Chlorhexidine - instructions for use, dose, side effects, contraindications

A solution of chlorhexidine bigluconate 20% - 2.5 ml, 10 ml, 25 ml, 50 ml, 250 ml equivalent to chlorhexidine biglucanate 0.5 g, 2 g, 5 g, 10 g, 50 g;

Waters purified to 1000.0 ml

Description:

Colorless or light yellow transparent, slightly opalescent liquid, odorless or with a faint odor.

Pharmacotherapeutic group:Antiseptic.

ATX: & nbsp

D.08.A.C.02 Chlorhexidine

G.01.A.X Other antiseptics and antimicrobials for the treatment of gynecological diseases

Pharmacodynamics:

Antiseptic and disinfectant. Depending on the concentration used, it shows bacteriostatic and bactericidal effects against Gram-positive and Gram-negative bacteria.

Effective against causative agents of sexually transmitted infections - gardnerellez, genital herpes; Gram-positive and Gram-negative bacteria - Treponema spp., Neisseria gonorrhoeae, Trichomonas spp., Chlamidia spp., Ureaplasma spp. He acts on acid-fast forms of bacteria, microbial spores, fungi.

Stable, after treatment of the skin (hands, operating field) is stored on it in a certain amount, sufficient for the manifestation of bactericidal effect. Keeps activity (although somewhat reduced) in the presence of blood, pus, various secrets and organic substances. Very rarely causes allergic reactions, skin and tissue irritation, does not have a damaging effect on objects made of glass, plastics and metals.

Pharmacokinetics:

Virtually not absorbed from the gastrointestinal tract.After accidental ingestion of 300 mg, the maximum concentration is reached after 30 minutes and is 0.206 μg / L. It is excreted primarily through the intestine (90%), less than 1% is excreted by the kidneys.

Indications:

0.05% and 0.2% solution:

prevention of infections (no later than 2 hours after sexual intercourse), sexually transmitted (chlamydia, ureaplasmosis, trichomoniasis, gonorrhea, syphilis, genital herpes); disinfection of the skin (scrapes, cracks); purulent wounds, infected burns, bacterial and fungal diseases skin and mucous membranes of the urino-genital organs, in stomatology (rinsings and irrigation - gingivitis, stomatitis, aphthae, paradontitis, alveolitis).

0.5% solution:

Treatment of wounds and burns; treatment of infected scuffs, skin cracks and open mucous membranes. For sterilization of a medical instrument at a temperature of 70 ° C; disinfection of working surfaces of devices (including thermometers) and equipment, the thermal treatment of which is undesirable.

1% solution:

Disinfection of thermometers, working surfaces of medical equipment and devices whose heat treatment is undesirable, treatment of the surgical field and hands of the surgeon before surgery, skin disinfection, treatment postoperative and burn wounds.

5% solution:

Preparation of aqueous, glycerin and alcohol solutions with concentrations from 0.01 to 1%.

Contraindications:

Hypersensitivity, dermatitis.

Carefully:child age, pregnancy, lactation

Dosing and Administration:

0.05% and 0.2% solutions are applied topically and externally.

5 - 10 ml of the solution is applied to the affected surface of the skin or mucous membranes of the urogenital organs, the oral cavity 1-3 minutes 2-3 times per day (on a tampon or by irrigation).

For the prevention of sexually transmitted diseases, the contents of the vial with the help of a nozzle should be inserted into the urethra for men (2 to 3 ml), for women (1-2 ml) and for the vagina (5-10 ml) for 2-3 min. After the procedure, it is recommended not to urinate for 2 hours. Treat the skin of the inner surfaces of the hips, pubic area, genitals.

In case of contact with the mucous membranes of the eye, they should be washed quickly and thoroughly with water.

0.5% solution is applied topically and externally.

In the form of irrigation, rinses and applications - 5-10 ml of the solution is applied to the affected surface of the skin or mucous membranes with an exposure of 1-3 minutes 2-3 times per day (on a tampon or by irrigation).

The treatment of the medical instrument and working surfaces is carried out with a clean sponge moistened with the drug solution or by soaking.

In case of contact with the mucous membranes of the eye, they should be washed quickly and thoroughly with water.

1% solution is applied externally.

Hands of the surgeon before treatment with a solution of antiseptic thoroughly wash with soap and wipe, thoroughly wash the antiseptic hands (20-30 ml). Treatment of the skin of the postoperative wounds is done with a clean swab.

The treatment of the medical instrument and working surfaces is carried out with a clean sponge moistened with the drug solution or by soaking.

In case of contact with the mucous membranes of the eye, they should be washed quickly and thoroughly with water.

5% solution:

Concentrate is diluted from the calculation of the working concentration of the prepared solution.

Side effects:Allergic reactions, dry and itchy skin, dermatitis, photosensitivity. When treatment of oral diseases - tooth enamel staining, scaling, taste disorder, stickiness of the skin of hands (within 3-5 min).

Interaction:

Pharmaceutically incompatible with soap, alkalis and other anionic compounds (colloids, gum arabic, carboxymethyl cellulose). Compatible with preparations containing a cationic group (benzalkonium chloride, cetrimonium bromide).Increases the sensitivity of bacteria to chloramphenicol, kanamycin, neomycin, cephalosporins. Ethanol strengthens the effectiveness of the drug.

Special instructions:

In patients with open TBI, damage to the spinal cord, perforation of the tympanic membrane, one should avoid getting onto the surface of the brain, the meninges and into the cavity of the inner ear. In case of contact with the mucous membranes of the eye, they should be washed quickly and thoroughly with water.

The contact of hypochlorite bleaching substances on tissues that previously were in contact with the containing chlorhexidine drugs, can promote the appearance of brown spots on them. The bactericidal effect is enhanced with an increase in temperature. At a temperature above 100 ° C the drug is partially decomposed. It is not recommended simultaneous application with iodine.

Form release / dosage:

Solution for topical and topical application 0.05%, 0.2%, 0.5%, 1%, 5%

Packaging:

Solution for local and external use of 25 ml, 50 ml, 70 ml, 100 ml, 200 ml, 500 ml, 1000 ml in bottles of light-protective glass with screw neck, sealed with plastic caps, screw caps or covers with gaskets.25 ml, 50 ml, 70 ml, 100 ml, 200 ml, 500 ml, 1000 ml in high-pressure polyethylene bottles with a polymer packing or with a special cap screw cap or equipped with a spray pump and polyethylene protective cap.

For 3 liters, 5 liters in a glass bottle with ground glass stoppers or screwed plastic covers.

For 3 liters, 5 liters in cans of polyethylene.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years. Do not use after the expiration date stated on the package.

Terms of leave from pharmacies:Without recipe

Registration number:P N000201 / 01

Date of registration:10.09.2008

The owner of the registration certificate:BIOGEN NPC, OAOBIOGEN NPC, OAO Russia

Manufacturer: & nbsp

BIOGEN NPC OJSC Russia

Information update date: & nbsp27.09.2015

Illustrated instructions

Instructions

Chlorhexidine (Chlorhexidine)