Sodium chloride - instructions for use, dose, side effects, contraindications

Plasma-substituting agent. Has a detoxifying and rehydrating effect. Replenishes sodium deficiency Na+ at various pathological conditions of an organism. 0.9% solution of sodium chloride is isotonic with human plasma and is therefore rapidly eliminated from the vascular bed, only temporarily increasing the volume of circulating blood (effectiveness with blood loss and shock is insufficient).

Pharmacokinetics:

Concentration Na+ - 142 mm.ol / l (plasma) and 145 mmol / l (interstitial fluid), chloride concentration -101 mmol / l (interstitial fluid). It is excreted by the kidneys unchanged.

Indications:

Large losses of extracellular fluid or insufficient intake of it (toxic dyspepsia, cholera, diarrhea, "indomitable" vomiting, extensive burns with severe exudation, etc.), hypochloraemia and hyponatremia with dehydration.

Contraindications:

Hypernatremia, acidosis, hyperchloremia, hypokalemia, extracellular hyperhydration; circulatory disorders; threatening edema of the brain and lungs, cerebral edema, pulmonary edema, acute left ventricular failure, concomitant administration of glucocorticosteroids in large doses.

Carefully:Decompensated chronic heart failure, chronic renal failure (oliguria, anuria).

Pregnancy and lactation:It is used in pregnancy and lactation.

Dosing and Administration:

Isotonic solution (0.9%) of sodium chloride for infusions is administered intravenously, usually drip.

Before administration, the solution is heated to 36-38 ° C. The dose is determined, depending on the loss of body fluids, sodium and chloride ions and an average of 1 liter / day. With large losses of fluid and severe intoxication, it is possible to administer up to 3 times daily. The rate of administration is 540 ml / h (180 cap / min); if necessary, the rate of administration is increased.

Children with a marked decrease in blood pressure in the background Dehydration (before the determination of laboratory parameters) is administered 20-30 ml / kg. In the future, the dosage regimen is adjusted depending on the laboratory parameters (control of the acid-base state and the level of electrolytes in plasma and urine). The total daily dose is up to 6% of body weight.

With prolonged administration of large doses of 0.9% solution of sodium chloride, it is necessary to monitor the electrolytes in plasma and urine.

Side effects:While observing the recommended dosage regimens, side effects were not recorded.

Overdose:

Symptoms: When using large volumes of isotonic solution, edema, hypernatremia, hyperchloremia, hypokalemia may occur.

Treatment: It is recommended the introduction of hypertonic solution of NaCl, strong diuretics (with acute cardiac insufficiency and pulmonary edema), correction of electrolyte balance.

Interaction:

Compatible with colloid hemodynamic blood substitutes (mutual enhancement of the effect). When mixed with other drugs, you need to visually check for compatibility.

Special instructions:

With long-term administration of large doses of isotonic sodium chloride solution, it is necessary to monitor the acid-base state and electrolytes in blood plasma and urine.

With prolonged administration of large amounts of sodium chloride solution 0,9%, it is desirable to monitor the content of electrolytes in blood plasma.

Caution should be given to large volumes of solution to patients with renal insufficiency.

Freezing the drug under the condition of integrity of the tightness is not a contraindication to its use.

Effect on the ability to drive transp. cf. and fur:Does not affect.

Form release / dosage:

Solution for infusion 0.9%.

Packaging:

By 100, 250, 500 or 1000 ml into polymeric containers for infusion solutions.

Each polymer container, along with instructions for medical use, is placed in a plastic bag.

For hospitals: Polymeric containers, together with instructions for medical use in an amount corresponding to the number of containers, are placed in boxes of cardboard corrugated.

Storage conditions:

At a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:2 years.

Terms of leave from pharmacies:On prescription

Registration number:P N013148 / 01-2001

Date of registration:20.05.2009 / 06.10.2011

Expiration Date:Unlimited

The owner of the registration certificate:FARMLEND JV, LLC FARMLEND JV, LLC Republic of Belarus

Manufacturer: & nbsp

FARMLEND JV, LLC Republic of Belarus

Information update date: & nbsp15.06.2018

Illustrated instructions

Instructions

Sodium chloride (Sodium chloride)