Chlorhexidine bigluconate - instructions for use, dose, side effects, contraindications

Pharmacodynamics:Antiseptic. Effective against vegetative forms of Gram-positive and Gram-negative bacteria (Treponema pallidum, Neisseria gonorrhoeae, Chlamydia spp., Ureaplasma spp., Bacteroides fragile); protozoa (Trichomonas vaginalis); viruses Herpes-virus (Herpes simplex 2 type), as well as yeast and dermatophytes. Preserves activity (somewhat lowered) in the presence of blood, pus. On bacterial spores acts only at elevated temperature.

Pharmacokinetics:

With local and external application is almost not absorbed.

Indications:

As a therapeutic and prophylactic for various infections. For topical application: Trichomonas colpitis, cervical erosion, vulvar pruritus, prevention of sexually transmitted infections (chlamydia, ureaplasmosis, trichomoniasis, gonorrhea, syphilis, genital herpes). Disinfection of purulent wounds, infected burn surfaces; disinfection of the skin (scrapes, cracks), treatment of skin and mucous membrane infections in surgery, obstetrics and gynecology, urology (urethritis, urethrostroprostatitis), dentistry (rinsing and irrigation - gingivitis, stomatitis, aphthae, periodontitis, alveolitis).

Contraindications:

Hypersensitivity to chlorhexidine and other components of the drug, dermatitis.

Carefully:Childhood, pregnancy, lactation

Pregnancy and lactation:

In pregnancy and during breastfeeding apply only if the intended benefit to the mother exceeds the potential risk to the fetus and the baby.

Dosing and Administration:

Locally. Outwardly.

5-10 ml of the solution is applied to the affected surface of the skin or mucous membranes with an exposure of 1-3 minutes 2-3 times per day (on a tampon or by irrigation).

For the prevention of sexually transmitted diseases, the drug is effective if it is used no later than 2 hours after sexual intercourse. The contents of the vial with the help of a dropper cap should be introduced into the urethra for men (2-3 ml), for women (1-2 ml) and for the vagina (5-10 ml) for 2-3 min. Treat the skin of the inner surfaces of the hips, pubic area, genitals. After the procedure, do not urinate for 2 hours. Complex treatment of urethritis and urethroprostatitis is carried out by injecting into the urethra 2-3 ml of chlorhexidine solution 1-2 times a day, the course - 10 days, the procedure is prescribed every other day.Rinse solution for topical administration is usually administered 2-3 times a day.

Side effects:

Allergic reactions (skin rash), dry skin, pruritus, dermatitis, stickiness of the skin of hands, photosensitization, in the treatment of gingivitis, tooth enamel staining, scaling, taste disturbance.

Overdose:

Currently, no cases of overdose with external and topical application have been reported; with accidental ingestion is almost not absorbed (should be done by rinsing the stomach using milk, raw egg, gelatin). If necessary, symptomatic therapy is performed.

Interaction:

It is used in a neutral environment. At a pH greater than 8 precipitates. The drug is not used in combination with anionic compounds, including soap. The drug is incompatible with carbonates, chlorides, phosphates, borates, sulfates and citrates. Chlorhexidine Bigluconate increases the sensitivity of microorganisms to the action of kanamycin, neomycin, cephalosporins, chloramphenicol. Ethyl alcohol enhances the bactericidal action of the drug.

Special instructions:

In patients with open craniocerebral trauma, spinal cord injuries,Perforation of the tympanic membrane should be avoided on the surface of the brain, the meninges and into the cavity of the inner ear.

In case of contact with the mucous membranes of the eyes, they should be washed quickly and thoroughly with water.

At a temperature above 100 ° C the drug is partially decomposed. It is not recommended simultaneous application with iodine.The ingestion of hypochlorite bleaching substances on tissues that previously were in contact with the containing chlorhexidine drugs, can contribute to the appearance of brown spots on them.

Effect on the ability to drive transp. cf. and fur:

Not studied.

Form release / dosage:

Solution for local and external use 0,05%.

Packaging:

Solution for local and external use 0,05%.

To 25, 50, 80 and 100 ml of the drug in orange glass vials with a screw mouth, sealed with polyethylene plugs and screw caps; or ukuporennyh caps are capping-screwed.

By 25, 50, 80 and 100 ml of the drug in the bottles of imported brown glass, sealed with polyethylene caps with the control of the first autopsy or by pipette caps.

To 25, 50, 80 and 100 ml of the drug into PET flasks, sealed with caps with the control of the first opening or by the capsules-pipettes.

For 80 and 100 ml of the drug in polymer bottles with nozzles-droppers and caps screwed from polymeric materials.

For 80 and 100 ml of the drug in bottles of polyethylene with a polymer lid and a tip.

Each bottle, together with the instructions for use, is placed in a pack of cardboard. The full text of the instructions for use should be applied to the pack.

It is allowed to pack vials without a pack together with an equal number of instructions for use in group packaging (for hospitals).

For 3 and 5 liters of the drug in cans of polyethylene with instructions for use (for hospitals).

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:2 years. Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LP-002708

Date of registration:13.11.2014

The owner of the registration certificate:IVANOVSKAYA Pharmaceutical Factory, OAO IVANOVSKAYA Pharmaceutical Factory, OAO Russia

Manufacturer: & nbsp

IVANOVSKAYA Pharmaceutical Factory, OAO Russia

Information update date: & nbsp26.09.2015

Illustrated instructions

Instructions

Chlorhexidine Bigluconate (Chlorhexidine bigluconate)