Sodium chloride - instructions for use, dose, side effects, contraindications

Pharmacodynamics:Plasma-substituting agent. Has a detoxifying and rehydrating effect. Replenishes sodium deficiency in various pathological conditions of the body.0.9% solution of sodium chloride is isotonic with human plasma and is therefore rapidly eliminated from the vascular bed, only temporarily increasing the volume of circulating blood (effectiveness with blood loss and shock is insufficient).

Pharmacokinetics:

Concentration Na+ - 142 mmol / L (plasma) and 145 mmol / L (interstitial fluid), chloride concentration -101 mmol / L (interstitial fluid).

It is excreted by the kidneys unchanged.

Indications:

Large losses of extracellular fluid or insufficient intake (toxic dyspepsia, cholera, diarrhea, "indomitable" vomiting, extensive burns with severe exudation, etc.), hypochloremia and hyponatremia with dehydration, intestinal obstruction, intoxication; washing of wounds, eyes, nasal mucosa; dissolution and dilution of medicinal products and moistening of the dressing material.

Contraindications:

Hypernatremia, acidosis, hyperchloremia, hypokalemia, extracellular hyperhydration; circulatory disorders that threaten edema of the brain and lungs, cerebral edema, pulmonary edema, acute left ventricular failure, concomitant administration of glucocorticosteroids in large doses.

Carefully:Decompensated chronic heart insufficiency, chronic renal failure (oligo, anuria).

Pregnancy and lactation:No information.

Dosing and Administration:

Isotonic solution (0.9%) of sodium chloride for infusions is administered intravenously (usually drip); subcutaneously; rectally (in enemas up to 3 liters / day).

Before administration, the solution is heated to 36-38 ° C. The dose is determined depending on the loss of body fluids, sodium ions and chlorine - an average of 1 liter / day. With large losses of fluid and severe intoxication, it is possible to administer up to 3 times daily. The rate of administration is 540 ml / h (180 cap / min); if necessary, the rate of administration is increased.

Children with a marked decrease in blood pressure on the background of dehydration (before determining the laboratory parameters) are administered 20-30 ml / kg. In the future, the dosage regimen is adjusted depending on the laboratory parameters.

With prolonged administration of large doses of 0.9%) sodium chloride solution, it is necessary to monitor the electrolytes in plasma and urine.

0,9% solution of sodium chloride is used to wash wounds, eyes, mucous membrane of the nasal cavity, moistening the dressing.

Side effects:

The introduction of large volumes of isotonic sodium chloride solution can lead to chloride acidosis and hyperhydration, as well as to hypokalemia.

Interaction:

Compatible with colloid hemodynamic blood substitutes (mutual enhancement of the effect).

When mixed with other drugs, you need to visually check for compatibility.

Special instructions:

With long-term administration of large doses of isotonic sodium chloride solution, it is necessary to monitor the acid-base state and electrolytes in blood plasma and urine.

With significant dehydration with the impossibility of intravenous administration is administered subcutaneously or rectally.

Form release / dosage:

Solution for infusion 0.9%.

Packaging:

For 200 and 400 ml in glass bottles for blood, transfusion and infusion preparations with a capacity of 250 ml, 450 ml respectively, corked with rubber stoppers, crimped with aluminum caps.

Each bottle, together with instructions for use, is placed in a pack of cardboard. Bundles are placed in cardboard boxes with partitions or lattices of cardboard corrugated.

For hospitals: 40 bottles of 200 ml,24 bottles of 400 ml along with 10-15 instructions for use are placed in cardboard boxes.

Storage conditions:

In a dry place inaccessible to children, at a temperature not exceeding 25 ° C. Freezing the drug under the condition of integrity of the tightness is not a contraindication to its use.

Non-wetting of the inner surface of bottles is not a contraindication to the use of the drug.

Shelf life:

2 years. Do not use after expiry date.

Terms of leave from pharmacies:On prescription

Registration number:П N014795 / 01

Date of registration:29.07.2008 / 22.04.2010

Expiration Date:Unlimited

The owner of the registration certificate:NESVIZH FACTORY OF MEDICAL PREPARATIONS, RUP NESVIZH FACTORY OF MEDICAL PREPARATIONS, RUP Republic of Belarus

Manufacturer: & nbsp

NESVIZH FACTORY OF MEDICAL PREPARATIONS, RUP Republic of Belarus

Information update date: & nbsp15.06.2018

Illustrated instructions

Instructions

Sodium chloride (Sodium chloride)