Chlorhexidine Bigluconate (Chlorhexidine bigluconate)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceChlorhexidineChlorhexidine
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    • Dosage form: & nbsp

    solution for local and external use

    Composition:

    0.2% solution:

    Active substance: Chlorhexidine bigluconate 20% - 10 ml Excipient: purified water - up to 1000 ml

    0.5% solution:

    Active substance: Chlorhexidine bigluconate 20% - 25 ml Excipient: purified water - up to 1000 ml

    1% solution:

    Active substance: Chlorhexidine bigluconate 20% - 50 ml Excipient: purified water - up to 1000 ml

    5 % solution:

    Active substance: Chlorhexidine bigluconate 20% - 250 ml Excipient: purified water - up to 1000 ml

    Description:

    Colorless or slightly yellowish tint, a clear or slightly opalescent liquid without a smell.

    Pharmacotherapeutic group:Antiseptic.
    ATX: & nbsp

    D.08.A.C.02   Chlorhexidine

    G.01.A.X   Other antiseptics and antimicrobials for the treatment of gynecological diseases

    Pharmacodynamics:

    Antiseptic and disinfectant. Depending on the concentration used, it shows bacteriostatic and bactericidal effects against Gram-positive and Gram-negative bacteria.

    Effective against causative agents of sexually transmitted infections - gardnerellez, genital herpes; Gram-positive and Gram-negative bacteria - Treponema spp., Neisseria gonorrhoeae, Trichomonas spp., Chlamidia spp., Urcaplasma spp. He acts on acid-fast forms of bacteria, microbial spores, fungi.

    Stable, after treatment of the skin (hands, postoperative field) is stored on it in a certain amount sufficient to manifest a bactericidal effect. Keeps activity (although somewhat reduced) in the presence of blood, pus, various secrets and organic substances.Very rarely causes allergic reactions, skin and tissue irritation, does not have a damaging effect on objects made of glass, plastics and metals.

    Pharmacokinetics:

    Virtually not absorbed from the gastrointestinal tract. After accidental ingestion of 300 mg, the maximum concentration is reached after 30 minutes and is 0.206 μg / L. It is excreted primarily through the intestine (90%), less than 1% is excreted by the kidneys.

    Indications:

    0.2% solution:

    Prevention of infections (no later than 2 hours after sexual intercourse), sexually transmitted (chlamydia, ureaplasmosis, trichomoniasis, gonorrhea, syphilis, genital herpes); disinfection of the skin (scrapes, cracks); purulent wounds, infected burns, bacterial and fungal diseases of the skin and mucous membranes of the urogenital organs, in dentistry (rinsing and irrigation - gingivitis, stomatitis, aphthae, paradontitis, alveolitis).

    0.5% solution:

    Treatment of wounds and burns; treatment of infected scuffs, skin cracks and open mucous membranes. For sterilization of a medical instrument at a temperature of 70 ° C; disinfection of working surfaces of devices (incl.thermometers) and equipment, the heat treatment of which is undesirable.

    1% solution:

    Disinfection of thermometers, working surfaces of medical equipment and devices, whose heat treatment is undesirable, treatment of the surgical field and hands of the surgeon before the operation, disinfection of the skin, treatment of postoperative and burn wounds.

    5% solution:

    Preparation of aqueous, glycerol and alcohol solutions with concentrations from 0.01 to 1 %.

    Contraindications:

    Hypersensitivity, dermatitis.

    Carefully:children's age, pregnancy, lactation.
    Dosing and Administration:

    Locally, externally.

    0.2% solution:

    5-0 ml of the solution is applied to the affected surface of the skin or mucous membranes of the urogenital organs, the oral cavity for 1-3 minutes 2-3 times per day (on a tampon or by irrigation).

    For the prevention of sexually transmitted diseases, the contents of the vial with the aid of a nozzle should be inserted into the urethra for men (2-3 ml), for women (1-2 ml) and in the vagina (5-10 ml) at 2-3 min. After the procedure, it is recommended not to urinate for 2 hours. Treat the skin of the inner surfaces of the hips, pubic area, genitals.

    In case of contact with the mucous membranes of the eye, they should be washed quickly and thoroughly with water.

    0.5% solution:

    Outer in the form of irrigation, rinsing and applications - 5-10 ml of the solution is applied to the affected surface of the skin or mucous membranes with an exposure of 1-3 minutes 2-3 times per day (on a tampon or by irrigation).

    The treatment of the medical instrument and working surfaces is carried out with a clean sponge moistened with the drug solution or by soaking.

    In case of contact with the mucous membranes of the eye, they should be washed quickly and thoroughly with water.

    1% solution:

    Hands of the surgeon before treatment with a solution of antiseptic thoroughly wash with soap and wipe, thoroughly wash the antiseptic hands (20-30 ml). Treatment of the skin of the postoperative wounds is done with a clean swab.

    The treatment of the medical instrument and working surfaces is carried out with a clean sponge moistened with the drug solution or by soaking.

    In case of contact with the mucous membranes of the eye, they should be washed quickly and thoroughly with water.

    5% solution:

    Concentrate is diluted from the calculation of the working concentration of the prepared solution.

    Side effects:

    Allergic reactions, dry and itchy skin, dermatitis, photosensitivity.In the treatment of diseases of the oral cavity - staining the enamel of the teeth, deposition of tartar, a taste disorder, stickiness of the skin of the hands (within 3-5 minutes).

    Interaction:

    Pharmaceutically incompatible with soap, alkalis and other anionic compounds (colloids, gum arabic, carboxymethylcellulose).

    Compatible with preparations containing a cationic group (benzalkonium chloride, cetrimonium bromide). Increases the sensitivity of bacteria to chloramphenicol, kanamycin, neomycin, cephalosporins.

    Ethanol enhances the effectiveness of the drug.

    Special instructions:

    Avoid getting the drug inside the wound in patients with open craniocerebral trauma, spinal cord injuries, perforation of the tympanic membrane.

    In case of contact with the eye mucous membrane, rinse thoroughly and thoroughly with water.

    The ingestion of hypochlorite bleaching substances on tissues that previously were in contact with the containing chlorhexidine drugs, can contribute to the appearance of brown spots on them.

    It is used in a neutral environment; at pH 5-8, the difference in activity is small; at a pH of more than 8 - precipitate. The use of hard water slightly reduces bactericidal properties.

    The bactericidal effect is enhanced with an increase in temperature. At temperatures above 100 ° C the preparation is partially decomposed.

    He simultaneous application with iodine is recommended.

    Does not have a damaging effect on objects made of glass, plastics and metals

    Form release / dosage:0.2%; 0.5%; 1.0% and 5.0% solution for local and external use
    Packaging:

    To 100 ml in a bottle of orange glass or in a can of polyethylene with a lid-dropper.

    Storage conditions:

    In the dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    2 years.

    Do not use after the expiration date stated on the package
    Terms of leave from pharmacies:Without recipe
    Registration number:LSR-000160/09
    Date of registration:16.01.2009
    The owner of the registration certificate:ROSBIO, LLC ROSBIO, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp27.09.2015
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