Sodium chloride - instructions for use, dose, side effects, contraindications

Plasma-substituting agent. Has a detoxifying and rehydrating effect. Replenishes the deficiency of sodium and chlorine ions and maintains the corresponding osmotic pressure of blood plasma and extracellular fluid at various pathological conditions. 0.9% solution of sodium chloride is isotonic with human plasma and therefore, it is rapidly excreted from the vascular bed, only temporarily increasing the volume of circulating blood (BCC) (effectiveness with blood loss and shock is insufficient).

Pharmacokinetics:

Concentration of ions Na⁺ - 142 mmol / L- (plasma) and 145 mmol / L (interstitial fluid), the chloride concentration is 101 mmol / L (interstitial fluid). Displayed kidneys.

Indications:

Dehydration of various genesis: large losses of extracellular fluid or insufficient intake (toxic dyspepsia, cholera, diarrhea, "indomitable" vomiting, extensive burns with severe exudation); hypochloraemia and hyponatremia with dehydration (non-dilution), hypovolemic shock (auxiliary therapy), intestinal obstruction, intoxication, maintenance of plasma volume before and after operations.

Contraindications:

Hypernatremia / acidosis, hyperchloremia, hypokalemia, extracellular hyperhydration; circulatory disorders that threaten edema of the brain and lungs; edema of the brain, pulmonary edema, acute left ventricular failure, concomitant administration of glucocorticosteroids in large doses.

Carefully:

Decompensated chronic heart failure, chronic renal failure insufficiency (oligo-, anuria).

Pregnancy and lactation:

A 0.9% solution of sodium chloride can be used according to indications during pregnancy and during lactation.

Dosing and Administration:

Intravenously (intravenously) is drip. Prior to the introduction, it is recommended to heat the solution to 36-38 ° with.

In adults: the dose is determined depending on the loss of body fluids, Na⁺ and Cl^- and on the average makes 1 l / day. With large losses of fluid and severe intoxication, administration up to 3 l / day is possible. The rate of administration is 540 ml / h; if necessary, the rate of administration is increased.

Children with a marked decrease in blood pressure on the background of dehydration (before determining the laboratory parameters) are administered 20-30 ml / kg. In the future, the dosage is adjusted depending on the physiological need for a liquid and the content of electrolytes in plasma.

Side effects:

When using a 0.9% solution of sodium chloride in doses exceeding therapeutic, can develop acidosis, hyperhydration, hypokalemia.

Overdose:

Symptoms: Introduction 0.9 % solution of sodium chloride in doses exceeding therapeutic, can lead to hyperchloremic acidosis and hyperhydration, as well as to hypokalemia, which is manifested by muscle weakness and instability of blood pressure. If a 0.9% solution of sodium chloride is used as a base solution for the dilution of transport of other drugs, symptoms with excessive administration are most often associated with the properties of drugs added to the solution.

Treatment: should stop the introduction of 0.9% solution of sodium chloride; symptomatic therapy.

Interaction:

When mixed with other drugs, you need to visually check for compatibility.

Special instructions:Use only intact vials. With prolonged administration of large volumes, it is recommended to monitor the acid-base state and electrolytes of blood plasma.

Effect on the ability to drive transp. cf. and fur:There is no data indicating a negative effect of the sodium chloride solution on the ability to drive vehicles and engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Form release / dosage:

Solution for infusions, 0,9%.

Packaging:

100 ml in bottles or bottles of glass with a capacity of 100 ml, hermetically sealed with rubber stoppers, crimped with aluminum or combined caps (aluminum with safety plastic caps).

Each label (bottle) is labeled with a label or a self-adhesive label, a RFID sensor or RFID sensor.

1 bottle (bottle), together with the instruction for use, is placed in a pack of cardboard.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C. Do not freeze. Keep out of the reach of children.

Shelf life:

2 years. Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:LP-000629

Date of registration:23.09.2011

Expiration Date:23.09.2016

The owner of the registration certificate:ABOLMED, LLC ABOLMED, LLC Russia

Manufacturer: & nbsp

ABOLMED, LLC Russia

Information update date: & nbsp15.06.2018

Illustrated instructions

Instructions

Sodium chloride (Sodium chloride)