Sodium chloride - instructions for use, dose, side effects, contraindications

Plasma-substituting agent. Has a detoxifying and rehydrating effect. Replenishes sodium deficiency in various pathological conditions of the body.0.9% solution of sodium chloride is isotonic with human plasma and is therefore rapidly eliminated from the vascular bed, only temporarily increasing the volume of circulating blood (effectiveness with blood loss and shock is insufficient).

Pharmacokinetics:

Concentration Na+ - 142 mmol / l (plasma) and 145 mmol / L (interstitial fluid), chloride concentration - 101 mmol / l (interstitial fluid).

It is excreted by the kidneys unchanged.

Indications:

Large losses of extracellular fluid or insufficient intake (toxic dyspepsia, cholera, diarrhea, "indomitable" vomiting, extensive burns with severe exudation, etc.), hypochloremia and hyponatremia with dehydration, intestinal obstruction, intoxication; washing of wounds, eyes, nasal mucosa; dissolution and dilution of medicinal products and moistening of the dressing material.

Contraindications:

Hypernatremia, acidosis, hyperchloremia, hypokalemia, extracellular hyperhydration; circulatory disorders that threaten edema of the brain and lungs, cerebral edema, pulmonary edema, acute left ventricular failure, concomitant administration of glucocorticosteroids in large doses.

Carefully:

Decompensated chronic cardiac insufficiency, chronic renal failure (oligo-, anuria).

Pregnancy and lactation:

No information.

Dosing and Administration:

Isotonic solution (0.9%) of sodium chloride for infusions is administered intravenously (usually drip); subcutaneously; rectally (in enemas up to 3 liters / day).

Before administration, the solution is heated to 36-38 ° C. The dose is determined depending on the loss of body fluids, sodium ions and chlorine - an average of 1 liter / day. With large losses of fluid and severe intoxication, administration up to 3 liters / day is possible. The rate of administration is 540 ml / h (180 cap / min); if necessary, the rate of administration is increased.

Children with a marked decrease in blood pressure on the background of dehydration (before determining the laboratory parameters) are administered 20-30 ml / kg. In the future, the dosage regimen is adjusted depending on the laboratory parameters.

With prolonged administration of large doses of 0.9% solution of sodium chloride, it is necessary to monitor electrolytes in plasma and urine.

0.9% solution of sodium chloride is used for washing wounds, eyes, mucous membrane of the nasal cavity, moistening the dressing.

Side effects:

The introduction of large volumes of isotonic sodium chloride solution can lead to chloride acidosis and hyperhydration, as well as to hypokalemia.

Interaction:

Compatible with colloid hemodynamic blood substitutes (mutual enhancement of the effect).

When mixed with other drugs, you need to visually check for compatibility.

Special instructions:

With long-term administration of large doses of isotonic sodium chloride solution, it is necessary to monitor the acid-base state and electrolytes in blood plasma and urine.

With significant dehydration with the impossibility of intravenous administration is administered subcutaneously or rectally.

Form release / dosage:

Solution for infusion 0.9%.

Packaging:By 100, 200, 250, 400 and 500 ml into polymeric containers of multilayer film based on polypropylene. Containers of 80 pieces with a capacity of 100 ml, containers of 20 pieces with a capacity of 400 and 500 ml and containers of 40 pieces with a capacity of 200 and 250 ml are placed in boxes of cardboard corrugated. In the container box, 80, 20 and 40 instructions for use, respectively. Polymer containers of multilayer film, with a capacity of 100, 200 and 250 ml, in individual packaging with instructions for use.

Storage conditions:

Store in a dry place, protected from light, out of reach of children, at a temperature not exceeding + 25 ° С.

Freezing the drug (provided that the packaging is kept sealed) is not a contraindication to its use.

Shelf life:

2 years. Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:For hospitals

Registration number:LSR-001839/08

Date of registration:17.03.2008 / 26.05.2009

Expiration Date:Unlimited

The owner of the registration certificate:SAKHAMEDPROM, SUE SAKHAMEDPROM, SUE Russia

Manufacturer: & nbsp

SAHAMEDPROM GUP Russia

Information update date: & nbsp16.06.2018

Illustrated instructions

Instructions

Sodium chloride (Sodium chloride)