Chlorhexidine - instructions for use, dose, side effects, contraindications

Effective against gram-positive and gram-negative bacteria, causative agents of sexually transmitted infections - chlamydia, ureaplasmosis, gardnerellez, trichomoniasis, gonorrhea, syphilis, gnital herpes; - Treponema spp., Neisseria gonorrhoeas, Trichomonas spp., Chlamidia spp., Ureaplasma spp.

It acts on acid-fast forms of bacteria, microbial spores, fungi, viruses. Stable, after treatment of the skin (hands, operating field) is stored on it in a certain amount, sufficient for the manifestation of bactericidal effect. Keeps activity (although somewhat reduced) in the presence of blood, pus, various secrets and organic substances.

Pharmacokinetics:

Virtually not absorbed from the digestive tract. After accidentally ingesting 300 mg (338.10 mL) of Cmah is reached after 30 minutes and is 0.206 μg / l. It is produced mainly with a fecal mass (90%), less than 1% is excreted by the kidneys.

Indications:

0,05 % solution: prevention of sexually transmitted infections (chlamydia, ureaplasmosis, trichomoniasis, gonorrhea, syphilis, genital herpes - no later than 2 hours after sexual intercourse); disinfection of the skin (scrapes, cracks).Purulent wounds, infected burns, bacterial and fungal diseases of the skin and mucous membranes in dentistry (rinsings and irrigation - gingivitis, stomatitis, aphthae, paradontitis, alveolitis), surgery, urology, obstetrics-gynecology.

Contraindications:Hypersensitivity, dermatitis, allergic reactions

Carefully:

Children's age, pregnancy, lactation.

Pregnancy and lactation:

The use of chlorhexidine during pregnancy and during breastfeeding is possible after consulting a doctor.

Dosing and Administration:

Outer, local. Chlorhexidine as a preventive and therapeutic agent is used externally and place. 0.05 % the aqueous solution is applied in the form of irrigation and applications - 5-10 ml of the solution is applied to the affected surface of the skin or mucous membranes with an exposure of 1-3 minutes 2-3 times per day (on a tampon or by irrigation).

The treatment of the medical instrument and working surfaces is carried out with a clean sponge, moistened with an antiseptic solution, or by soaking.

For prevention of sexually transmitted diseases chlorhexidine bigluconate It is effective if it is applied no later than 2 hours after sexual intercourse.The contents of the vial with the help of a nozzle to enter the urethra for men (2-3 ml), for women (1-2 ml) and for the vagina (5-10 ml) for 2-3 min. Treat the skin of the inner surfaces of the hips, pubic area, genitals. After the procedure, do not urinate for 2 hours.

Complex treatment of urethritis and urethroprostatitis is carried out by injecting into the urethra 2-3 ml of 0.05% chlorhexidine bigluconate 1-2 times a day, the course is 10 days, the procedures are prescribed every other day.

Rinse solution is usually administered 2-3 times a day.

Side effects:

Allergic reactions (skin rash), dry skin, itching, dermatitis, stickiness of the skin of the hands (within 3-5 minutes), photosensitivity.

In the treatment of gingivitis - dyeing of teeth, deposition of tartar, a violation of taste. Treatment: with accidental ingestion is almost not absorbed (should be done by rinsing the stomach using milk, raw egg, gelatin). If necessary, symptomatic therapy is performed.

If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, inform the doctor about it.

Interaction:

It is used in a neutral environment; at pH 5-8, the difference in activity is small; at a pH of more than 8 - precipitate. The use of hard water slightly reduces bactericidal properties. Pharmaceutically incompatible with soap, alkalis and other anionic compounds (colloids, gum arabic, carboxymethyl cellulose).

Compatible with preparations containing a cationic group (benzalkonium chloride, cetrimonium bromide).

Increases the sensitivity of bacteria to levomitsetinu, kanamycin sulfate, neomycin sulfate, cephalosporins.

Ethanol enhances the effectiveness of the drug.

Special instructions:

In patients with an open craniocerebral trauma, spinal cord injuries, perforation of the tympanic membrane, one should avoid getting to the surface of the brain, the meninges and the drum cavity.

In case of contact with the mucous membranes of the eye, they should be washed quickly and thoroughly with water. The contact of hypochlorite bleaching substances on tissues that previously were in contact with the containing chlorhexidine drugs, can contribute to the appearance of brown spots on them.

The bactericidal effect is enhanced with an increase in temperature. At a temperature above 100 ° C the drug is partially decomposed.

It is not recommended simultaneous application with iodine.

Effect on the ability to drive transp. cf. and fur:

Does not affect.

Form release / dosage:Solution for topical and topical application 0,05%

Packaging:

25 ml, 50 ml, 100 ml in polyethylene terephthalate (PET) bottles with cap or cans with lids, polymeric bottles made of polyethylene with polymeric lids, polymer cans complete with closures or capped with lids, bottles with lids or with lids and dispensers . To 25 ml, 50 ml, 100 ml into orange glass bottles with screw neck, sealed with polyethylene plugs and screw caps. For 100 ml in cans and in bottles of orange glass, corked with aluminum caps. The bottle or jar, together with the instruction for use, is placed in a pack of cardboard. Vials and cans produced without secondary packaging are placed in a group container with enclosed instructions for use in an amount equal to the number of primary packages.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:P N003016 / 01

Date of registration:20.11.2008

The owner of the registration certificate:PHARMACEUTICAL FACTORY of St. Petersburg, JSC PHARMACEUTICAL FACTORY of St. Petersburg, JSC Russia

Manufacturer: & nbsp

Pharmaceutical factory of St. Petersburg, JSC Russia

Information update date: & nbsp27.09.2015

Illustrated instructions

Instructions

Chlorhexidine (Chlorhexidine)