Chlorhexidine bigluconate - instructions for use, dose, side effects, contraindications

Pharmacodynamics:Antiseptic. Effective against vegetative forms of Gram-positive and Gram-negative bacteria (Treponema pallidum, Neisseria gonorrhoeae, Chlamydia spp., Ureaplasma spp., Bacteroides fragile); protozoa (Trichomonas vaginalis); viruses Herpes-virus (Herpes simplex type 2), as well as yeast and dermatophytes. Preserves activity (somewhat lowered) in the presence of blood, pus. On bacterial spores acts only at elevated temperature.

Pharmacokinetics:

Virtually not absorbed from the digestive tract. After accidental ingestion, 300 mg of C max is reached after 30 minutes and is 0.206 μg / l. It is excreted mainly by the intestine (90%), less than 1% is excreted by the kidneys.

Indications:

As a therapeutic and prophylactic for various infections.

For topical application: Trichomonas colpitis, cervical erosion, vulvar pruritus, prevention of sexually transmitted infections (chlamydia, ureaplasmosis, trichomoniasis, gonorrhea, syphilis, genital herpes).

Disinfection of purulent wounds, infected burn surfaces; disinfection of the skin (scrapes, cracks), treatment of infections of the skin and mucous membranes in surgery, obstetrics and gynecology, dentistry (rinsing and irrigation - gingivitis, stomatitis, aphthae, periodontitis, alveolitis).

Contraindications:

Hypersensitivity to the components of the drug, dermatitis, allergic reactions.

Carefully:

Children's age, pregnancy, the period of breastfeeding.

Pregnancy and lactation:

Use during pregnancy and breastfeeding is possible if the intended benefit to the mother exceeds the potential risk to the fetus or child.

Before use, consult a physician.

Dosing and Administration:

Outwardly. Locally. It is used in the form of irrigation and applications - 5-10 ml of the drug is applied to the affected surface of the skin or mucous membranes with an exposure of 1-3 min 2-3 times a day (on a tampon or by irrigation). In dentistry is used in the form of rinses 2-3 times a day.

For the prevention of sexually transmitted diseases, the drug is effective if it is used no later than 2 hours after sexual intercourse. Enter a 0.05% solution of chlorhexidine in the vagina (5-10 ml) for 2-3 minutes. Treat the skin of the inner surfaces of the hips, pubic area, genitals. After the procedure, do not urinate for 2 hours.

Complex treatment of urethritis and urethroprostatitis is carried out by injecting into the urethra 2-3 ml 1-2 times a day, the course - 10 days, the procedure is prescribed every other day.

Side effects:

Allergic reactions (skin rash), dry skin, itching, dermatitis, stickiness of the skin of the hands (within 3-5 minutes), photosensitization.

In the treatment of gingivitis - staining the enamel of the teeth, deposition of tartar, a violation of taste.

If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, inform the doctor about it.

Overdose:

Currently, no cases of overdose with external and topical application have been reported; with accidental ingestion is almost not absorbed (should be done by rinsing the stomach using milk, raw egg, gelatin). If necessary, symptomatic therapy is performed.

Interaction:

It is used in a neutral environment. At a pH greater than 8 precipitates. Pharmaceutically incompatible with soap, alkalis and other anionic compounds (colloids, gum arabic, carboxymethyl cellulose). The presence of soap can inactivate chlorhexidine, so before using the drug, soap residues should be thoroughly washed off.

It is not recommended simultaneous use with iodine-containing drugs if they are administered intravaginally.

Compatible with preparations containing a cationic group (benzalkonium chloride, centrimony bromide).

Increases the sensitivity of bacteria to chloramphenicol, kanamycin sulfate, neomycin sulfate, cephalosporins.

Ethanol enhances the effectiveness of the drug.

Special instructions:

In patients with open craniocerebral trauma, spinal cord injuries, perforation of the tympanic membrane, the drug should be avoided on the surface of the brain, the meninges and into the tympanum.

In case of contact with the mucous membranes of the eye, they should be washed quickly and thoroughly with water.

The ingestion of hypochlorite bleaching substances on tissues that previously were in contact with the containing chlorhexidine drugs, can contribute to the appearance of brown spots on them.

The bactericidal effect is enhanced with an increase in temperature. At a temperature above 100 ° C the drug is partially decomposed.

Effect on the ability to drive transp. cf. and fur:Not studied.

Form release / dosage:

Solution for local and external use 0,05%.

Packaging:

To 50, 100 ml in bottles from glass of mark OS with screw mouth of type FV,Cork sealed with plastic caps and screw caps.

To 50, 100 ml in polymeric flasks type FL, ukuporennyh stopper-droppers and caps screwed.

Each bottle, along with instructions for the use of the drug, is placed in a pack of cardboard.

Packaging of vials with an equal number of instructions for the use of a medicinal product in a box of corrugated cardboard or a box of cardboard (for hospitals or production departments of pharmacies) is allowed.

For 0.5 liter, 1 liter, 3 liters, 5 liters in cans of polymer materials or low-density polyethylene (for inpatient or manufacturing departments of pharmacies).

Storage conditions:In the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:

2 years.

Do not use after the time specified on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LP-003537

Date of registration:29.03.2016

Expiration Date:29.03.2021

The owner of the registration certificate:NII OF MEDICINE AND STANDARDIZATION, LLC NII OF MEDICINE AND STANDARDIZATION, LLC Russia

Manufacturer: & nbsp

RFK, CJSC Russia

Information update date: & nbsp18.07.16

Illustrated instructions

Instructions

Chlorhexidine Bigluconate (Chlorhexidine bigluconate)