Sodium chloride - instructions for use, dose, side effects, contraindications

Plasma-substituting agent. Has a detoxifying and rehydrating effect. Replenishes sodium deficiency in various pathological conditions of the body.0.9% solution of sodium chloride is isotonic with human plasma and is therefore rapidly eliminated from the vascular bed, only temporarily increasing the volume of circulating blood (effectiveness with blood loss and shock is insufficient).

Pharmacokinetics:

Concentration Na+ - 142 mmol / L (plasma) and 145 mmol / L (interstitial fluid), the chloride concentration is 101 mmol / L (interstitial fluid). It is excreted by the kidneys unchanged.

Indications:

Large losses of extracellular fluid or insufficient intake (toxic dyspepsia, cholera, diarrhea, "indomitable" vomiting, extensive burns with severe exudation, etc.), hypochloremia and hyponatremia with dehydration, intestinal obstruction, intoxication; washing of wounds, eyes, nasal mucosa; moistening of the dressing material.

Contraindications:

Hypernatremia, acidosis, hyperchloremia, hypokalemia, extracellular hyperhydration; circulatory disorders that threaten edema of the brain and lungs, cerebral edema, pulmonary edema, acute left ventricular failure, concomitant administration of glucocorticosteroids in large doses.

Carefully:

Decompensated chronic cardiac insufficiency, chronic renal failure (oligoanuria).

Pregnancy and lactation:

No information.

Dosing and Administration:

Isotonic solution (0.9%) of sodium chloride for infusions is administered intravenously (usually drip); subcutaneously; rectally (in enemas up to 3 liters / day).

Before administration, the solution is heated to 36-38 ° C. The dose is determined depending on the loss of body fluids, sodium ions and chlorine - an average of 1 liter / day. With large losses of fluid and severe intoxication, administration up to 3 liters / day is possible. The rate of administration is 540 ml / h (180 cap / min); if necessary, the rate of administration is increased.

Children with a marked decrease in blood pressure on the background of dehydration (before determining the laboratory parameters) are administered 20-30 ml / kg. In the future, the dosage regimen is adjusted depending on the laboratory parameters.

With prolonged administration of large doses of 0.9% solution of sodium chloride, it is necessary to monitor electrolytes in plasma and urine.

0.9% solution of sodium chloride is used for washing wounds, eyes, mucous membrane of the nasal cavity, moistening the dressing.

Side effects:

The introduction of large volumes of isotonic sodium chloride solution can lead to chloride acidosis and hyperhydration, as well as to hypokalemia.

Interaction:

Compatible with colloid hemodynamic blood substitutes (mutual enhancement of the effect).

When mixed with other drugs, you need to visually check for compatibility.

Special instructions:

With long-term administration of large doses of isotonic sodium chloride solution, it is necessary to monitor the acid-base state and electrolytes in blood plasma and urine.

With significant dehydration with the impossibility of intravenous administration is administered subcutaneously or rectally.

Form release / dosage:

Solution for infusion 0.9%.

Packaging:

By 250, 1000, 2000 ml into PVC containers for single-use infusion solutions. Containers are packed in a bag of polyethylene or polyethylene polyamide films.

For hospitals: 250 ml of 25 containers; 1000 ml of 6, 8 or 10 containers; 2000 ml of 4, 5 or 6 containers together with an equal number of instructions for use are placed in a box of cardboard.

Storage conditions:

In a dry place inaccessible to children, at a temperature of 0 to 25 ° C.Freezing the drug, provided that the integrity of the container is not a contraindication to the use of the drug.

Shelf life:2 years. Do not use after expiry date.

Terms of leave from pharmacies:For hospitals

Registration number:LSR-004212/08

Date of registration:30.05.2008 / 17.11.2009

Expiration Date:Unlimited

The owner of the registration certificate:RESERV-M, LLC RESERV-M, LLC Russia

Manufacturer: & nbsp

RESERV-M, LLC Russia

Information update date: & nbsp15.06.2018

Illustrated instructions

Instructions

Sodium chloride (Sodium chloride)