Sodium chloride - instructions for use, dose, side effects, contraindications

Plasma-substituting agent. Has a detoxifying and rehydrating effect. Replenishes the deficiency of sodium ions in various pathological conditions.0.9% solution of sodium chloride is isotonic with human plasma and is therefore rapidly eliminated from the vascular bed, only temporarily increasing the volume of circulating blood (effectiveness with blood loss and shock is insufficient).

Pharmacokinetics:

The concentration of sodium ions is 142 mmol / l (plasma) and 145 mmol / l (interstitial fluid), the chloride concentration is 101 mmol / l (interstitial fluid). It is excreted by the kidneys.

Indications:

Sodium chloride solution for infusion 0.9% is used for large losses of extracellular fluid or insufficient intake (toxic dyspepsia, cholera, diarrhea, "indomitable" vomiting, extensive burns with severe exudation, etc.), hypochloremia and hyponatremia with dehydration, intestinal obstruction , intoxication, for regional perfusion together with heparin, antitumor and other drugs, for dissolution and dilution of drugs.

Contraindications:

Hypernatremia, acidosis, hyperchloremia, hypokalemia, extracellular hyperhydration, circulatory disorders threatening edema of the brain and lungs, cerebral edema, pulmonary edema, acute left ventricular failure, concomitant administration of glucocorticosteroids in large doses.

Carefully:

Decompensated chronic heart failure, chronic renal failure (oligo-, anuria).

Pregnancy and lactation:

No information.

Dosing and Administration:

Sodium chloride solution for infusion 0.9% is administered intravenously (usually drip).

Before administration, the solution is heated to 36-38 ° C. The dose is determined depending on the loss of body fluids, sodium and chloride ions and on average is 1000 ml / day. With large fluid loss and severe intoxication, administration of up to 3000 ml / day is possible. The rate of administration is 540 ml / h (180 cap / min); if necessary, the rate of administration is increased.

Children with a marked decrease in blood pressure on the background of dehydration (before determining the laboratory parameters) are administered 20-30 ml / kg.

Later, the dosage regimen is adjusted depending on laboratory parameters (electrolytes in blood plasma and urine, acid-base blood state).

Side effects:

The introduction of large volumes of the drug can lead to chloride acidosis and hyperhydration, as well as to hypokalemia.

Interaction:

Compatible with colloid hemodynamic blood substitutes (mutual enhancement of the effect: increase in the volume of circulating blood).

When mixed with other drugs, it is necessary to visually check compatibility (nevertheless, invisible and therapeutic incompatibility is possible).

Special instructions:With prolonged administration of large doses of the drug, it is necessary to monitor the acid-base state and electrolytes in blood plasma and urine.

Effect on the ability to drive transp. cf. and fur:Does not affect.

Form release / dosage:

Solution for infusion 0.9%.

Packaging:

In bottles of 200 ml and 400 ml. 1 bottle with instructions for use in a pack of cardboard.

For 15 or 28 bottles with a capacity of 250 ml or 15 bottles with a capacity of 450 ml in a box of corrugated cardboard with gaskets and grids (sockets) without pre-stacking. In the box, insert instructions for use, in an amount equal to the number of bottles (for hospitals).

Storage conditions:

Store at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Freezing the drug under the condition of the integrity of the tightness of the bottle is not a contraindication to bringing the drug.

Non-wetting of the inner surface of the bottle is not a contraindication to the use of the drug.

In the event of a change in the color of the preparation or the appearance of a suspension, the solution is not suitable for use.

Shelf life:1 year. Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:P N001083 / 01

Date of registration:21.01.2008 / 04.04.2014

Expiration Date:Unlimited

The owner of the registration certificate:MICROGEN FGUP Scientific and Production Association MICROGEN FGUP Scientific and Production Association Russia

Manufacturer: & nbsp

MICROGEN FGUP NGO Russia

Information update date: & nbsp15.06.2018

Illustrated instructions

Instructions

Sodium chloride (Sodium chloride)