-jellied package or a contiguous cell package. For 100 contour (cell or non-cellular) packages with an equal number of instructions for use in a cardboard box.

For 10 tablets in cans of orange glass or cans of polymeric.

Each jar or 1, 2 contour mesh packages together with instructions for use in a pack of cardboard.

Storage conditions:In a dry place, protected from light, out of reach of children, at a temperature not exceeding 25 ° C.

Shelf life:

5 years. Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:P N001286 / 01

Date of registration:18.11.2008

Expiration Date:Unlimited

The owner of the registration certificate:BIOSINTEZ, PAO BIOSINTEZ, PAO Russia

Manufacturer: & nbsp

BIOSINTEZ, PAO Russia

Information update date: & nbsp24.08.2017

Illustrated instructions

Instructions

Analgin (Analgin)